Showing 12,061 - 12,080 results of 45,491 for search '(( 5 ((ng decrease) OR (mean decrease)) ) OR ( 50 ((we decrease) OR (a decrease)) ))', query time: 0.76s Refine Results
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    Shape-Based Reprofiling of FDA-Approved Drugs for the H<sub>1</sub> Histamine Receptor by Sridhar R. Vasudevan (589877)

    Published 2012
    “…Reprofiling of existing drugs to treat conditions not originally targeted is an attractive means of addressing the problem of a decreasing stream of approved drugs. To determine if 3D shape similarity can be used to rationalize an otherwise serendipitous process, we employed 3D shape-based virtual screening to reprofile existing FDA-approved drugs. …”
  8. 12068

    Elevated Ca<sup>2+</sup> entry through VGCCs increases the EPSC amplitude and accelerates synaptic depression. by Yvonne Schwarz (7406756)

    Published 2019
    “…Continuous line, linear regression of the last 5 data points to estimate the initial RRP size (shown in panel F). …”
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    Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor by Roberta Sessa Stilhano (328847)

    Published 2017
    “…Lv-mirAT1 treatment decreased <i>At1</i> gene expression in 50% and reduced fibrosis to 7% 30 days after. …”
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    TRPC channels modulate the vesicle replenishment rate and the RRP size. by Yvonne Schwarz (7406756)

    Published 2019
    “…<p>(A) Exemplary EPSCs triggered by HFS (20 Hz, 40 AP/2 s) of autaptic wt and TRPC1/C4/C5 tko neurons (inset magnified view on the first 4 EPSCs of the train response. …”
  17. 12077

    TRPC channels augment the presynaptic Ca<sup>2+</sup>-rise upon HFS. by Yvonne Schwarz (7406756)

    Published 2019
    “…(D) Maximum ΔF/F<sub>0</sub> from the data shown in (C), tko, <i>p</i> = 0.006; +C1, <i>p</i> = 0.0076; +C5, <i>p</i> = 0.0023. (E) TRPC deficiency decreases, whereas TRPC expression increases the slope of ΔF/F<sub>0</sub> during HFS (slope between the 6th and the 13th data point; tko, <i>p</i> = 0.003; +C1, <i>p</i> = 0.035; +C5, <i>p</i> = 0.002. …”
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