Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss by Huixia Li (739049)

“…The trabecular bone volume of <i>Atg7</i> cKO mice was significantly lower than that of controls at 5 months of age. This phenotype was attributed to decreased osteoblast formation and matrix mineralization, accompanied with an increased osteoclast number and the extent of the bone surface covered by osteoclasts as well as an elevated secretion of <i>TNFSF11/RANKL</i> (tumor necrosis factor [ligand] superfamily, member 11), and a decrease in <i>TNFRSF11B/OPG</i> (tumor necrosis factor receptor superfamily, member 11b [osteoprotegerin]). …”

Image_1_The Active Sulfate-Reducing Microbial Community in Littoral Sediment of Oligotrophic Lake Constance.TIF by Susanne Wörner (6328553)

“…^-1 and was paralleled by a decrease of 90–100% in methanogenesis as compared to the respective methanogenic controls. …”

Deep Sequencing Analyses of Low Density Microbial Communities: Working at the Boundary of Accurate Microbiota Detection by Giske Biesbroek (104538)

“…With higher dilutions, low abundant species were overrepresented. In samples of <10⁵ bacteria per ml, <em>e.g.</em> DNA <1 pg/µl, microbiota profiling deviated from the original sample and other dilutions showing a significant increase in the taxa Proteobacteria and decrease in Bacteroidetes. …”

PXDN mutant mice reveal impairment in bacterial clearance during acute lung infection. by Ruizheng Shi (5236607)

“…<p><b>(A)</b> Decrease of relative survival rates. PXDN-deficient and C57BL/6 wild-type mice were intratracheally instilled with 7 x 10⁶ of <i>P</i>. …”

Image_2_The Active Sulfate-Reducing Microbial Community in Littoral Sediment of Oligotrophic Lake Constance.TIF by Susanne Wörner (6328553)

“…^-1 and was paralleled by a decrease of 90–100% in methanogenesis as compared to the respective methanogenic controls. …”

ScFv 2LF dissociation rate constants with each LF variant, measured by Biacore experiments. by Philippe Thullier (320909)

“…<p>The five residues whose mutation to alanine resulted in a 3-fold, or larger, decrease of the dissociation constant are shown in bold.…”

Effect of temporal control of the Raf/MEK/ERK pathway on PC12 neurite outgrowth. by Kai Zhang (102844)

“…When the off-time exceeded 45 min, neurite length gradually decreased. ***p<0.001. (C) The average neurite length induced by intermittent light stimulation with a 45-min on-time and various off-times at 27, 45, 75, 135, 315 min. …”

The effect of <i>Rhodiola rosea</i> on NAD⁺ and NADH levels, <i>dilp</i> expression, and protein, fat, and water content. by Samuel E. Schriner (414153)

“…<p>A. Total NAD⁺ content was unaffected by <i>R. rosea</i> feeding, however, <b>B.…”

GSK3β activation is required for HB9 mRNA expression in hNSCs. by Luis Ojeda (208583)

“…(C) Schematic illustration of an engineered inducible lentiviral vector (LVcaGSK3β), which contains RRE (Rev response element), Terminator (SV40 terminator), 5XRE (GAL4 response element), caGSK3β (constitutive active mutant form of the GSK3β, Ser9Ala), SV40 polyA signal, CPPT (central polypurine tract). …”

Flow Increase Is Decisive to Initiate Angiogenesis in Veins Exposed to Altered Hemodynamics by Volker J. Schmidt (313862)

“…Vessel loops were embedded in a fibrin filled chamber and blood flow was measured by means of flow probes immediately after surgery (day 0) and 15 days after loop creation. …”

NPB304 inhibited the MAPK pathway in MCF-7/paclitaxel cells. by Mei Mei (610571)

“…(C) The expression of p-ERK1/2 was decreased in a concentration-dependent manner when MCF-7/paclitaxel cells were treated with 10 to 50 µM U0126 for 24 h. …”

PAX9 is required for human ribosome biogenesis. by Katherine I. Farley-Barnes (9258036)

“…(G) PAX9 depletion in MCF10A cells results in decreased 40S, 60S, and 80S ribosome subunit levels. …”

AKT2 regulated the tumorigenic potential of neuroblastoma cells <i>in vitro</i>. by Jingbo Qiao (382330)

“…<p>(<b>A</b>) AKT2 expression was measured in BE(2)-C/shCON and BE(2)-C/shAKT2 cells by Western blotting and consistent knockdown of AKT2 was confirmed. …”

SM22α KO cardiomyocytes display altered kinetics of cell shortening. by Jun Wu (4002)

“…(C-E) Bar graphs showing decreased TtP (C), increased Dep v (D) and reduced Dep v t (E) in SM22α KO mice (n = 72 cells from 6 WT mice; n = 31 cells from 4 SM22α KO mice). …”

Supplementary Material for: Human Oral Mucosal Stem Cells Reduce Anastomotic Leak in an Animal Model of Colonic Surgery by Kent I. (10699344)

“…The objective of this study was to evaluate whether hOMSC can decrease anastomotic leak rates in a murine model of colon surgery. …”

Upregulation of SgII and SN upon Dsg2 depletion and increased melanoma cell migration upon stimulation with SN. by Wiebke K. Peitsch (173727)

“…However, in confluent cultures harvested after six days amounts of SgII mRNA were equal in the C32 samples (B) and slightly decreased in Dsg2-depleted MeWo (1.3-fold, A). (C) RIA demonstrating marked upregulation of SN in cellular extracts of Dsg2-depleted MeWo (4.42 vs. 2.24 fmol/probe, p = 0.0704) and slight SN increase in Dsg2-depleted C32. …”

Function of <i>i</i>NKT cells in the spleen and liver from <i>Il17rb</i>^−/− and <i>Il15</i>^L117P mice. by Hiroshi Watarai (185010)

“…<p>(A) FACS profile of spleen and liver mononuclear cells in WT, <i>Il17rb</i>^−/− and <i>Il15</i>^L117P mice on a B6 background. …”

In-group social bonding selectively increases inter-status neural synchronization in the rDLPFC. by Jun Ni (68173)

“…Data are plotted as box plots for each condition, with horizontal lines indicating median values, boxes indicating 25% and 75% quartiles and whiskers indicating the 2.5%–97.5% percentile range. Cross symbols in each box represent the mean values. …”

GVHD associated shifts in GSH metabolism in Allo relative to Syn BMT at Day+4. by Jung H. Suh (523844)

“…Green represents metabolites with mean concentrations in Allo mice that are significantly (p>0.5) increased (>25%) over syn mice. …”

Impacts of Human Disturbance on Large Prey Species: Do Behavioral Reactions Translate to Fitness Consequences? by Mathieu Leblond (457233)

“…We hypothesized that human activities and infrastructure cause a decrease in the individual performance of preys because of anthropogenically enhanced predation risk. …”