PDBu (1 µM) increases the amplitude of outward K⁺ currents. by Sébastien Hayoz (5656207)

“…<p>Panel A: K⁺ currents elicited by linear voltage ramps varying from −100 to 100 mV. …”

Acute reduction of Ezh2 induces apoptosis in NSCs. by Falak Sher (151989)

“…Immunostaining of dissociated neurospheres in proliferation medium shows a decrease in proliferation and increase in cell death after using Ezh2-shRNA compared to the control (nc-shRNA). …”

Intracellular GSH and GSH/GSSG ratio in monolayer cultures upon induced oxidative stress. by Mireille M. J. P. E. Sthijns (12245491)

“…<p>A) Exposing the monolayer cultures of 0:100, 50:50 and 100:0 INS1E:alphaTC1 cells to 500 μM H₂O₂ only induced a significant decrease in intracellular GSH compared to a monolayer culture not exposed to H₂O₂ in the ratios of 50:50 and 0:100 INS1E:alphaTC1. …”

Combined treatments of GTPs and SFN sensitize ERα-negative breast cancer cells for tamoxifen therapy. by Syed M. Meeran (321543)

“…For a comparison, DNMTs inhibitor, AZC (2.5 µM), and HDAC inhibitor, TSA (100 ng), also administrated to MDA-MB-231 cells. …”

SETD2 mediates the binding of MALAT1 and pSmads. by Jinqiang Zhang (709289)

“…<b>B,</b> RNA immunoprecipitation of MALAT1 by using anti-Smad2/3 or anti-SETD2 antibodies in Hep3B cells (with siSETD2 or siControl transfection) treated with 5ng/mL TGF-β1 or vehicle for 2 hours. The precipitated MALAT1 was assessed by qRT-PCR. …”

Confirmation of Functionality of Constructs and Model System Used by Maarten F Bijlsma (380371)

“…</p> <p>(C) Shh concentration in medium is below the detection limit (5 ng/ml) of Western blotting. Medium was spiked with decreasing concentrations of recombinant Shh, and blotted along with a 4× concentrated medium sample obtained from C3H/10T1/2 fibroblasts (incubated for 16 h at a volume-to-surface ratio identical to the mix-and-match and medium transfer experiments).…”

(A) Schematic presentation of the human AID protein sequence along with the positions of the lysine residues mutated in the various constructs by Said Aoufouchi (49316)

“…(D) Stable BL2 clones expressing the indicated AID-EGFP lysine mutants, WT-AID-EGFP, or mutNLS-AID-EGFP were incubated with cycloheximide (CHX, 50 μg/ml) and LMB (10 ng/ml). The decay of the protein was followed by the decrease in fluorescence intensity. …”

Concentration dependent reduction of IL-6 and CXCL8 by BET inhibitors. by Younis M. Khan (554747)

“…These parameters were used to assess cell viability following treatment with JQ1 (0.5 µM) and PFI-1 (1 µM) for 16 hours. DMSO/Control (<1%) alone, PFI-1, JQ1(-) or JQ1 resulted in only 5% decrease of overall cell viability. …”

Long-term trends of potential years of life lost due to main causes of death in the Slovak population, 2004-2013 by Martin Samohyl (10388448)

“…The PYLL rate is age-standardized and expressed as a sum of all deaths per 100,000. In the period 2004-2013, the highest mean PYLL rates were observed in neoplasms in the whole population (2,103 per 100,000), as well as in females (2,088 per 100,000), with a permanent high significant increase of AAPC of PYLL in both genders. …”

The time-dependent currents in <i>Mytilus galloprovincialis</i> hemocytes are modulated by the osmotic pressure. by Monica Bregante (3391766)

“…D) The hyperosmotic bath solution determines a decrease of the steady-state current elicited by V = -100 mV (left bar) without altering the capacitance of the cells (right bar). …”

Supplementary Material for: Early Variation of Respiratory Indexes to Predict Death or ICU Admission in Severe Acute Respiratory Syndrome Coronavirus-2-Related Respiratory Failure by Maraziti G. (12243848)

