PEITC inhibits PTP1B with concomitant decrease in cysteinyl thiol. by Miho Yagi (5921252)

Triiodothyroacetic acid (TRIAC), thyroxine (T4) and 3,5,3’-triiodothyronine (T3) levels in plasma of vehicle treated wild type (Wt; TRIAC n = 5; T4 n = 5; T3 n = 5 and TSH n = 4) a... by Soledad Bárez-López (607514)

GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage by Wieslaw M. Kazmierski (1706686)

“…Pan-genotype NS5A inhibitors underpin hugely successful hepatitis C virus (HCV) therapy. …”

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

S5 Fig - by Meghan J. Hirsch (16528311)

Multi-Cilia Cell Hyperplasia Is Due to Mib-Mediated Jagged2a Signaling Pathway via Notch1a and Notch3 Receptors by Ming Ma (43147)

“…RT-PCR of control embryos generates a 230-bp <i>jagged2a</i> fragment, bridging parts of exon 1 and exon 2 at 24 hpf (lane 1) and 48 hpf (lane 5). …”

AIC model selection from the logistic regression models for probability of habitat selection by territorial male wrens (models presented: ΔAIC <5). by Kirsten A. Wilcox (11099051)

HIV-Tat regulates macrophage gene expression in the context of neuroAIDS by Loreto Carvallo (4167607)

“…We found that HIV Tat increased expression of C5, APBA1, and BDNF, and decreased CRLF2. The K50A Tat-mutation dysregulated expression of these genes without affecting the binding of the Tat complex to their gene sequences. …”

Overexpression of Tdp2 was associated with a decrease in HBV CCC DNA. by Xiuji Cui (755449)

cMSC/Collagen Type I gel fabrication. by Melissa A. MacIver (12850566)

Subjects:

MeV induced <i>APOBEC3A</i> upregulation. by Pierre Khalfi (7868252)

Venn diagram representing the RNA sequencing results. by Shyamasree De Majumdar (168216)

“…The arrows ⬇ indicates a lower than 0.5 fold decrease in transcription compared to calibrator; ⬆ indicates a higher than 2 fold transcription compared to calibrator. …”

Additional images of Rad50 and Mre11 colocalization with replicating viral DNA during PCNA-I1 inhibition. by Jessica E. Packard (16641690)

U937 cells line transfected with miR-525-5p decrease VPAC1 protein at 48 h. by Elisa Cocco (362650)

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

DBcAMP and glucagon produces a decrease of peripheral insulin sensitivity. by Rita S. Patarrão (737406)

Depletion of Atg5 inhibits IDN5706-induced autophagy, but not EDEM1 degradation. by Viviana A. Cavieres (500139)

Accumulated immature APP in response to IDN5706 is degraded by Atg5-dependent autophagy. by Viviana A. Cavieres (500139)

Decreased IL-17A production by DGKζ deficient <i>i</i>NKT cells following α-GalCer stimulation in vitro. by Jinhong Wu (424170)

Event probability by age and altitude of residence in patients with COVID-19 pneumonia. by Juan Alonso Leon-Abarca (8308005)

“…<p>Panel A-B show that the probability of intubation was higher for patients with DM up to 50 [at <1500 m] [p<0.05] and 65 years [at >1500 m] [p<0.05]. …”