Image_5_Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host.tif by E. Yaneth Osorio (9226059)

Directed evolution of HIV-1 to utilize CD4^low target cells. by David Beauparlant (3491435)

“…<b>(E)</b> Adaptation to CD4^low target cells results in high resistance to CD4 inhibitor compared to wild type HIV-1 isolates. Comparison of IC50 of CD4-blocking DARPin 55.2 against 41 wild-type HIV-1 strains from different clades (black dots, see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006255#ppat.1006255.s003" target="_blank">S3 Table</a> for details on virus panel and individual IC50 values) and the CD4^low adaptation virus panel (colored dots, see legend) probed by Env pseudovirus infection on TZM-bl cells. …”

The pulmonary hemodynamics and the fluctuation in the serum antibody levels against EXD2 and PHAX peptides in patients with CTEPH before and one year after pulmonary endarterectomy... by Akira Naito (663843)

“…<p>The mean pulmonary artery pressure decreased from 45.5±10.9 to 25.3±7.4 mmHg and the pulmonary vascular resistance decreaseased from 732.0±287.4 to 322.1±157.2 dyne·sec·cm^-5. …”

Mendelian randomization results with COVID-19. by Alish B. Palmos (5857379)

Schematic diagram of STTFP model. by Guozhu Sui (21672798)

Expression of CRYAB in normal and tumor tissue samples across different cancer types. by Rasool Saghaleyni (10526301)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Dysregulated alternative splicing in DM1 hiNeurons at 10 DPI. by Mougina K. Eltahir (12988153)

“…(d) Scatter plots pertaining to Fig 5c show decreased inclusion of <i>MAPT</i> e2 (top), <i>CSNK1D</i> e9 (bottom left) and <i>MPRIP</i> e9 (bottom right) in DM1 hiNeurons. …”

Effect of obesity on contraction of mesenteric arteries to angiotensin II and norepinephrine. by Graziela N. Hagihara (623403)

Contribution of angiotensin II receptors activation to the vascular effects of angiotensin. by Graziela N. Hagihara (623403)

Effect of angiotensin II on eNOS phosphorylation in mesenteric arteries. by Graziela N. Hagihara (623403)

Activation of deep SC neurons recapitulates delayed LER in <i>Setd5</i>^<i>+/−</i> animals. by Laura E. Burnett (18794525)

“…(<b>I</b>) Proportion of trials at different laser intensities that either show an increase (white), decrease (black), or no change (grey) in speed upon light activation for <i>Setd5</i>^+/+ (top) and <i>Setd5</i>^+/<i>−</i> (bottom). 0.01 mW mm⁻²: 35 trials, <i>p</i> = 0.649; 0.5 mW mm⁻²: 111 trials, <i>p</i> = 0.193; 5 mW mm⁻²: 50 trials, <i>p</i> < 0.001; 10 mW mm⁻²: 49 trials, <i>p</i> < 0.001; 15 mW mm⁻²: 61 trials, <i>p</i> = 0.004; 20 mW mm⁻²: 49 trials, <i>p</i> < 0.001, X² test of independence. …”

Image_5_Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain.TIF by Hélène David (8402883)

“…Acute LV dysfunction was associated with global hypoxia, specifically a decrease in sO₂ level in the brain (−5.9%), kidney (−6.4%), and liver (−7.3%) at 4 and 24 h post-MI. …”

miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions by Eva Maria Pinatel (506111)

A deficiency of TLR9 decreases chronic stress-induced changes of pro-inflammatory cytokine levels by macrophages TLR9 knockout mice or wild type BALB/c mice aged 6 to 8 weeks were... by Yanxiao Xiang (468904)

Effects of angiotensin II on ERK 1/2 phosphorylation in mesenteric arteries. by Graziela N. Hagihara (623403)

Phenotypic characterization of <i>CsIVP</i>-RNAi transgenic plants. by Shuangshuang Yan (798064)

“…<p>(A) Plant morphology of WT and <i>CsIVP-</i>RNAi lines R5, R3, and R2. …”