Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

KS1 and KS2 combined RNA-seq experiment differentially expressed genes: <i>Kmt2d</i>^<i>-/-</i> vs <i>Kmt2d</i>^<i>+/+</i>, Day 7. by Christine W. Gao (18794576)

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

Impact of age on sharing of top 5000 TCRβ clones. by Sarah A. Johnson (11355817)

Serum cholesterol concentrations in hyperthyroid cats and euthyroid controls. by Molly A. Bechtold (18794251)

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Inhibition of FleA by 2EHex or fucose results in a loss of mucin binding and greatly reduced phagocytosis by macrophages. by Sheena C. Kerr (495450)

“…<p>(A) Structures of fucopyranoside compounds. (B) Amount of compound required to inhibit binding of labeled FleA to mucin by 50% (IC50 [μM]). …”

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)

(A, B) Western blot analysis of lysates from the two clones with the TrkB-BAC minigene (77−5 and 77−6) before and after deglycosylation and probed with an antibody recognizing TrkB... by Francesco Tomassoni-Ardori (22216521)

ROC analysis for differentiating bladder cancer patients from controls using the ucfDNA concentration before and after normalization by creatinine concentration in those samples wi... by Meihui Chen (1670020)

Parallel testing of (a) cell vitality with MTT- and (b) membrane disruption with the LDH-assay at different time points (2 min, 15 min, 30 min, 2 h, 4 h, 24 h) and concentrations (... by Lars Steinstraesser (20161)

“…<p>The membrane integrity of the cells after incubation with [D]-K₃H₃L₉ at the LD₅₀ in 2 and 4 multiples showed a parabolic curve progression with over hundred percent LDH release after 24 h. …”

Effect of NaCl on the oligomeric mass/size of <i>M</i>. <i>leprae</i> HSP18. by Sandip Kumar Nandi (713237)

Predicting a Stable Dimeric Form of the PD1-PDL1 Complex: Implications for Understanding the PD1 Activation Mechanism by Luis F. Ponce (2795155)

ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency by Philippe Joly (3161052)

“…Finally, these findings support a larger scale screening for HERPUD1 R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.…”

Initial placements distributions, conditional on field. by Sergey V. Popov (6719075)

Attenuation of CDK expression and cyclin D-CDK4/6 activity by androgen in PC3-Lenti-AR. by Young-Chae Kim (163381)

“…(G) CDK4 and CDK6 proteins were reduced 50% or more at 24 hours and 65% or more at 48 hours, and phosphorylated CDK2 as well as total CDK2 protein decreased 50% with androgen treatment at 48 hours. …”

SYBR Green I-Background suppressor gametocytocidal assay. by Natalie G. Sanders (621904)