Data_Sheet_1_Health Effects of Metabolic Risks in the United States From 1990 to 2019.docx by Ruifang Chen (2451214)

“…</p>Results<p>In 2019, the age-standardized death and DALY rates attributable to metabolic risks were 174.9 and 4738.7 per 100,000 people, accounting for 33.1% and 18.2% of death and DALY rates from all causes in the US, and there was a decrease by −32.5% and −21.2% in age-standardized death and DALY rates since 1990. …”

Is Obstructive Sleep Apnea Associated with Cardiovascular and All-Cause Mortality? by Xiahui Ge (437665)

“…<div><p>Background</p><p>Studies have reported inconsistent findings regarding the association between obstructive sleep apnea (OSA) and future risks of cardiovascular and all-cause mortality. We conducted a meta-analysis to investigate whether OSA is an independent predictor for future cardiovascular and all-cause mortality using prospective observational studies.…”

Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice by Albert Nguyen (2580886)

“…Of these genes, only <i>Gpx1</i> exhibited changes in DNA methylation associated with dyslipidemia and exercise: we observed both increased DNA methylation with dyslipidemia and a transient decrease in DNA methylation with exercise. …”

CaMKII selective peptide inhibitors reduces myocardial fibrosis in SHRs. by Ersilia Cipolletta (760356)

“…SHR treated with AntCaNtide and tat-CN17β showed a decrease of interstitial fibrosis and reduced cardiomyocytes size when compared to SHR untreated group. …”

Synthetic Multivalent Antifungal Peptides Effective against Fungi by Rajamani Lakshminarayanan (321411)

“…Replacing the first arginine led to a 2–4 fold decrease in antifungal activities and reduced membrane disruption properties. …”

TRα2 shows dominant negative activity on positively and negatively regulated T₃ target genes <i>in vivo</i>. by Hajer Guissouma (586934)

“…</b><i>ME-tk-luc</i> transcription was measured in hypothyroid (PTU) 2 days old mice treated with T₃ (2.5 µg/g b.w.) (PTU+T3) or saline (PTU), 18 h after hypothalamic injection of 1 µg reporter construct and 100 ng expression vector (empty pSG5 (Ct) or pSG5-TRα1 (TRα1) or pSG5-TRα2 (TRα2)). …”

30 Hz stimulation does not permit recovery from previous ensemble recall. by Casey M. Baker (16033144)

“…<p>(A) We categorized the 8 stimulations for each stimulation period as either odd or even stimulations. …”

Effect of Hyperglycemia on eNOS function in EPCs by Elshiekh, Duaa Ibnomer

“…Cells were treated with normal glucose (NG, 5.5mM) and high glucose (HG, 25mM) media for 3 & 6 days, and the effect on eNOS and Akt phosphorylation were assessed using western blot. …”
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(a) Time-dependent activation (Tyr701 phosphorylation) of signal transducer and activator of transcription 1 (STAT1) by interferon-γ (IFN-γ) in J774 macrophages by Outi Sareila (66176)

“…</p><p></p> Cells were treated with IFN-γ (5 ng/mL) for different times as indicated. Proteins were extracted with modified RIPA-buffer, and the protein contents were measured. …”

Rspo3 inhibits the zygotic Wnt/β-catenin signaling in zebrafish embryos. by Xiaozhi Rong (576365)

“…(<b>E</b>) Rspo3 inhibited Wnt3a activity. Representative views of embryos. The pictures were taken at the 5-somite stage. …”

Data_Sheet_1_The Sensitivity of Subsurface Microbes to Ocean Warming Accentuates Future Declines in Particulate Carbon Export.pdf by Emma Louise Cavan (6178583)

“…In line with observations from polar regions and the deep ocean we imposed an elevated temperature sensitivity (E_a = 1.0 eV) to cooler regions; firstly to the Southern Ocean (south of 40°S) and secondly where temperature at 100 m depth <13°C. …”

Supplementary Material for: Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa by Ponikowska M. (8280024)

“…<b><i>Results:</i></b> Compared with controls, patients with HS demonstrated a deranged iron status as evidenced by decreased levels of ferritin (91 ± 87 vs. 157 ± 99 µg/L), Tsat (21.5 ± 10.8 vs. 42.2 ± 11.7%) and hepcidin (31.3 ± 25.9 vs. 44.2 ± 22.0 ng/mL) (all <i>p</i> < 0.05 vs. controls). …”

IL6/STAT3 modulates estrogen-induced GREB1 transcriptional activity in breast cancer cells. by Mingli Liu (304361)

“…To determine the best efficient concentration for IL-6, hormone-starved MCF-7 cells were treated with various concentrations of IL-6 (0∼100 ng/ml) for 24 h. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046410#pone-0046410-g005" target="_blank">Figure 5E</a> shows that the maximum reduction of E2-mediated GREB1 activity is seen at 10 ng/ml, the inhibitory effects are decreased regardless of whether the doses are further increased or decreased throughout the experiment. …”

Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants by Sharath P. Sasi (541865)

“…Compared to 3 control groups, p75KD/LLC+TNF showed >2-5-fold decreases in tV (p<0.001) and tW (p<0.0001). …”

Role of voice therapy in adherence to voice rest (King et al., 2021) by Renee E. King (11409101)

“…</div><div><b>Results:</b> Talking decreased postprocedure by 63% in the therapy group and 65% in the counseling group, both significantly more than the 35% decrease measured in the evaluation group. …”

Mechanisms involved in the regulation of CD36 expression by tumor necrosis factor (TNF)α by Jean Frédéric Boyer (32017)

“…Human monocytes were incubated with macrophage-serum-free medium (M-SFM) alone (control), or with M-SFM containing TNFα (10 ng/ml) for 5, 30 or 60 minutes, and then stimulated, or not, with a synthetic ligand of PPARγ, rosiglitazone (R; 5 μmol/l) for 45 minutes. …”

Bcl11b protein level is down-regulated in the presence of HDAC inhibitors. by Samira Chandwani (474607)

“…N = 3–5; +/− SEM (*p<0.05, **p<0.01, ***p<0.001).</p>…”

Influence of DMF and MMF on NO production of LPS stimulated microglia. by Darius Moharregh-Khiabani (212285)

“…<p>After stimulation for 24 h with 10 ng/ml LPS a dose dependent decrease of NO production in cells incubated with DMF (5, 10, 50µM/ml) could be observed. …”

Antigen-specific response is defective in lupus-prone mice. by Linda A. Lieberman (152611)

“…<p>Splenocytes were collected from infected mice 7 dpi and were stimulated 3 days in vitro with either IL-12 (5ng/ml), STAg (20 ug/ml), or IL-12+ STAg. Supernatants were assayed by ELISA for IFN-gamma production. …”

Search results of kinetic parameter space and prediction of MdmX effect. by Sohyoung Kim (253617)

“…</p>c<p>The presence of MdmX (upto 100 fold k15) decreased maximum value (peak of oscillations) by >30%.…”