Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…Treatment of such diseases with small-molecule NIK inhibitors is a reasonable but underexplored approach. In this paper, we reported the discovery of a potent and selective NIK inhibitor <b>46</b> (XT2). …”

Crz1 mediates masking in response to exogenous calcium. by Andrew S. Wagner (11331477)

Additional <i>Setd5</i> behavioural controls. by Laura E. Burnett (18794525)

“…<b>(A</b>) Average speed during prestimulus exploration (<i>Setd5</i>^+/+, 7.50 cm s⁻¹; <i>Setd5</i>^+/−, 6.65 cm s⁻¹, <i>P</i> = 0.151). …”

Chlorogenic acid (CGA) metabolites-containing serum from CGA-treated normal mice decreases lipid accumulation and stimulates cholesterol efflux from RAW264.7 cells. by Chongming Wu (169161)

“…<p>Normal C57BL/6J mice were orally gavaged with 400 mg/kg of CGA or equal volume of distilled water for 3 days and blood was collected at 45 min after the final treatment. 1% (v/v) of serum from CGA-treated normal mice (S_CGA) significantly decreased oxLDL-induced neutral lipid accumulation (A) and total cholesterol (B), and stimulates cholesterol efflux (C) in RAW264.7 cells as compared with that from distilled water-treated animals (S_NC). …”

Elf5 can inhibit epidermal keratinocyte proliferation. by Anhua Hu (4805145)

“…<p>(<b>a-d</b>) RT-qPCR analysis of Elf5 and cell cycle gene markers in PMEKs showed an increase and/or decrease in the expression of genes analysed after modulation of Elf5 activities, respectively. …”

The functions <i>G</i>_<i>k</i>(<i>L</i>) representing the <i>k</i>-components of the flow depending on the scale of coarse-graining <i>L</i>. by Vladimir A. Andryushchenko (4662829)

Trends in cutting performance with different chip shapes. by Zhaolong Zhu (5746550)

Silencing or suppression of TRPM7 inhibits cortical astrocyte proliferation. by Zhao Zeng (478844)

“…<p><b>A</b>. Representative images show the proliferation of astrocytes treated with control siRNA or TRPM7 siRNA. …”

House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 by Do Hyung Kim (739231)

Membrane-localized AR facilitates productive endocytosis and nuclear trafficking of KSHV. by Xing Wang (154377)

“…Cells were performed as mentioned above, except lacking of Triton X-100 treatment in non-permeabilized group. Scale bars represent 50 μm. (c) Knockdown of AR and EphA2 expression reduces KSHV endocytosis, as indicated by decreasing gB staining in cells. …”

Model of miRNA involvement in muscle response following BoNT/A-induced muscle paralysis. by Leah E. Worton (457030)

Snow water equivalent (W) of different kind of sites (control, low burn severity, high burn severity). by Tongxin Hu (4217563)

Snow-covering and snow-free soil temperature (T) in (a) control, (b) low burn severity, and (c) high burn severity. by Tongxin Hu (4217563)

Expression of Ring1B is influenced by the 5′ UTR. by Erwin Boutsma (377558)

“…One can clearly appreciate the increased exogenous Ring1B protein levels relative to tubulin when the 5′ UTR is present, as well as the decreased protein levels when the stem-loop-stem hairpin is cloned in front of the 5′ UTR, and the absence of exogenous Ring1B protein when the CMV promoter was removed from the vector. …”

The parameters and statistics of soil respiration as the exponential function of soil temperature at growing season, non-growing season snow-covering, and non-growing season snow-f... by Tongxin Hu (4217563)

Snow-covering and snow-free soil respiration (Rs) in (a) control, (b) low burn severity, and (c) high burn severity treatments. by Tongxin Hu (4217563)

Annual (a) soil respiration (Rs), (b) soil temperature (T) of different kinds of sites (control, low burn severity, high burn severity). by Tongxin Hu (4217563)

Oral normal keratinocyte was treated with DSF at the indicated concentrations (0.5–5 μM) and cell viability was measured by CCK-8 assay. by Young Min Park (101809)

“…<p>A marked decrease in viability mediated by DSF was noted at 0.5 μg/mL in oral normal keratinocyte. …”

Venn diagram representing the RNA sequencing results. by Shyamasree De Majumdar (168216)

TRPM7 is down-regulated in mouse cortical astrocytes by siRNA. by Zhao Zeng (478844)

“…<p><b>A</b>. RT-PCR shows that transfection of astrocytes with specific TRPM7 siRNA decreases the mRNA level of TRPM7 compared to those with control siRNA. …”