DataSheet3_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

DataSheet4_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

The overall negative effects played by IFITM3 during viral spread are the result of two concomitant antiviral mechanisms, acting in the protection of target cells as well as in the... by Kevin Tartour (514249)

Syndecan-1 is expressed along the basolateral surface of the venular endothelium. by Paulina M. Kowalewska (625078)

RNAi-based screen for genes that modify aSyn oligomerization in living cells. by Susana A. Gonçalves (199613)

“…Genes modifying aSyn oligomerization by at least 50% (2) were identified using fluorescence microscopy analysis and considered for further validation. …”

Image1_Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized a... by Vanessa B. Candido (14670266)

Image2_Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized a... by Vanessa B. Candido (14670266)

The effect of isoalantolactone on the cell cycle in UM-SCC-10A cells. by Minjun Wu (464934)

“…The representative histograms are from UM-SCC-10A cells incubated with different concentration of isoalantolactone (25 and 50 µM) or caspase inhibitor (Z-VAD-FMK50 µM). …”

Human glaucomatous trabecular cells produce SDF-1(5-67). by Alexandre Denoyer (160189)

“…MMP inhibitors batimastat (100 nM) and TIMP-1 (0.5 nM) induce a decrease in SDF-1(5-67) production, whereas TNF-α (50 ng/mL [2.9 nM]) and TGF-β2 (10 ng/mL [0.8 nM]) enhance the production of SDF-1(5-67). ** <i>P</i><0.01. …”

mPEG PV1-Fab’ dampens IFN-γ production by CD4⁺ T lymphocytes. by Pedro Henrique Papotto (791904)

Self-reported change in diet, physical activity and medication taking compared to pre-COVID-19 in relation to trajectories of HbA1c in people with diabetes (N = 4,925). by Martin Gillies Banke Rasmussen (10227291)

Influence of TTR in A-Beta aggregates. by Rita Costa (51920)

Vascular and parenchymal inflammation are key components of cerebral malaria in <i>P</i>. <i>berghei</i> ANKA-infected mice and are decreased in α_D ^-/- mice. by Isaclaudia G. de Azevedo-Quintanilha (8173734)

Proteomic analysis of wild type and <i>trm5-1</i>. by Qianqian Guo (339283)

SIRT5 proviral activity is independent of the MAVS signaling pathway. by Marius Walter (13775591)

“…</b> Hypotheses for the role of the SIRT5/Nsp14 interaction during SARS-CoV-2 infection. …”

<i>Cyclocarya paliurus</i> extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion by Hisae Yoshitomi (722082)

“…Moreover, we found that oral administration of CPE (1 g/kg) to streptozotocin-induced hyperglycemic mice produced a progressive decrease in plasma glucose levels at 1 h after single dosing. …”

Data Sheet 1_Secretoneurin plasma levels are decreased after catheter ablation for atrial fibrillation—patients with AF produce lower SN levels than healthy individuals: the SAFE r... by Jiří Plášek (21805048)

“…Background<p>Secretoneurin (SN) is a neuropeptide that counterbalances disorders of cell calcium cycling via calmodulin and thus may be involved in arrhythmogenesis. …”

Supplementary Material for: Decreasing Trend in Incidence of Late Onset Culture Positive Bloodstream Infections but Not Late Onset Meningitis in Preterm Infants <33 Weeks Gestation... by Zhou Q. (4138852)

“…Compared to infants with no IVH grade 3 or above, infants with IVH grade 3, or above had higher odds of late onset meningitis versus no infection (AOR 4.16; 95% CI 3.17, 5.44), and higher odds of late onset meningitis versus late onset CPBSI (AOR 4.11; 95% CI 3.08, 5.50). <b><i>Conclusions:</i></b> There was a decreasing trend of late onset CPBSI but not late onset meningitis. …”

Northern blot analysis of total RNA extracted from primary cultures of SECs and MNPs at day 1 after isolation either untreated (c) or treated with IFN-γ 10000 (10)U/ml (I) or IFN-γ... by Katrin Neubauer (48437)

Image_2_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…</p>Discussion<p>These findings demonstrate that 50% reduction in SIRT1 is sufficient to induce the hallmarks of skeletal aging namely, decreased cortical thickness and increased porosity in female mice, highlighting the role of SIRT1 as a regulator of cortical bone quantity and quality. …”