Search alternatives:
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
-
12061
-
12062
-
12063
-
12064
-
12065
-
12066
-
12067
Shape-Based Reprofiling of FDA-Approved Drugs for the H<sub>1</sub> Histamine Receptor
Published 2012“…Reprofiling of existing drugs to treat conditions not originally targeted is an attractive means of addressing the problem of a decreasing stream of approved drugs. To determine if 3D shape similarity can be used to rationalize an otherwise serendipitous process, we employed 3D shape-based virtual screening to reprofile existing FDA-approved drugs. …”
-
12068
Elevated Ca<sup>2+</sup> entry through VGCCs increases the EPSC amplitude and accelerates synaptic depression.
Published 2019“…Continuous line, linear regression of the last 5 data points to estimate the initial RRP size (shown in panel F). …”
-
12069
-
12070
-
12071
Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor
Published 2017“…Lv-mirAT1 treatment decreased <i>At1</i> gene expression in 50% and reduced fibrosis to 7% 30 days after. …”
-
12072
-
12073
-
12074
-
12075
-
12076
TRPC channels modulate the vesicle replenishment rate and the RRP size.
Published 2019“…<p>(A) Exemplary EPSCs triggered by HFS (20 Hz, 40 AP/2 s) of autaptic wt and TRPC1/C4/C5 tko neurons (inset magnified view on the first 4 EPSCs of the train response. …”
-
12077
TRPC channels augment the presynaptic Ca<sup>2+</sup>-rise upon HFS.
Published 2019“…(D) Maximum ΔF/F<sub>0</sub> from the data shown in (C), tko, <i>p</i> = 0.006; +C1, <i>p</i> = 0.0076; +C5, <i>p</i> = 0.0023. (E) TRPC deficiency decreases, whereas TRPC expression increases the slope of ΔF/F<sub>0</sub> during HFS (slope between the 6th and the 13th data point; tko, <i>p</i> = 0.003; +C1, <i>p</i> = 0.035; +C5, <i>p</i> = 0.002. …”
-
12078
-
12079
-
12080