Hippocampalsynaptophysin in prion-diseased and normal brain homogenate-inoculated animals. by Kathryn J. Hilton (426924)

“…<p>Sy38 labelling of the presynaptic marker synaptophysin in a) NBH, b) ME7, c) 79A, and d) 22L at 13 weeks post-inoculation. e) The laminar structure of the hippocampus of an NBH animal: there is particularly dense synaptophysin labelling in the stratum oriens and <i>radiatum</i> in CA1 and CA3 and at the border between the granule cells and the molecular layer of the dentate gyrus. f) There is a significant decrease in the ratio of synaptic density in the stratum radiatum versus the synaptic density in the stratum lacunosum for all three prion strains when compared to NBH animals. ** <i>P</i> < 0.01, by Bonferroni <i>post hoc</i> test after a significant one-way ANOVA (n=3-4 sections from each of 3 animals per treatment group). …”

The inhibition of mitochondrial respiratory chain complex activity by longer chain TPP⁺ compounds is dose dependent. by Jan Trnka (441288)

“…<b>D.</b> A low concentration of decylTPP (100 <i>μ</i>M) appears to cause a slight ‘activation’ of complex IV activity, while higher concentrations caused inhibition. …”

Percentage of invasion of <i>B. pseudomallei</i> NCTC 10274 in presence and absence of mAbs. by Bhavani V. Peddayelachagiri (532923)

“…However, BURK24 and BURK37 inhibited the invasion of bacteria into A549 cells, resulting in a drastic decrease in percentage invasion to 0.41 and 0.32 respectively. …”

Effect of exercise and PCB on levels of MCP-1 in wound tissue at day 3 and day 5 post-wounding. by Mahesh R. Pillai (9292269)

“…<p>On Day 3, not exercised animals demonstrate a pattern of increased MCP-1 concentrations with PCB administration as compared to no PCB administration, except PCB 500 which reveals a decrease. …”

Extracellular nutrient dependences of <i>in vitro</i> cancer cell lines. by Iñigo Apaolaza (6628892)

“…The more negative CERES scores are, the more cellular proliferation will be decreased; <b>d)</b> Expression levels of the most limiting gene in the ngMCSs associated with Myo-Inositol in 45 auxotrophic and 45 prototrophic cell lines. …”

The RBPJ AOS variants show dysregulated Notch target gene expression when compared to WT RBPJ. by Ellen K. Gagliani (11478756)

“…Cells were additionally transfected with increasing concentrations (50, 150 & 250 ng) of either WT, NBM (F261A/V263A/R422E/E425R/E398R), KRS (K195E/R218H/S221D), NBM/KRS, or K195E Rbpj constructs in panels <b><i>ii-iv</i></b>. …”

Cyclic M₂(RL)₂ Coordination Complexes of 5-(3-[<i>N</i>-<i>tert</i>-Butyl-<i>N</i>-aminoxyl]phenyl)pyrimidine with Paramagnetic Transition Metal Dications by Martha Baskett (1821274)

“…Cu₂(hfac)₄(RL)₂ shows more complex behavior, with no high-temperature plateau in χ<i>T</i>(<i>T</i>) up to 300 K but a monotonic decrease down to about 100 K. The Cu(II)−nitroxide bonds decrease by 0.2−0.3 Å over the same temperature range, corresponding to a change of nitroxide coordination from axial to equatorial. …”

Cyclic M₂(RL)₂ Coordination Complexes of 5-(3-[<i>N</i>-<i>tert</i>-Butyl-<i>N</i>-aminoxyl]phenyl)pyrimidine with Paramagnetic Transition Metal Dications by Martha Baskett (1821274)

“…Cu₂(hfac)₄(RL)₂ shows more complex behavior, with no high-temperature plateau in χ<i>T</i>(<i>T</i>) up to 300 K but a monotonic decrease down to about 100 K. The Cu(II)−nitroxide bonds decrease by 0.2−0.3 Å over the same temperature range, corresponding to a change of nitroxide coordination from axial to equatorial. …”

Cyclic M₂(RL)₂ Coordination Complexes of 5-(3-[<i>N</i>-<i>tert</i>-Butyl-<i>N</i>-aminoxyl]phenyl)pyrimidine with Paramagnetic Transition Metal Dications by Martha Baskett (1821274)

“…Cu₂(hfac)₄(RL)₂ shows more complex behavior, with no high-temperature plateau in χ<i>T</i>(<i>T</i>) up to 300 K but a monotonic decrease down to about 100 K. The Cu(II)−nitroxide bonds decrease by 0.2−0.3 Å over the same temperature range, corresponding to a change of nitroxide coordination from axial to equatorial. …”

Cyclic M₂(RL)₂ Coordination Complexes of 5-(3-[<i>N</i>-<i>tert</i>-Butyl-<i>N</i>-aminoxyl]phenyl)pyrimidine with Paramagnetic Transition Metal Dications by Martha Baskett (1821274)

“…Cu₂(hfac)₄(RL)₂ shows more complex behavior, with no high-temperature plateau in χ<i>T</i>(<i>T</i>) up to 300 K but a monotonic decrease down to about 100 K. The Cu(II)−nitroxide bonds decrease by 0.2−0.3 Å over the same temperature range, corresponding to a change of nitroxide coordination from axial to equatorial. …”

Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight J... by Keith D. Rochfort (592433)

“…</p><p>Results</p><p>In response to treatment with either TNF-α or IL-6 (0–100 ng/ml, 0–24 hrs), our studies consistently demonstrated significant dose- and time-dependent decreases in the expression of all interendothelial junction proteins examined, in parallel with dose- and time-dependent increases in ROS generation and HBMvEC permeability. …”

Image_1_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Table_3_Global burden of lower respiratory infections during the last three decades.DOC by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Image_5_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Presentation_2_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Image_11_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Image_14_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Image_9_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Table_2_Global burden of lower respiratory infections during the last three decades.DOC by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”

Image_8_Global burden of lower respiratory infections during the last three decades.PDF by Saeid Safiri (3713035)

“…The global age-standardized incidence and death rates for LRIs were 6,295 (5,887.4–6,737.3) and 34.3 (31.1–37.9) per 100,000 in 2019, which represents a 23.9% (22.5–25.4) and 48.5% (42.9–54.0) decrease, respectively since 1990. …”