DataSheet4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Effect of glutamate (Glut) and 4-AP on CAPs in <i>ex vivo</i> spinal ventral columns. by Yan Fu (110146)

“…<p>(A) Histogram showing an irreversible increase in mean peak CAP amplitudes (normalized to 100% of the CAP amplitude (Pre) prior to glutamate treatment) after 1 mM glutamate treatment. …”

Sections of testis from 6 month old male medaka stained with H&E. by Hilary D. Miller (29470)

“…F: Animal exposed to 10.0 µg/L EE2 for 14 days has a severe thickening of the interstitium, increased vacuolization, and an overall decrease in germinal epithelium. …”

Replacement of chicken skin with canola oil in chicken nuggets by Sandra Tiemi Seó (16453032)

“…There was a decrease in AI (T0%-raw vs. T100%-fried, 0.39 vs. 0.10) and IT (T0%-raw vs. …”

EDA2 down-regulates activated EGFR and reduces cell viability. by Laura E. Hanold (705810)

“…<p>(a) Cells were stimulated with 50 ng/mL EGF for 5 min in the presence or absence of EDA peptides, followed by western blotting. …”

AA and DHA modulate phosphorylation of ERK1/2 in both FXR1-WT and KO macrophages. by Claude Lachance (201669)

“…<p>FXR1-WT (A and C) and FXR1-KO (B and D) macrophage cell lines (1×10⁶ cells) were untreated (Medium) or treated with AA (100 nM) or DHA (100 nM) for 21 h. …”

Overexpression of virally down-regulated genes impairs WNV infectivity. by Tonya M. Colpitts (177569)

“…Infection is indicated as ng WNV E/ng actin. p<.001 for all 3 genes vs. control, one way ANOVA and Kruskal-Wallis test were used, n = 10. …”

TGF-β1 down-regulates the expression of CD300a and Eomes in Th1 cells. by Sriram Narayanan (364941)

“…(D) Sorted naïve CD4 T cells were polarized under Th1 conditions in the absence or presence of 5 ng/ml of TGF-β1. At day 12, cells were stimulated with plate bound anti-CD3 + anti-CD28 mAb overnight, followed by RNA extraction. …”

SufT is essential for <i>in vitro</i> growth and regulates survival under redox stress and inside macrophages. by Ashutosh Tripathi (2827796)

“…<p>(A) A gradual decrease in the growth of the SufT-KD strain with increasing concentration of ATc (0–200 ng/mL) in standard liquid 7H9 medium. …”

The <i>Citrobacter rodentium</i> type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses by Cedric N. Berger (4544008)

“…<i>rodentium</i>. This overlapped with a decrease in STAT3 phosphorylation in IECs. Importantly, while the reduced CCH and abundance of antimicrobial proteins during Δ<i>espO</i> infection did not affect <i>C</i>. …”

Effects of fadrozole on prolactin-positive cells in the pituitary of male rats. by María José García Barrado (590761)

“…PD: pars distalis of pituitary gland. Scale bar: 100 µm. b) Irregular and strongly stained prolactin-positive cells (arrows) in untreated male rats. c) Polygonal and weakly stained prolactin-positive cells (arrows) after 5 doses of fadrozole. …”

Image1_High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon.TIF by Julia Schoenfeld (11136603)

“…</p><p>Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82–2.79 ng/mL; 1132–1388 pg/mL; 9.24–56.65 ng/mL; 6–27 ng/L; p < 0.001) and returned to baseline within 24–72 h. …”

EGF enhances cyclin G2 degradation. by Stefanie Bernaudo (4167634)

“…E) OV2008 cells were transfected with either full-length cyclin G2-V5 or PEST deletion mutants (PEST-24 or ΔPEST) and treated with EGF for 30 min before addition of CHX for another 2 hours. …”

EFFECT OF WATER DEFICIT AND ABSCISIC ACID ON PHOTOSYNTHETIC AND ANTIOXIDANT METABOLISM IN SEEDLINGS OF Calophyllum brasiliense (CAMBESS.) by Lucas Coutinho Reis (6511265)

“…The decrease in stomatal conductance was accompanied by a decrease in photosynthetic and transpiration rates, but seedlings treated with 10 µM ABA presented a higher photosynthetic rate than the remaining treatments under water deficit. …”

Muscle fiber CSAs of the soleus and EDL muscles in the GH-administered SDRs treated with dexamethasone, BCAA or both. by Hikaru Nishida (757003)

“…Dex-treated group. D. Dex elicited a decrease in the CSAs of the EDL muscles in the GH-treated SDRs. …”

Disease progression phenotypes, clinical cohorts, and our computational framework together with the reproducibility of disease progression pattern. by Kimiyo N. Yamamoto (213724)

“…For validations of PDAC progression at the terminal stage, we utilized data of 369 patients who had all necessary information: (a) the final scan within two months before death; (b) the date of death; and (c) type and duration of CTx. …”