“…<b><i>Results:</i></b> ROX <3.85 at admission (hazard ratio [HR] 2.95, 95% confidence interval [CI] 1.29–6.77) and decreasing RI or P/F during hospitalization (RI: HR 1.05, 95% CI: 1.00–1.09; P/F: HR 1.01, 95% CI: 1.00–1.02) were predictors of in-hospital death. …”

Marimastat reversed hepatic steatosis in diet-induced obese mice as well as in <i>ob/ob</i> animals, as demonstrated by histology and magnetic resonance spectroscopy. by Vincent E. de Meijer (343377)

“…Histological findings were confirmed with MRS, demonstrating a decrease in fat content in Marimastat-treated animals (A,B bottom panels).…”

Abrogation of TGF-β1-induced growth inhibition by PGE2. by Erina Takai (465811)

“…Treatment with TGF-β1 decreased the ratio of S phase cells. (B-D) Twenty-four hours after incubation with or without TGF-β1 (5 ng/mL), cells were supplemented with PGE2 (10, 25 µM) and further incubated for 2 days. …”

Metformin reduces lipid stores and causes intestinal fluid imbalance. by Cathy Slack (251729)

“…<p>(<b>A</b>) Quantitation of triacylglycerides (TAGs) in flies treated with 0 mM, 1 mM, 10 mM and 100 mM metformin for 7 days. …”

DZNep-mediated sensitization to TRAIL correlates with enhanced activation of caspase signaling and involvement of the mitochondrial apoptosis pathway. by Frank K. Braun (698401)

“…(<b>C</b>) Activation of the mitochondrial apoptosis pathway was determined by TMRM staining for mitochondrial membrane potential (Δψ_m) in Z-138 cells treated with DZNep (0.2, 1, 3, or 5 μM) alone for 40 h. (<b>D, E</b>) Analysis of Δψ_m of cells (Z-138, BJAB, and SU-DHL-9) treated with DZNep (1 μM, 24 h) followed by TRAIL (10 ng/ml for 1–5 h or 20 ng/ml for 16 h). …”

αII-Spectrin silencing changes invadosome morphologies. by Aurélie Ponceau (716023)

“…Knockdown of αII-spectrin induces a significant decrease in ring diameters due in particular to an increase in the percentage of rings with a small size and a decrease number of large rings. …”

Immunohistochemical examination of MPO in liver tissue. by Rasha E. Mostafa (11767721)

“…<p>Liver tissues, immunohistochemically stained with anti-MPO antibodies, from <b>(A)</b> sham-operated rats, <b>(B)</b> ovariectomy-control rats didn’t show notable expression of NF-KB in the liver tissue, <b>(C, D)</b> TAA-control rats showing a robust positive result of the stain all over the lobule, <b>(E)</b> rats treated with <i>panax ginseng</i> (100 mg/kg) showing a mild decrease in the positively stained cells, and <b>(F)</b> rats treated with <i>panax ginseng</i> (300 mg/kg) showing a remarkable decrease in the positive result <b>(MPO immunohistochemical staining)</b>.…”

Micromolar ZnCl₂ reduces the amplitude of the time-dependent current. by Monica Bregante (3391766)

“…<p>A) The decrease of a typical inward time-dependent current induced by the addition of 100 μM ZnCl₂ to the bath solution. …”

Density of opportunities for recombination initiation along the chromosome. by Thibault Corneloup (16293971)

“…Given the low divergence between strains, when we average the number of these opportunities for recombination per kb across bins of 100kb for each of the tree recipients (REL606, HS and 536), we see that focusing on the 700kb before and after <i>galK</i> locus there are several hundred of opportunities for recombination per kb. …”

Cellular blebbing induced by NK1R activation is not blocked by the PLC inhibitor U73122. by John Meshki (36999)

“…<p>(<b>A</b>) Representative intracellular calcium recordings of U373MG cells preincubated with <i>(left)</i> control or <i>(right)</i> U73122 (10 µM) for 60 min and then stimulated with SP (100 nM) where indicated by <i>solid arrow</i>. …”