Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Morphology of rice seedlings treated with different concentrations of 1’,4’-<i>trans</i>-diol-ABA from 0.5 to 8 mg·L–1 under salt stress at day 4. by Yin Jie (21464235)

Percent of land use during the BASE20 and HG-2 (MRI SSP5) scenario along with corresponding mean annual TSS concentration values (mg/L) across all intake locations. by Elly T. Gay (21170097)

Changes of anti-oxidative enzyme and oxidative stress after in a mouse model of kidney fibrosis. by Wencheng Jin (13136262)

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Changes related to kidney staining in UUO mouse model. by Wencheng Jin (13136262)

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Changes associated with kidney fibrosis and effects of MN705 treatment on TGF- by Wencheng Jin (13136262)

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The screening process of MN705. by Wencheng Jin (13136262)

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Changes associated with kidney fibrosis in TGF- by Wencheng Jin (13136262)

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Effect of MN705 treatment on TGF- by Wencheng Jin (13136262)

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Validation of MN705 treatment effects in human proximal tubular epithelial cells during TGF- by Wencheng Jin (13136262)

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Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. by Mercedes García-Roche (6459200)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

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Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

Activation curves of nodes of the model compared with pharmacokinetics of Meth. by Abolhassan Behrouzvaziri (741985)