Image8_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image9_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image5_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image7_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image11_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image10_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Data Sheet 1_Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction.pdf by Jing J. Zhang (20561426)

“…Echocardiography revealed that the 250-ng group had consistently higher contractile function and lower left ventricular (LV) dilatation than the saline control over 6 weeks while ≥1,000-ng groups exhibited transient lower LV ejection fraction at 5 days post-MI in vivo. …”

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion by Akram Torki (5383154)

“…Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. …”

Promoter analysis of mouse <i>Mogat1</i>. by Shireesha Sankella (3111030)

“…</b> This region silences/reduces (2-fold) the promoter activity when inserted 5’ to the SV40 promoter Bars represent mean±SEM, n = 4, performed in duplicate. …”

<i>P</i>. <i>aeruginosa</i> secreted virulence factors induce ER stress in primary bronchial epithelial cells. by Emily F. A. van ‘t Wout (756193)

“…Time-dependent induction of ER stress in primary bronchial epithelial cells, as assessed by <i>XBP1</i> splicing, <i>CHOP</i> and <i>GADD34</i> mRNA after treatment with CM-PAO1 (n = 5; mean ± SEM). B. Dose-response of spliced <i>XBP1</i>, <i>CHOP</i> and <i>GADD34</i> mRNA in primary bronchial epithelial cells treated with CM-PAO1 for 12 hours (n = 5; mean ± SEM). …”

Lack of PRLR impaired brown adipose tissue development in newborns. by Say Viengchareun (39121)

“…Adipocyte cell surface was calculated using the Lucia software and a significant decreased was detected in PRLR KO mice (n = 5) <i>vs</i> controls (n = 5) (***p<0.001, n = 200 cells /group). …”

NMDA does not alter PPR but does potentiate postsynaptic responses to glycine. by Michelle L. Kloc (7359230)

“…Paired pulse ratio does not decrease after NMDA-induced potentiation. Top, average of 5 IPSCs from a single experiment before (black) and 5 min after NMDA (blue). …”

Image_3_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_7_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_1_Post-eastern Mediterranean Transient Oxygen Decline in the Deep Waters of the Southeast Mediterranean Sea Supports Weakening of Ventilation Rates.jpeg by Guy Sisma-Ventura (6504992)

“…Multiannual variability in oxygen levels superimposed this trend, and is likely associated with variations in thermohaline fluxes. The 2020 mean oxygen concentration of 179.5 ± 2.3 μmol kg⁻¹ is comparable to the pre-Eastern Mediterranean Transient (EMT) mean value. …”

Effect of breathing hypoxic gas on vascular oxygenation of 4T1 and 4T07 tumors. by Narasimhan Rajaram (474255)

“…</b> 24 hours after breathing hypoxic gas, there was a significant decrease in SO₂ of the 4T1 tumors (n = 4; p = 0.04), which had returned to a mean value close to pre-hypoxia baseline. 1 animal had to be censored before the 24 hours post-hypoxia measurement. …”

Image_2_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_6_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_1_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Summary of responses to free-flight antennal stimulation of extrinsic antennal muscles in six animals. by Armin J. Hinterwirth (109677)

“…Similarly, the Δ_speed column indicates changes in the mean body speed before and after stimulus onset. (+ +: >1 m/s²; −: <−0.5 m/s²; − −: <−1 m/s²; − − −: <−1.5 m/s²(max. was −2.8 m/s²). …”