Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

Decreased Tks5 expression results in neural crest-derived defects. by Danielle A. Murphy (212554)

“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”

<i>Pw1</i> deletion does not result in significant decrease in oxytocin production and release. by Anne-Lyse Denizot (3170142)

FA decrease in 5STS impaired participants. by Charlotte Bernard (433013)

NAC treatment decreases myeloid differentiation of <i>Ptpn11</i> GOF mutant cells. by Dan Xu (138152)

BA decreases mitochondrial membrane potential and superoxide production after one day of cell culture. by Bandik Föh (602419)

“…<p>(A) Representative contour plots of MT-Green/TMRE-stained B cells after incubation with 0.5 mM BA for 1 day. …”

Tan IIA decreased LPS-induced NF-κB activity in HSC-T6 cells. by Ya-Wei Liu (606320)

Resistance to Pap-A correlates with decreases in PS. by Chelsi D. Cassilly (2793433)

FGF8b decreased GnRH mRNA in GT1-7 cells. by Natasha N. Mott (341221)

SKO mice demonstrate increased cholesterol efflux in whole skin, and decreased cholesterol levels in plasma. by Sabrina N. Dumas (5474456)

Neutrophil activation and recruitment and CXCR2 expression were decreased in antibiotic pre-treated mice. by Koji Watanabe (205444)

Clinical and genetic characteristics of 5 patients harboring mutations in the <i>NR5A1</i> gene. by Jana Malikova (615672)

Subjects:

GAS5 levels are decreased in bladder cancer. by Zhihong Liu (112690)

Scara5 expression decreased during retinopathy. by Luísa Mendes-Jorge (635136)

“…C: The immunolabeling of paraffin-embedded retinal sections with anti-Scara5 antibody confirmed that Scara5 expression decreased throughout the parenchyma. …”

Claudin V is decreased following infection with Mtb. by Amanda S. Latham (12093638)

“…<p>Immunofluorescent staining of guinea pig brain tissue for DAPI (blue) and claudin V (cyan) in vessels was performed. Representative images of the frontal cortex (A–D), cerebral nuclei (F–I), brain stem (K–N), thalamus (P–S), and hippocampus (U–X) 15 days post-infection are shown. …”

Decreasing Fires in Mediterranean Europe - Fig 5 by Marco Turco (3178641)

Ang II decreases brain hemorrhages, delays experimental cerebral malaria and increases survival of mice. by Julio Gallego-Delgado (796586)

Molecular dynamics simulations of the three systems (MMP9-MOL000098, MMP9-MOL000354, MMP9-MOL000422) after 50 ns. by Lefei Yu (12274846)

Molecular dynamics simulations of the three systems (IL-6-MOL000098, IL-6-MOL000354, IL-6-MOL000422) after 50 ns. by Lefei Yu (12274846)