Dual transfection of <i>gp70</i> and <i>Mcm2</i> enhances DNA-damage-induced apoptosis in 3T3 cells. by Shinya Abe (154673)

“…Cell survival is significantly different between control cells “<i>gp70</i> (−), <i>Mcm2</i> (−)” and <i>gp70/Mcm2</i>-transfected cells “<i>gp70</i> (+), <i>Mcm2</i> (+)” (#<i>p</i><0.01). Data represent the mean and 95% CI of 3 independent experiments. (<b>C</b>) Apoptotic cell ratios in <i>gp70</i> and/or <i>Mcm2</i>-transfected 3T3 cells were determined with annexin V-staining after treatment with 1 µM doxorubicin for 24 h. …”

The effect of stress on sound processing increases with repeated exposure. by Ghattas Bisharat (20706928)

“…Values represent mean ± SE. (b) Change in activity per tracked cell in response to a 50 dB noise is defined as the slope of a linear fit of the mean activity of the baseline days and activity on days 1, 3, and 5 of stress (examples of the linear fit on the right). …”

The effector functions of CHK-152 contribute to protection <i>in vivo</i>. by Pankaj Pal (404355)

“…No statistically significant differences between ch-CHK-152 and ch-CHK-152 N297Q were observed with the 25 µg dose. Of note, we observed a reproducible decrease in clinical score on day 5 in many animals. …”

Sensitivity of retinal endothelial cells by FP59 and LeTx <i>in vitro</i> and <i>in vivo</i>. by Jennifer L. Bromberg-White (259780)

“…<p>(A, B) To assess the sensitivity of retinal endothelial cells (REC) to FP59 or LeTx <i>in vitro</i>, REC (◊) or SK-MEL-28 (▴) were treated with (A) PA (1 µg/mL) and FP59 (10 ng/mL to 10,000 ng/mL), or (B) PA (1 µg/mL) and LF (10 ng/mL to 10,000 ng/mL). …”

Table_2_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.XLSX by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data_Sheet_4_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Table_1_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.XLSX by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data_Sheet_3_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data_Sheet_6_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data_Sheet_1_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data_Sheet_2_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. In this work, we analyzed the genetic diversity and population structure of Russian local goats, including Altai Mountain, Altai White Downy, Dagestan Downy, Dagestan Local, Karachaev, Orenburg, and Soviet Mohair goats, which were genotyped with the Illumina Goat SNP50 BeadChip. …”

Data Sheet 1_Efficacy and safety of Tanshinone capsule in Acne vulgaris: a systematic review and meta-analysis.docx by Yutong Deng (20908982)

“…</p>Results<p>A total of 2,969 participants from 28 studies were included. We found that Tanshinone capsules can reduce acne recurrence rates [risk ratio (RR) 0.44, 95% confidence interval (CI): 0.34 to 0.57, p < 0.00001]; downregulate levels of necrosis factor-alpha (TNF-α) [ mean difference (MD) 0.44, −10.18, 95% CI: −13.57 to −8.04, p < 0.00001], interleukin (IL) 4 (MD -6.46, 95%CI: −7.14 to −5.77, p < 0.00001), IL-6 (MD -16.14, 95%CI: −30.10 to −2.18, p = 0.02), IL-8 (MD -4.48, 95%CI: −8.30 to −0.65, p = 0.02) and testosterone (MD -14.50, 95%CI: −17.59 to −11.40, p < 0.00001); lower Global Acne Grading System (GAGS) score (MD -4.71, 95%CI: −7.62 to −1.80, p = 0.002); decrease sebum secretion rates (MD -0.29, 95%CI: −0.49 to −0.10, p = 0.003), but the regulation of Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Estradiol (E₂) is not obvious. …”

Supplementary Material for: Systematic Review and Meta-Analysis of the Impact of Hypoxia on Infarcted Myocardium: Better or Worse? by Pang B. (5404793)

“…Overall, chronic hypoxia was found to have a beneficial effect on the ejection fraction (standard mean difference [SMD] = 5.39; 95% confidence interval [CI], 3.83 to 6.95; <i>P</i> < 0.001) of the infarcted heart, whereas acute hypoxia significantly improved hemodynamics, as indicated by an increase in the maximal rate of rise of left ventricular pressure (SMD = 1.27; 95% CI, 0.27 to 2.28; <i>P</i> = 0.013) and cardiac output (SMD = 1.26; 95% CI, 0.34 to 2.18; <i>P</i> = 0.007) and a decrease in total systematic vascular resistance (SMD = –0.89; 95% CI, –1.24 to –0.53; <i>P</i> < 0.001). …”

FGF2 activates WNT/β-catenin signaling. by Pavel Krejci (167835)

“…<p>(A) RCS cells were transfected with Topflash firefly luciferase (F-Luc) and control <i>Renilla</i> luciferase (<i>R</i>-Luc) vectors, treated with FGF2 (ng/ml), WNT3a and WNT5a (40 ng/ml) and analyzed for luciferase activity 20 hours later. …”

Table_2_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Phelan Niamh (10342460)

“…There was no change in the median cycle length (28 days) or days of bleeding (5) but there was a wider variability of cycle length (p = 0.01) and a 1 day median decrease in the minimum (p < 0.0001) and maximum (p = 0.009) cycle length. …”

Table_1_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Phelan Niamh (10342460)

“…There was no change in the median cycle length (28 days) or days of bleeding (5) but there was a wider variability of cycle length (p = 0.01) and a 1 day median decrease in the minimum (p < 0.0001) and maximum (p = 0.009) cycle length. …”

DataSheet1_Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study.pdf by Mingming Pan (5576021)

“…Compared to the placebo, a significant decrease of the weekly mean Worst Itching Intensity Numerical Rating Scale was found in the HSK21542-0.30 μg/kg group (p = 0.046), but without significant improvement in the Skindex-16 score.…”

Trypsin inhibitors increase the amount of trypsin needed to potentiate fibrocyte potentiation. by Michael J. V. White (443102)

“…Compared to the no-trypsin control, there was a significant increase in the number of fibrocytes with p<.05 for 4 µl/ml inhibitor for 10,000 ng/ml and at 1 µl/ml inhibitor for 5,000 ng/ml, and p<.001 at 1 µl/ml inhibitor for 2,500 and 10,000 ng/ml and at 0.1 µl/ml inhibitor for 2500 and 5,000 ng/ml (1-way ANOVA, Dunnett’s test). …”

PDTC inhibits the <i>Nacrein</i> promoter activity. by Juan Sun (439334)

“…<p>Equal amounts of pGL3-<i>Nacrein</i> Luciferase and pcDNA4.0A/<i>Pf-IKK</i> plasmids were co-transfected into Hela cells that were 24 h previously treated with increasing concentrations of PDTC (0, 25 μM, 50 μM, 100 μM and 200 μM). 0.5 ng of Renilla was used as an internal reference. …”

CXCL12-induced migration via AKT is reduced by LPS treatment. by Hyo-Kyung Pak (727742)

“…<p>A) RPMI 8226 cells were stimulated with 100 ng/mL CXCL12 for 5 minutes in the presence or absence of 10 ng/mL LPS. …”