Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

On a steepening environmental gradient, a sharp and stable range margin forms near the expansion threshold. by Jitka Polechová (5400749)

“…(<b>b</b>) As the environmental gradient steepens, the frequency of limited adaptation within the metapopulation increases (black and grey), and hence neutral variation decreases (blue). The black line gives the proportion of demes with limited adaptation after 50,000 generations, when the range margin appears stable; grey gives the proportion after 40,000 generations (depicted is an average over a sliding window of 15 demes). …”

DataSheet_1_A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage.zip by Hong-Ji Deng (11182902)

“…<p>Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). …”

Course of T_body of a female pup before, during and after a thunderstorm. by Nicola Erdsack (443390)

“…</b>: The thunderstorm stopped but it still rained on. <b>5:50 p.m.</b>: T_air = 19.7°C. T_body had decreased by 0.7°C to 36.9°C. …”

Importance of the features. by Zhi Jiang (269212)

Variable selection in the RF algorithm. by Zhi Jiang (269212)

Maternal kidney changes due to STZ administration and pregnancy. by Narumi Takahashi (5343218)

Dynamic binding of patient serum antibody isotypes over short to medium term for moderate and mild COVID-19 disease. by Marie Le Berre (6299012)

Healthy control group HR and CBF changes. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

List of abbreviations used in this paper. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

Estimation of the CO and CBF. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

Two food choices profiles at Time 1 and Time 2. by Juan Cao (3145449)

“…</p><p>Method</p><p>Two-wave longitudinal data was collected from a sample of 431 Chinese college students (Mean baseline age = 19.15 ± 0.61 years; 45.7% male). …”

GSTM3 A/B Polymorphism and Risk for Head and Neck Cancer: A Meta-Analysis by Yu Xu (52257)

“…Stratification by tumor site indicated that the GSTM3 polymorphism was associated with a decreased risk of laryngeal cancer under recessive model and homozygote comparison (OR = 0.52, 95%CI: 0.30–0.89; and OR = 0.50, 95%CI: 0.29–0.87, respectively); By stratifying source of control, decreased cancer risk was observed in hospital-based population under all genetic models (OR = 0.67, 95%CI: 0.56–0.81 for the dominant model; OR = 0.66, 95%CI: 0.46–0.95 for the recessive model; OR = 0.55, 95%CI: 0.37–0.83 for the homozygote comparison model, and OR = 0.70, 95%CI: 0.58–0.84 for the heterozygote comparison model).…”

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing <i>Iso</i>combretastatins and Phenstatins as Antitumor Agents by Yanqing Pang (4386715)

“…Most of these selenium containing hybrids exhibited potent cytotoxicity against a panel of cancel cell lines, with IC₅₀ values in the submicromolar concentration range. …”

<i>PsnWRKY95</i> transgenic plants selection and functional analysis of <i>PsnWRKY95</i> in cadmium resistance. by Yuzhao Ma (12840632)

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro by Brita Singers Sørensen (783581)

“…A dramatic decrease in ATP turnover (SiHa) and protein synthesis (both cell lines) was observed when hypoxia and low pH_e were combined.…”

CA alleviated DOX-induced myocardial injury <i>in vitro</i> and <i>in vivo</i>. by Meijiao Mao (10677555)

Table_1_Is a Higher Protein-Lower Glycemic Index Diet More Nutritious Than a Conventional Diet? A PREVIEW Sub-study.pdf by Alice Meroni (9737102)

“…term=NCT01777893&draw=2&rank=1) who were randomly assigned to a HPLG diet (25% energy from protein, dietary GI ≤ 50, n = 85) or a MPMG diet (15% energy from protein, dietary GI ≥ 56, n = 76). …”

Baseline characteristics of study subjects. by Arlete Gianfaldoni (17655603)

“…To detect LH and FSH pulses, the technique proposed by Santen and Bardin was adopted; therefore, one pulse was defined as a 20% increase in the concentrations as to the preceding point, followed by an important decrease.…”