Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype by Alan L. Ho (153035)

“…MAPK activation occurs via somatic mutations in the heterotrimeric G protein subunits <em>GNAQ</em> and <em>GNA11</em> for over 70% of tumors and less frequently via V600E <em>BRAF</em> mutations. In this report, we describe the impact of dual pathway inhibition upon uveal melanoma cell lines with the MEK inhibitor selumetinib (AZD6244/ARRY-142886) and the ATP-competitive mTOR kinase inhibitor AZD8055. …”

An Exploration of Smoking Patterns Among People with Serious Mental Illness Attending an Outpatient Clinic in Qatar by Zolezzi, Monica

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Barriers and Motivators of Appropriate Antibiotic Prescription at PHCC in Qatar: Perspective of Physicians and Pharmacists by Sharaf, Nahla

“…Antimicrobial resistance (AMR) is a serious public health problem of global concern. …”
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Barriers and motivators of appropriate antibiotic prescription at PHCC in Qatar: perspective of physicians and pharmacists by Sharaf, Nahla

“…Antimicrobial resistance (AMR) is a serious public health problem of global concern. …”
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Image 2_Bacillus Spizizenii FMH45-based biofertilizer enhances growth and halotolerance of cherry tomato plants under hydroponic cultivation systems.tif by Fatma Masmoudi (16819554)

“…Furthermore, HB45-treatment enhanced the plant oxidative stress response as evidenced by stable catalase activity, an approximately 50% reduction in lipid peroxidation markers such as malondialdehyde (MDA), and a 35% decrease in reactive oxygen species (ROS), including hydrogen peroxide (H₂O₂). …”

RyhB binding at Site I and Site II blocks ribosome binding to the <i>msrB</i> translation initiation region. by Julia Bos (411731)

“…<p>(A) An autoradiogram of a toeprint analysis is shown (for details, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063647#s2" target="_blank">Materials and Methods</a>, and Results). …”

Data_Sheet_1_Network analysis of live pig movements in North Macedonia: Pathways for disease spread.pdf by Kathleen C. O'Hara (11769671)

“…In 2019, the network demonstrated a marked decrease in betweenness and increase in communities. …”

Table_1_AHLs Regulate Biofilm Formation and Swimming Motility of Hafnia alvei H4.DOCX by Yao lei Zhu (6855239)

“…Furthermore, ΔluxI also exhibited significant (P < 0.05) decrease in the expression of biofilm- and swimming motility-related genes, flgA, motA and cheA, consistent with the results observed for biofilm formation and swimming motility. …”

Regulation of the Inevitable Water-Responsivity of Silk Fibroin Biopolymer by Polar Amino Acid Activation by Woojin Choi (610810)

“…Furthermore, the water dynamics study suggested that active amino acid stabilizes crystallization-triggering water molecules. As a proof-of-concept, we verified that a 30% increase in the activity of serine resulted in a 50% decrease in the crystallization rate. …”

Animals in each vaccine group demonstrate similar plasma viral loads, CD4⁺ T cell counts, and ART responsiveness. by Hillary Claire Tunggal (10987656)

“…The dotted line indicates 50% of baseline CD4⁺ T cells. CD4 T cell counts were obtained using a Beckman Coulter^® AC*T^™ 5diff hematology analyzer. …”

Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling-1 by Eric R Londin (83702)

“…Induction of results in a 50% increase in Sip1 expression, conversely, inhibition of results in a 70% reduction of Sip1 expression. …”

Calpain mediated the cleavage of calcineurin in PAN-treated podocytes. by Fangrui Ding (659863)

“…(C, D) The expression of cleaved 45-kDa calcineurin was dependent on the increased concentration of PAN (25, 50, 75, 100, and 125 μg/ml) in podocytes and was associated with a dose-dependent decrease in 60-kDa calcineurin. …”

Image_1_Verification of autoclaving-cooling treatment to increase the resistant starch contents in food starches based on meta-analysis result.jpg by Didah Nur Faridah (3844126)

“…Verification using corn flour and corn starch showed a significant increase in RS contents from 15.84 to 27.78% and from 15.27 to 32.53%, respectively, and a significant decrease in starch digestibility from 67.02 to 35.74% and from 76.15 to 28.09%, respectively. …”

Doxorubicin-Mediated Bone Loss in Breast Cancer Bone Metastases Is Driven by an Interplay between Oxidative Stress and Induction of TGFβ by Tapasi Rana (339809)

“…Doxorubicin, which is a known inducer of oxidative stress, decreased osteoblast survival and differentiation, which was rescued by N-acetyl cysteine (NAC). …”

Data_Sheet_1_Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway.DOCX by Abhirup Shaw (11545129)

“…Gene expression data indicated upregulation of the NFκB pathway upon irisin treatment, which was validated by an increase of p50 and decrease of IκBα protein level, respectively. …”

Influence of acute slice preparation protocols on receptor subcellular localization and basal interneuron activity in the CA1 area. by Xavier Rezai (5656768)

“…Application of the delta opioid receptor agonist deltorphin II (500 nM) induces a comparable and washable decrease in DOR-eGFP KI and wild type but has no effect in DOR KO mice.…”

Image_1_Isolation and characterization of Priestia megaterium KD7 for the biological control of pear fire blight.TIF by Zeling Cui (14763859)

“…Furthermore, the active compounds of strain KD7 were separated by thin layer chromatography (TLC) and the amino acids were detected by the presence of a spot with retention factor (Rf) of 0.71. Next, three lipopeptides were identified with high-resolution mass spectrometry (HRMS), including C13-surfactin [M+H]⁺ at m/z 1008.14, C15-surfactin [M+H]⁺ at m/z 1036.50, and C14-iturin A [M+H]⁺ at m/z 1043.17. …”

Image 3_Bacillus Spizizenii FMH45-based biofertilizer enhances growth and halotolerance of cherry tomato plants under hydroponic cultivation systems.tif by Fatma Masmoudi (16819554)

“…Furthermore, HB45-treatment enhanced the plant oxidative stress response as evidenced by stable catalase activity, an approximately 50% reduction in lipid peroxidation markers such as malondialdehyde (MDA), and a 35% decrease in reactive oxygen species (ROS), including hydrogen peroxide (H₂O₂). …”

Disruption of preformed <i>Salmonella</i> biofilms by JG-1 and M4. by Jenna L. Sandala (5989862)

“…Corresponding EC₅₀ values for biofilm disruption were calculated for JG-1 [67.8μM (95% CI, 43.0–124.6 μM)] and M4 [65.4 (95% CI, 46.5–97.6 μM)] as described in <b>C</b>. …”

Supplementary Material for: Plasma Mucin-1 (CA15-3) Levels in Autosomal Dominant Tubulointerstitial Kidney Disease due to <b><i>MUC1</i></b> Mutations by Vylet’al P. (10932213)

“…<b><i>Introduction:</i></b> Patients with ADTKD-<i>MUC1</i> have one allele producing normal mucin-1 (MUC1) and one allele producing mutant MUC1, which remains intracellular. We hypothesized that ADTKD-<i>MUC1</i> patients, who have only 1 secretory-competent wild-type <i>MUC1</i> allele, should exhibit decreased plasma mucin-1 (MUC1) levels. …”