MUS81 causes DNA double-strand breaks upon Chk1 inhibition that result in cell death. by Josep V. Forment (119177)

“…Neutral comet assays were performed on cells transfected with siLuc or siMus81 #2 and then treated with 200 nM AZD7762 or 500 nM CEP-3891 for 5 h, or transfected with siChk1 as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023517#pone-0023517-g001" target="_blank">Fig. 1D</a>. …”

Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis by Hirokazu Honda (2964768)

“…Twenty patients who were injected with either CERA (N = 10) or DA (N = 10) at the end of the dialysis week (day 0), who had ferritin ≥ 100 ng/mL and/or transferrin saturation ≥ 20%, and hemoglobin > 9 g/dL were selected from among the 59 patients. …”

Application of Circulating Tumor DNA as a Non-Invasive Tool for Monitoring the Progression of Colorectal Cancer by Jiaolin Zhou (3147249)

“…The tumor loads appeared a sudden decrease upon surgery or other adjuvant treatments and then generally maintained at low levels (0.092ng/mL) until disease recurred. ctDNA increased by 13-fold when disease relapsed in one patient while the CEA and CA 19–9 levels remained normal. …”

Figure S4 from Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies by Rodrigo A. Toledo (14996709)

Time since the Population Collapse by Benoît Goossens (5103)

“…The thin and thick lines correspond to S1 and S2, respectively. The prior is shown as a dashed line, its median being 100,000 y ago (see text). …”

Reduction in TB incidence and mortality achievable from shorter-course regimens over time. by Mariam O. Fofana (562254)

“…<p>Assuming TB incidence of 125 per 100,000/year, and 7% overall treatment default, the implementation of a four-month regimen vs. a six-month regimen results in a 1.9% reduction in incidence at 10 years (vertical line marks year 10 after introduction of a new regimen). …”

Biomass-diversity relationship. by Andrea S. Downing (131132)

“…The total biomass made up by 100 species decreases with increasing interspecific competition strength (left hand panel). …”

Capillary density. by Yeong-Hoon Choi (286493)

“…<p>A) Representative micrographs of left ventricular cross-sections (6 µm thickness) showing capillary vessels in all groups (as visualized by FITC-labeled lectin, scale bar represents 100 µm). …”

Effects of PP on the proliferation of liver cancer cell lines. by Wenwen Xu (175846)

“…<p><b>A.</b> MTT assay was taken to evaluate the liver cancer cell (Huh7, Hep3B, HepG2 and SMMC-7721) viability after the treatment with different concentrations of PP (0, 25, 50, 100, 200 or 400 µg/ml respectively) for up to 96 hr. …”

Bufalin exerted potent anti-osteosarcoma activity <i>in vitro</i>. by Xian-biao Xie (302694)

“…<p>(A) Bufalin induced a dose- and time-dependent decrease in osteosarcoma cell growth. …”

Supplementary Table 1 - Additional PSD Results by David Aguilar (7148330)

“…Summary of Additional Power Spectral Density Differences during Recovery Sleep. </b>Arrows represent a significant increase (↑) or decrease (↓) in normalized mGluR5 KO spectral power compared to WT controls in the same condition. …”

Immunohistochemistry of Adult OC1 Knockout Retinas. by Jillian J. Goetz (644028)

“…However, anti-Calb28k-staining shows a decrease in horizontal cells in OC1-KO retinas as compared to a wildtype littermate (F,F'). …”

Knockdown of IGFBP7 restored the TGF-β1-induced EMT in HRPTECs. by Jun Watanabe (403029)

“…HRPTECs were transfected with control or IGFBP7 siRNAs (25 nM final concentrations) and subsequently stimulated with TGF-β1 (2.5 ng/ml, 48 h). Lowering the expressions of IGFBP7 proteins reduced the TGF-β1-induced α-SMA expression, but failed to restore the TGF-β1-decreased E-cadherin expression. …”

DataSheet1_Using anti-Müllerian hormone to predict premature ovarian insufficiency: a retrospective cross-sectional study.docx by Yuanxin Huang (20286858)

“…At AMH level below 0.5ng/ml,basal FSH increased significantly with age. …”

Antiprotease activity of HE-4 at different concentration and at different condition against various serine, cystine and aspartic proteases. by Nirmal Chhikara (124762)

“…<p>(<b>A</b>) Percentage inhibition of various proteases like: trypsin, chymottrypsin, PSA, proteinase K, pepsin and papain by HE-4. …”

PDE1 inhibition reduces palmitate-induced apoptosis and stimulates CREB phosphorylation in INS-1 cells. by Evan P. S. Pratt (7305542)

“…B) The PDE1 inhibitor 8MM-IBMX (100 μM) and pan PDE inhibitor IBMX (100 μM) significantly decrease the level of caspase-3/7 activation induced by palmitate toxicity (**, P < 0.01, *, P < 0.05 compared to palmitate; One-way ANOVA, Tukey post-hoc test). …”

Synergy between GPER1 and n-3 PUFAs in increasing MCF-7 cell cAMP-PKA signaling. by WenQing Cao (107805)

“…The mean of gray value was measured as described in B (see bottom of blot), which indicated the PKA activity (n = 2). <b>E</b>, a PKA inhibitor, KT5720 (100 nM), reduced the inhibitory effect of E2 on n-3 PUFA-treated T47D cell colony formation (n = 2). …”

Table1_Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.XLSX by Jiping Li (469560)

“…In vitro, BV-2 cells were treated with LPS (100 ng/ml) before adding different doses of EDA. …”

Doxycycline-induced expression of MTG16 in Raji/MTG16 Tet-On 3G cells. by Parveen Kumar (428921)

“…Cells were incubated without (no DOX, blue) or with 20 ng/ml doxycycline (DOX, red) at 2×10⁵/ml up to 72 h and cell cycle analyses were performed by flow cytometry at intervals indicated. …”

HDAC inhibitors affect tissue-specific promoters differently. by Angelika Danielsson (229695)

“…Cells were then incubated with 3 ng/ml FK228 or 5 mM VPA for 48 h. Both FK228 and VPA enhanced the transgene expression of the Ad[CgA-LUC] vector in BON cells about 10 times although the increase was not significant. …”