Image_5_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF by Yung-Yu Yang (9343376)

“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”

Exposure to shear stress leads to a decrease in wild-type AQP5 but no change in N228K AQP5 (n = 3; * p<0.05 with ANOVA one-way). by Nadia N. Hansel (359186)

“…<p>Exposure to shear stress leads to a decrease in wild-type AQP5 but no change in N228K AQP5 (n = 3; * p<0.05 with ANOVA one-way).…”

Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA. by Stefano Farioli-Vecchioli (256006)

“…(<b>A</b>) PC12 cells without (white columns) or with expression of exogenous <i>PC3</i> (activated a week before by withdrawal of 2 µg/ml of doxycycline; grey columns) were exposed to NGF (100 ng/ml) for 1 and 48 hours. …”

<i>Vps13</i> mutant flies show a decreased life span, age dependent impairment of locomotor function and neurodegeneration. by Jan J. Vonk (3686662)

Maf1 is a rapamycin-sensitive regulator of RNAP III-mediated tRNA transcription in <i>S</i>. <i>pombe</i>. by Aneeshkumar G. Arimbasseri (840654)

LiCl administered via 0.5% LiCl food pellets for 4 wks decreases the antioxidant stress response. by Christine M. LaPash Daniels (796881)

“…<p>(A) LiCl decreases <i>Nrf2</i> transcripts in hippocampus and cortex of R236H/+ mice (N = 5 male mice per group). …”

The Impact of Prophylactic Dexamethasone on Nausea and Vomiting after Thyroidectomy: A Systematic Review and Meta-Analysis by Zhenhong Zou (645858)

“…The meta-analysis demonstrated a significant decrease in the incidence of PONV (RR 0.52, 95% CI 0.43 to 0.63, <i>P</i><0.00001), the need for rescue anti-emetics (RR 0.42, 95% CI 0.30 to 0.57, <i>P</i><0.00001), post-operative pain scores (WMD –1.17, 95% CI –1.91 to –0.44, <i>P</i> = 0.002), and the need for rescue analgesics (RR 0.65, 95% CI 0.50–0.83, <i>P</i> = 0.0008) in patients receiving dexamethasone compared to placebo, with or without concomitant antiemetics. …”

Missense Variant in MAPK Inactivator <i>PTPN5</i> Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring by Ravi F. Sood (263139)

“…</p><p>Results</p><p>Our study population consisted of 538 adults (median age 40 years) who were predominantly White (76%) males (71%) admitted to our center from 2007–2014 with small-to-moderate-sized burns (median burn size 6% total body surface area). Of 2,146 SNPs tested, a rare missense variant in the <i>PTPN5</i> gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of post-burn HTS (<i>P</i> = 1.3×10⁻⁶). …”

Panel probit models: Dummy variable which takes a value of 1 for a top 5 publication. by Sergey V. Popov (6719075)

Theme 5 results—mortality. by Corey J. A. Bradshaw (8032406)

Therapeutic effects of miR-150-5p inhibition on atherosclerotic lesion development. by Ping-yu Cai (12389929)

Subjects:

Mutation of Ser-473 in GC-A to alanine but not glutamate decreases ANP-stimulated guanylyl cyclase activity. by Andrea R. Yoder (165684)

Decrease of cell viability and alterations of cell membrane permeability by infection with rotavirus isolates. by Carlos A. Guerrero (1264551)

Data for Figs 1A–1I, 2A–2J, 3B–3H, 4A–4L, 5A–5C, 6A–6C, 6E, by Xiaohua Zhang (350570)

DataSheet1_Decreasing incidence and mortality of lung cancer in Hungary between 2011 and 2021 revealed by robust estimates reconciling multiple data sources.ZIP by Gabriella Gálffy (177759)

“…The COVID-19 pandemic resulted in a statistically significant decrease in lung cancer incidence, especially in the 50–59 age group (both sexes).…”

Activation of Wnt/β-catenin signaling decreases mRNA expressions of <i>Scx</i>, <i>Mkx</i> and <i>Tnmd</i> in rat TDCs. by Yasuzumi Kishimoto (4282138)

“…<p>Relative expressions of <i>Axin2</i>, <i>Scx</i>, <i>Mkx</i>, and <i>Tnmd</i> in TDCs treated with 50 ng/ml Wnt3a with or without 5 μM IWR (an inhibitor of β-catenin) <b>(A)</b>, 0 to 4 μM BIO (an activator of β-catenin) <b>(B)</b>, or 0 to 20 μM IWR <b>(C)</b> for 72 hrs. …”

DataSheet2_Decreasing incidence and mortality of lung cancer in Hungary between 2011 and 2021 revealed by robust estimates reconciling multiple data sources.xlsx by Gabriella Gálffy (177759)

“…The COVID-19 pandemic resulted in a statistically significant decrease in lung cancer incidence, especially in the 50–59 age group (both sexes).…”

Schematic illustration of the prediction model for all the five vignettes. by Michelle Dey (525235)

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…The complexes demonstrated submicromolar cytotoxic activity against human breast cancer cells MDA-MB-231 or MDA-MB-468 with IC₅₀’s in the range of 0.4–5.0 μM. Complex <b>2e</b> shows high potency in vitro and decreases 3D-breast cancer mammosphere viability. …”

Glucose decreases the ability of HNF4α to activate the transcription of the <i>NR2F2</i> proximal promoter and to bind its chromatin target. by Marie Boutant (164748)