Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Depletion of DOM-A, but not DOM-B affects s-LN_vs maintenance and PDF accumulation. by Zhenxing Liu (399809)

“…Cell number of sLN_vs (marked as square brackets), PDF, PER and TIM levels in sLN_vs were decreased in <i>dom</i> and <i>domA</i> downregulation flies brains (Top right and bottom left panels), while only affected PER and TIM levels in <i>domB</i> downregulation flies (Bottom right panel). …”

Table_1_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.XLSX by Masahiro Yoshikawa (379956)

Image_2_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)

Image_3_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)

Image_1_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)

Ibuprofen and diclofenac decrease migration. by Verena Leidgens (815986)

Hypoxia regulates IGF1 expression through HIF1α, and the inhibition of HIF1α or IGF1R decreased CD133- and Oct4-positive GRPs under hypoxia. by Akiko Murakami (515972)

MSCs decrease lung inflammation. by Konrad Urbanek (439073)

Decreased deaminase activity in A12-infected cells despite a high level of A3B protein. by Noémie Lejeune (9243785)

DataSheet_1_Effectiveness of regdanvimab treatment for SARS-CoV-2 delta variant, which exhibited decreased in vitro activity: a nationwide real-world multicenter cohort study.pdf by Haein Kim (4839594)

“…Background<p>Immune-evading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are emerging continuously. The clinical effectiveness of monoclonal antibody agents that exhibit decreased in vitro activity against SARS-CoV-2 variants needs to be elucidated.…”

Average predicted probabilities for top 5 publications & average initial placement rankings, controlling for ability, as a function of Alma mater ranking. by Sergey V. Popov (6719075)

HDACi decrease NK function. by Matthew Pace (2954127)

MSCs decrease oligodendrocyte death. by Justin D. Glenn (800439)

TH588 effectively decreases cellular survival in heterogeneous neuroendocrine tumor cells. by Elke Tatjana Aristizabal Prada (833927)

Loss of Arid3b in Bone Marrow Results in Decreased B cells. by Jeffrey L. Kurkewich (3044211)

Virucidal activity of LA, SCFA, and succinic acid combinations associated with an optimal vaginal microbiota or BV, representing a non-optimal vaginal microbiota. by Muriel Aldunate (22411177)

Ibuprofen and diclofenac decrease proliferation. by Verena Leidgens (815986)

“…<p>Proliferation was analyzed using crystal violet staining and results were verified via the CyQuant Direct Cell Proliferation assay in HTZ-349. (A) Starting at 72 h, all ibuprofen concentrations (0.5, 1, 2 mM) resulted in significant reduction of HTZ-349 proliferation (compared to non-treated Ctrl, 95% CI, p < 0.05). 2 mM ibuprofen caused significant proliferation inhibition at 24 h (0.01 > p ≤ 0.001) and 48 h (p < 0.0001). …”

of decreased GFR by age and gender. by Hui Song (53547)