Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Real-world mepolizumab treatment in patients with severe asthma decreased exacerbations, oral corticosteroid use, and healthcare resource utilization and costs over 4 years: a retr... by Wendy C. Moore (10682686)

“…</p> <p>Among 189 eligible patients, mean asthma exacerbation rate (AER) declined progressively from baseline during follow-up: AER decreased by 53.8% at Year 1 and 73.8% by Year 4 (<i>p</i> < 0.001). …”

Number of bars of length greater than <i>ℓ</i> = 4000 in the barcodes obtained via the binary model (left) and the fuzzy binary model (right) as a function of <i>τ</i>. by Samir Chowdhury (5715338)

KSHV miRNA cluster induces aerobic glycolysis and stabilizes HIF 1 alpha. by Ohad Yogev (252095)

Mucin deglycosylase activity of ChiA2. by Moumita Mondal (632557)

“…A 50-fold decrease in the % area density of the spot was observed for ChiA2-treated rabbit mucin compared to the untreated one. …”

Effect of HPMC/GSNO on the nitrite/nitrate (NOX) levels in experimental periodontitis in rats. by Conceição S. Martins (468492)

Effect of topical application of HPMC/GSNO solutions on the plasma bone alkaline phosphatase (BAP) in experimental periodontitis in rats. by Conceição S. Martins (468492)

Quantification of iNOS, RANK, TRAP and nitrotyrosine immunostainning in periodontal tissue of rats submitted to experimental periodontitis. by Conceição S. Martins (468492)

Effect of topical application of HPMC/GSNO solutions on alveolar bone loss in experimental periodontitis. by Conceição S. Martins (468492)

FldP decreases the H₂O₂-induced mutation frequency in <i>mutT</i>-deficient <i>P. aeruginosa</i>. by Alejandro J. Moyano (186752)

Effect of HPMC/GSNO on tumor necrosis factor alpha (TNF-α; A) and interleukin-1β (IL-1β; B) in experimental periodontitis in rats. by Conceição S. Martins (468492)

Effect of the topical application of HPMC/GSNO solutions on the oxidative stress markers malonaldehyde (MDA; A) and reduced glutathione (GSH; B) in experimental periodontitis in ra... by Conceição S. Martins (468492)

Effect of HPMC/GSNO on tumor necrosis factor alpha (TNF-α; A), RANK (B) and on the ratio RANKL/OPG (C) mRNA levels in experimental periodontitis in rats. by Conceição S. Martins (468492)

Triclosan Dioxygenase: A Novel Two-component Rieske Nonheme Iron Ring-hydroxylating Dioxygenase Initiates Triclosan Degradation by Yiran Yin (19144130)

“…The highest amino acid identity of TcsA and the large subunits of other dioxygenases in the same family was only 35.50%, indicating that TcsAB is a novel dioxygenase. …”

Expression of the KSHV miRNA cluster reduces mitochondrial biogenesis. by Ohad Yogev (252095)

Gene expression analysis of T3-regulated genes in the cerebral cortex of vehicle treated Wt (<i>Hr</i> n = 4; <i>Cbr2</i> n = 4; <i>Flywch2</i> n = 3; <i>Dio3</i> n = 4; <i>Abcd2</... by Soledad Bárez-López (607514)

Anti TK1-sdAb-Fc antibodies elicit ADCC responses against NCI-H460 cells expressing mTK1. by Edwin J. Velazquez (8724405)