Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis by Bongkochawan Pakamwong (12315428)

“…Models of complexes of compounds <b>G24</b> and <b>G26</b> bound to the M. tuberculosis DNA gyrase ATP-binding site, generated by molecular dynamics simulations followed by pharmacophore mapping analysis, showed hydrophobic interactions of inhibitor hydrophobic headgroups and electrostatic and hydrogen bond interactions of the polar tails, which are likely to be important for their inhibition. Decreasing compound lipophilicity by increasing the polarity of these tails then presents a likely route to improving the solubility and activity. …”

Pichia kudriavzevii yeast as biocatalizer in Reactive Black 5 by Elina Isaque Delane (8743299)

“…Thus, the objective of this work was to study the discoloration of the Reactive Black 5 (RB5) azo dye by the yeast Pichia kudriavzevii SD5. …”

Mean threshold current levels needed to evoke forelimb movements on stimulation of the right cerebral motor cortex. by Yuling Meng (197797)

“…After TBI, the contralateral movement threshold (for left normal forelimb) was unchanged, whereas the ipsilateral movement threshold was decreased significantly at 5 weeks postinjury compared to sham (<i>p</i><0.05). tPA treatment further reduced the threshold current needed for ipsilateral forelimb movement compared to the saline controls (<i>p</i><0.05). …”

Fig 3 - by Masaru Sakai (1669627)

Immunoblot images of α-SMA, PCNA and Sirt1. by Hanhan Liu (568151)

Absence of Jag2 alleviates hypoxia-induced oxidative stress injury in rats. by Hanhan Liu (568151)

Jag2 knockdown ameliorates mitochondrial dysfunction induced by hypoxia. by Hanhan Liu (568151)

Mutation prevalence of <i>podhfr</i>, <i>pocrt</i> and <i>pocytb</i> in <i>P</i>. <i>ovale curtisi</i> and <i>P</i>. <i>ovale wallikeri</i> isolates. by Jing Chen (4762)

Jag2 deficiency prevents proliferation and promotes apoptosis in hypoxia-treated PASMCs. by Hanhan Liu (568151)

Global effects of RG108 on DNA modifications and DNMTs and TETs enzymatic activities in hBMSCs. by Rahyza I. F. Assis (6037928)

“…(A) Global methylation was assessed using Imprint Methylated DNA Quantification Kit showing a significant decrease in the RG108 group. …”

Jag2 expression is upregulated in hypoxia-treated rats and PASMCs. by Hanhan Liu (568151)

The expected heterozygosity <i>(H</i>_<i>e</i>) of microsatellite loci flanking <i>podhfr</i> gene in <i>P</i>. <i>ovale curtisi</i>. by Jing Chen (4762)

Jag2 regulates mitochondrial injury in hypoxia-induced PASMCs via Sirt1 signaling. by Hanhan Liu (568151)

The inactivation of <i>Kdm6a</i> in mice had age- and gender-dependent effects on normal hematopoiesis. by Ling Tian (107492)

“…Aged KO-F mice developed a mild macrocytic anemia, which was characterized by decreased hemoglobin (Hb: 11.5 g/dL in KO-F mice vs. 14.28 g/dL in WT-F mice, p = 0.0137) with an increased mean corpuscular volume (MCV: 51 fL in KO-F mice vs. 40.55 fL in WT-F mice, p = 0.0001) and mean corpuscular hemoglobin (MCH: 15.15 pg in KO-F mice vs. 12.85 pg in WT-F mice, p = 0.0004). …”

Differential expression of growth-promoting and growth-inhibiting genes optimizes biomass production and seed yield. by Sreya Das (20531295)

5-FU nanoparticle had liver-targeting and enhanced 5-FU to inhibit the growth of hepatic caner through ASGPR <i>in vivo</i>. by Mingrong Cheng (302795)

“…(B) 5-FU concentration in different tissues in mice were treated with i.v. 5-FU, CS/5-FU or GC/5-FU or, 5-FU determined 30 min post-injection. …”

Dynamics of PIF4 protein accumulation and autoinhibition in response to temperature. by Sreya Das (20531295)

Supplementary file 1_Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation.docx by Huan Ma (713125)

“…</p>Results<p>Among 3,655 sepsis patients from the FAH-SYSU dataset, we identified 5 distinct clusters of BG trajectories, which were significantly associated with 1-year mortality risk. …”

Serum syndecan-1 concentration. by Hiroki Iwata (2434012)

An example of the empirical choice patterns and the mean choice percentage of consumed pellets by food location, flavor, and rank. by Kanghoon Jung (501555)

“…Choice percentage linearly decreases as a function of log(rank order). The dotted line is the log-linear fit (the slope  = −70.7±4.95 [mean ± s.e.m], adj. …”