Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action by Fernanda Fonseca-Silva (356488)

“…</p><p>Methodology/Principal Finding</p><p>Apigenin reduced the infection index in a dose-dependent manner, with IC₅₀ values of 4.3 μM and a selectivity index of 18.2. …”

Theoretical models of patterns of change in mean and variance. by Jewel Gausman (5210969)

RNAi of electron transport chain components in glutamate neurons decreases nighttime activity in 10 day old flies. by Jessie E. Landis (16378731)

Imatinib or masitinib decreases cell surface expression of mature c-Kit in UT-7/Epo cell line. by Diane D'allard (405441)

Thymoquinone decreases clinical symptoms, plasma MMCP-1 levels, and mast cell numbers in OVA-allergic mice. by Swantje C. Duncker (154707)

Knockdown of CoREST1 decreased tumor cell-mediated stimulation of endothelial cells <i>in vitro</i>. by Sohini Mazumdar (707540)

Decreased MBP levels in the brain in <i>Large</i>^{<i>myd/myd</i>} mice. by Shigefumi Morioka (8893511)

“…The results are presented as the mean of at least three experiments. <b>B,</b> Whole-brain lysates of P7 control and <i>Large</i>^{<i>myd/myd</i>} mice (<i>n</i> = 5) were obtained for MBP immunoblotting. …”

Decreased striatal Drd1 mRNA expression during the early, but not late, phase of motor skill learning. by Yu Qian (153240)

Leptin Decreases FoxO3a Activity and Increases PGC-1α Protein in Gastrocnemius Muscle. by Neira Sáinz (260167)

EMS decreases female fecundity and <i>Wolbachia</i> titre in the next generation in a dose-dependent manner. by Elves H. Duarte (10994504)

Expression of CavY14F mutant decreases IGF-IR internalization in IGF1 stimulated cells. by Barbara Salani (359372)

Decreased expression of tight junction proteins and disruption of intestinal barrier integrity in DSS-induced colitis mouse model. by Mariam Wed Eladham (21439745)

Overexpressed SPARC in gastric cancer cell lines decreases angiogenesis <i>in vitro</i> and <i>in vivo</i>. by Jun-Ling Zhang (308850)

miRNAs targeting hTERT decrease cell proliferation in the DLD-1 and MCF-7 cell lines. by Radmila Hrdličková (523455)

Inhibiting Gamma-secretase activity without interfering in Notch signaling: Decreasing the inflammatory response in patients with cutaneous leishmaniasis by Lucas Carvalho (3093042)

“…The black line on the violin plot represents the percentile 50th and the dashed lines, 25th and 75th percentiles, respectively. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

PAC-1 activation counteracts impaired NSCs under hypoglycaemic <i>milieu via</i> the PKA-dependent pathway. by Shiva Mansouri (2838086)