Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

A decrease in the amount of HBV nucleocapsids occurs when there is overexpression of singly-spliced2.2 kb RNA <i>in vivo</i>. by Yi-Ling Wang (704612)

Evaluation of ethanol extract of Punica granatum (Pomegranate) peel decrease in viral replication of BoHV-1 in Colorado murine embryos experimentally infected by Eduardo Gimenes Palazzi (5671100)

“…After 18 hours, the females were euthanized in a CO2 chamber, and through the opening in the peritoneum, zygotes were collected and washed with 0.5% pronase solution. …”

HSP90 inhibition by RGRN-305 decreased the gene expression of proinflammatory cytokines induced by SARS-CoV-2 S protein. by Hakim Ben Abdallah (14578241)

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity-5 by Rodrigo A Fuentealba (77901)

“…<p><b>Copyright information:</b></p><p>Taken from "ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity"</p><p>http://www.molecularneurodegeneration.com/content/2/1/14</p><p>Molecular Neurodegeneration 2007;2():14-14.…”

<i>Mycobacterium tuberculosis</i> thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity - Fig 2 by Apurba Sarkar (8399571)

Image_3_Male Sterility of an AHAS-Mutant Induced by Tribenuron-Methyl Solution Correlated With the Decrease of AHAS Activity in Brassica napus L..JPEG by Jinyang Lv (2636881)

Image_4_Male Sterility of an AHAS-Mutant Induced by Tribenuron-Methyl Solution Correlated With the Decrease of AHAS Activity in Brassica napus L..JPEG by Jinyang Lv (2636881)

Image_1_Male Sterility of an AHAS-Mutant Induced by Tribenuron-Methyl Solution Correlated With the Decrease of AHAS Activity in Brassica napus L..JPEG by Jinyang Lv (2636881)

Image_2_Male Sterility of an AHAS-Mutant Induced by Tribenuron-Methyl Solution Correlated With the Decrease of AHAS Activity in Brassica napus L..JPEG by Jinyang Lv (2636881)

HVR1-swap compensatory E1/E2 substitutions typically decrease virus entry dependency on SR-BI. by Christina Holmboe Olesen (11154333)

Flibanserin’s neuroprotective effects are 5-HT_1A receptor-mediated. by Aaron S. Coyner (2889722)

“…<p>(<b>A i</b>) A spider graph representing average right-eye receptor plus values demonstrates that pre-treatment with WAY 100635 prior to 6 mg/kg flibanserin (10 mg/kg WAY + 6 mg/kg Flibanserin, <i>green</i>) decreased average receptor plus thickness as compared to flibanserin-treatment without WAY 100635 (6 mg/kg Flibanserin, <i>blue</i>). …”

Data Figs 4B, 5A, 5B, 5C and 5D. by Mona Estrella Bachmann (13531933)

Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol expo... by Frederik Abel (8452101)

“…Hypoxia increased apoptosis of H9c2 cells (hypoxia: 8.4%±0.6; normoxia: 2.5%±0.1; p<0.0001). RIPC-EVs decreased H9c2 cell apoptosis compared to control (apoptotic ratio: 0.83; p = 0.0429) while Sham-EVs showed no protection (apoptotic ratio: 0.97). …”

Aliskiren decreases fibrosis markers and inhibits changes in apoptosis markers induced by peritoneal dialysis fluids (PDFs) in rat peritoneal mesothelial cells (PMCs). by Juan Pérez-Martínez (324784)

A decrease in the synthesis of all viral proteins in A549 cells infected with PIV5-W3 is observed by 36h p.i. by Dan F. Young (6321425)

<i>T. cruzi</i> PCM abrogates MAP kinase activation and decreased MAP kinase signaling results in inhibition of ctgf/ccn2 expression. by G. Adam Mott (198973)

Seven out of the 11 human cytidine deaminases are more highly expressed in tumor versus normal tissue and their higher expression is correlated with a decrease in survival. by Mason A. McCool (11889842)

The T-type channel antagonist Ni²⁺ decreases adult turtle motoneuron excitability. by Martha Canto-Bustos (634777)

Human disease-causing mutations in <i>LMOD2</i> result in a decrease in mature, but not pre-, mRNA levels when expressed from a construct containing a downstream intron, which is a... by Christopher T. Pappas (8218833)