An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

DataSheet_1_Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…</p>Results<p>In cervical cancer celllines C33A and HeLa, the stapled peptide strongly downregulated PD-L1 to < 50% of baseline level at 0.1 μM. …”

Role of NH₃ in the Electron-Induced Reactions of Adsorbed and Solid Cisplatin by Jonas Warneke (1555696)

“…Finally, FEBID experiments using cisplatin adsorbed from the gas phase onto a surface produced amorphous deposits. In contrast to the decomposed cisplatin particles, these deposits had a chlorine content of about 50 at. %. …”

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells by Antoine Nougairede (5649739)

“…<div><p>Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. …”

Video_3_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Table_3_Covid-19 Has Turned Home Advantage Into Home Disadvantage in the German Soccer Bundesliga.DOCX by Markus Tilp (9610370)

“…The distribution of fouls showed a significant difference to equal distribution in GWA [home: 2,595 (48.56%); away: 2,749 (51.44%)] but not in GWOA [home: 1,067 (50.54%); away: 1,044 (49.46%)]. …”

Role of NH₃ in the Electron-Induced Reactions of Adsorbed and Solid Cisplatin by Jonas Warneke (1555696)

“…Finally, FEBID experiments using cisplatin adsorbed from the gas phase onto a surface produced amorphous deposits. In contrast to the decomposed cisplatin particles, these deposits had a chlorine content of about 50 at. %. …”

Video_4_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Table_2_Covid-19 Has Turned Home Advantage Into Home Disadvantage in the German Soccer Bundesliga.DOCX by Markus Tilp (9610370)

“…The distribution of fouls showed a significant difference to equal distribution in GWA [home: 2,595 (48.56%); away: 2,749 (51.44%)] but not in GWOA [home: 1,067 (50.54%); away: 1,044 (49.46%)]. …”

DataSheet1_Acute and Long-Term Treatment With Dapagliflozin and Association With Serum Soluble Urokinase Plasminogen Activator Receptor.DOCX by Viktor Rotbain Curovic (9182235)

“…<p>Background: Elevated soluble urokinase plasminogen activator receptor (suPAR) is highly associated with increased risk of diabetic complications. Dapagliflozin is a drug inhibiting the sodium-glucose co-transporter 2 in the kidney to decrease blood glucose, while also decreasing risk of kidney disease, heart failure, and death. …”

Video_2_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Lab 2:Biol2050 Woodlot Data Set 4 by Katrin Chapkis (797943)

“…This process was performed a total of 10 times.</p>…”

Burst stimulation. by Damian M. Herz (16007088)

“…<b>(C)</b> Same as A for peak force aligned data. <b>(D)</b> There were no significant effects of stimulation on change in force (positive values for increase in force, negative values for decrease in force) on the next trial when aligning data to the feedback cues. …”

Table_1_Covid-19 Has Turned Home Advantage Into Home Disadvantage in the German Soccer Bundesliga.DOCX by Markus Tilp (9610370)

“…The distribution of fouls showed a significant difference to equal distribution in GWA [home: 2,595 (48.56%); away: 2,749 (51.44%)] but not in GWOA [home: 1,067 (50.54%); away: 1,044 (49.46%)]. …”

Overexpression of necdin ameliorates the motor axon outgrowth phenotype in <i>smn</i> morphant zebrafish. by Penelope J. Boyd (3936893)

“…Note the presence of the axonal outgrowth phenotype associated with <i>smn</i> knockdown (arrow heads) is reduced in the Ndn expressing animals. Scale bars = 50 μM. (D) Bar chart (mean & s.e.m.) showing a significant increase in the number of normal MNs, and a concomitant significant decrease in the number of severely affected MNs, in co-injected <i>smn</i> MO and Ndn mRNA embryos compared to single <i>smn</i> MO injected embryos at 30 hpf. …”

Histology of wild-type and <i>oltNH</i> hair follicles during hair follicle morphogenesis and the beginning of the first cycle. by Fabian Runkel (157823)

“…Bar  = 100 µm in images A to X, and 50 µm in images G* to L* and S* to X*.…”

Role of NH₃ in the Electron-Induced Reactions of Adsorbed and Solid Cisplatin by Jonas Warneke (1555696)

“…Finally, FEBID experiments using cisplatin adsorbed from the gas phase onto a surface produced amorphous deposits. In contrast to the decomposed cisplatin particles, these deposits had a chlorine content of about 50 at. %. …”

Data_Sheet_1_Effect of Engineered Nickel Oxide Nanoparticle on Reactive Oxygen Species–Nitric Oxide Interplay in the Roots of Allium cepa L..DOCX by Indrani Manna (10119200)

“…Though initially showing a dose-dependent concomitant rise, a significant decrease of NO was observed at higher concentrations of NiO-NP, while cellular ROS continued to increase. …”

The effect of the third dose of the BNT162b2 vaccine on anti-SARS-CoV-2 spike antibody levels in healthcare workers with and without COVID-19 infection by Blanka Wolszczak-Biedrzycka (14669975)

“…<p>A third (booster) dose of the anti-SARS-CoV-2 vaccine became necessary due to the observed decrease in anti-SARS-CoV-2S antibody levels over time, new mutations, and low global vaccination rates. …”

Data_Sheet_1_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.PDF by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”