Lysosomal translocation of GAPDH-HT reflects CMA activity in HeLa cells. by Takahiro Seki (185432)

“…The percentage of GAPDH-HT dot-positive cells and the number of GADPH-HT dots per cell were significantly decreased by siRNA-mediated LAMP2A-knockdown. ** p<0.001 vs cells treated with nontargeting-siRNA (unpaired <i>t</i>-test, n = 16 in <i>B</i>, n = 57 for nontargeting-siRNA and n = 74 for LAMP2A-siRNA in <i>C</i>). …”

Data Sheet 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.docx by Lanlan Sun (1798921)

“…Additionally, the combination of CSA and Clo reduced MDA levels by 13.4%, increased SOD activity by 9.7% and GST activity by 26.7%, while elevating GSSG content by 31.3% compared to Clo alone, ultimately mitigating oxidative damage in maize plants. qRT-PCR analysis showed that the expression of five P450 genes (CYP72A5, CYP81A4, CYP81Q32, CYP81A9, CYP81A36), nine GST genes (GST30, GST31, GSTIV, GSTVI, GST21, GST7, GST37, GST25, IN2-1), and two UGT genes (UGT76C2, UGT83A1) significantly high increased by 6.74-, 10.27-, 4.98-, 10.56-, 25.67-, 16.70-, 46.92-,7.53-, 5.10-, 238.82-, 143.50-, 4.58-, 31.51-, 39.3-, 4.20-, 10.47-fold after CSA+Clo treatment compared to that in the Clo treatment. …”

Both GBP1 and GBP2 are secreted from the fat body and directly act on the brain to induce ILP2 and ILP5 secretion. by Takashi Koyama (417981)

“…<p><b>(A, B)</b> Culturing wild-type brains with conditioned media from GBP1 and GBP2 expressing cells induces low level of ILP2 (A) and ILP5 (B) accumulation in the insulin-producing cells. …”

Loss of Alkbh4 reduces the size of testes and the diameter of seminiferious tubuli. by Anja Nilsen (238278)

“…Data are expressed as means ± SEM. <b>C</b> High magnification view (scale bar, 20 µm) of testis section in B. …”

Figure 1; Figure 2; Figure 3; Figure 4; Figure 5; Table 1; Table 2; Table 3; Table 4; SupTable 1; SupTable 2; SupTable 3 by Ramachandran Chelliah (3837415)

“…</b> <b>Canonical NF-κB activation pathway and its transcriptional role in inflammation-associated bone loss:</b> In resting cells, the NF-κB complex (typically RelA/p50) is sequestered in the cytoplasm by IκBα. …”

Precision and lower limit of detection. by Melinda L. Tursky (20790436)

“…LLOD was therefore set at VAF ≥ 0.004. G: The detection of five rare clones (<0.005 VAF) identified in blood samples from community-dwelling subjects sequenced at a mean depth of 3485 × with a UAO filter of ≥ 3 were independently validated by ultra-sensitive ddPCR. …”

Anti-angiogenic effect of bevacizumab and anti-invasiveness effect of Ad-SGE-REIC. by Yasuhiko Hattori (8675172)

“…The invasiveness was assessed by the distance between the tumor mass edge and the invasive lesion. Values are the mean ± standard deviation (SD) from five independent experiments. …”

GnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression by Jun Tan (46388)

“…Moreover, we also found a decreased expression and phosphorylation of c-kit receptor in decidualized hESCs after treating with GnRH-ant. …”

Image_1_Fermentation weight loss, fermentation quality, and bacterial community of ensiling of sweet sorghum with lactic acid bacteria at different silo densities.pdf by Haiwen Xu (10453244)

“…Overall, sweet sorghum silage showed satisfactory fermentation quality, with a density of no <650 kg/m³, and inoculating LAB improved fermentation quality and reduced FWL. …”

Data_Sheet_1_Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine... by Tong Li (206968)

“…To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a basal diet plus all-rac-α-tocopheryl acetate (50 mg/kg), Se (sodium selenite at 0.3 mg/kg), or both of these nutrients were provided to day-old broiler chicks (n = 40/group) for 6 weeks. …”

Image_2_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Table_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Image_3_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Data_Sheet_2_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Image_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Data_Sheet_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Simultaneous monitoring of cellular key characteristics during epithelial wound closure illustrated by results from a single measurement. by Dominik Bettenworth (626384)

“…(<b>C</b>) The average cell layer thickness as well as temporal thickness increase of mitomycin c-treated and unstimulated control was comparable while EGF-stimulated cell show a dramatically increased cell layer thickness that slightly decreased during the observation period. (<b>D</b>) The cellular volume <i>V</i> of mitomycin c-stimulated cells was constant during the 40 h observation period. …”

The ancestral mutant telomerase affects repeat addition processivity <i>in vitro</i>. by Jonathan K. Alder (225759)

“…Telomerase activity assay at high nucleotide (1 mM) concentrations on the left shows no defects in catalytic activity or processivity for hTERT V791I and V867M or the double mutant. At lower nucleotide concentration (10 µM), hTERT 867M and hTERT V791I-V867M both show defects in repeat addition processivity as evidenced by the decreased intensity of the high molecular weight products relative to the first repeat. …”

Increased CPEB4 protein level in most HCC specimens. by Li-Yun Tsai (503512)

“…(D) Fold change in CPEB4 and E-cad expression (T vs N) in each patient log2 transformed and plotted by tumor stage. Five of 8 CPEB4-downregulated samples with decreased expression of E-cadherin were denoted with number signs (#). …”

<i>In vitro</i> models of SMC phenotypic change. by Núria Coll-Bonfill (3151767)

“…Data are expressed as the mean ± SEM of five independent experiments performed in duplicate. …”