Spatial information of excitatory neurons in APP/PS1 mice are decreased in dCA1 and vCA1. by Udaysankar Chockanathan (18510288)

“…<p>(A) In dCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.134 ± 0.050, APP/PS1 = 0.132 ± 0.054, p < 0.01, two-sided Wilcoxon rank-sum test, n_C57BL/6 = 229 units from 5 recording sessions, n_APP/PS1 = 124 units from 4 recording sessions). …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

All Ca_V3.3 variants left-shift the voltage dependence of inactivation. by Yousra El Ghaleb (22075892)

Subjects:

Interaction energies of the Ca_V3.3 A398 amino acid substitutions. by Yousra El Ghaleb (22075892)

Subjects:

Fusion protein induction is correlated with a decrease in the level of FasII protein by Alberto Pascual (6762)

Results for the gap decrease. by Jan Wieding (328185)

Decreased nephrin expression. by Sandra Müller-Krebs (485766)

Genes with decreased expression in TGFβ-induced EMT. by Kevin A. Maupin (190060)

Factors associated with stunting in healthy children aged 5 years and less living in Bangui (RCA) by Pascale Vonaesch (149522)

“…<div><p>Stunting remains a major public health concern worldwide. Although its global prevalence is slowly decreasing, the actual number of affected children is still rising in Sub-Saharan Africa. …”

The relative difference between the target dose of plan S₅₀ and base plan (n by Huaqu Zeng (20601563)

“…</b> Among the 21 patients in plan S₅₀, only one showed a decrease in target dose exceeding 2% but remaining below 2.5% compared to the base plan. …”

Substance P decreases PRL immunoreactivity in human epidermis. by Ewan A. Langan (405804)

“…<p>Epidermal PRL IR (black arrows) was examined in full-thickness human skin organ culture. (A) PRL IR in the control group was significantly greater than that in (B) Substance P treated skin. …”

Protective effect of Mel on DNA damage induced by Oxa. by Mohammad Waseem (4264309)

Compatible pollen triggers a decrease in S-RNase transcript levels by a post-transcriptional mechanism. by Bolin Liu (59887)

Respective increase and decrease in Myc and NRF1/TFAM in kidneys from rats administered Tl. by Sho Sugahara (11895828)

Decreased sensitivity to Thaxtomin A (TA) in TA-habituated somaclone RB9. by Nathalie Beaudoin (21537)

Atorvastatin decreases proliferation of breast cancer cells more potently than rosuvastatin. by Colin H. Beckwitt (2037196)

Transfection of inhibitors decrease their corresponding endogenous miRNAs and transfection of mimics increase corresponding miRNAs in SHSY5Y cells. by Yang-ja Lee (125845)

A change in macular pigment optical density volume (MPOV) within 1.5° eccentricity in the eyes that had all measurement data during a postoperative follow-up period of 2 years (35... by Akira Obana (811847)

Data_Sheet_5_Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neu... by Yize Li (471459)

“…Artesunate normalized paclitaxel-related expression changes in DRG mGluR5, NR1, and GluA2, as well as six paclitaxel related neuroinflammation markers. …”