Simvastatin alters actin organization, cell morphology, and Rac1 activity in endothelial monolayers. by Marsha C. Lampi (845609)

“…Cell circularity, where a perfectly circular cell has a value of 1, decreases with increasing simvastatin concentration (n = 3, 50–54 cells per condition). …”

Classification of inactive compounds. by MohammedBashar Al-Qazzan (22439236)

“…</p><p>Results</p><p>Glyoxalase I inhibition revealed that 4-hydroxy-estradiol exhibited the highest efficacy with an IC₅₀ value of 0.226 µM. Trichostatin A demonstrated a significant anti-proliferation effect in colorectal cancer cells (CACO2, HCT116, SW620, HT29) with IC₅₀ values ranging from 14.0 µM to 27.0 µM. …”

I.p. injection of LPS induces inflammation in the brain A. by Fionä Caratis (12759506)

ODE model fit is average of many DS simulations. by Apeksha Singh (8174256)

Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…Notably, among these derivatives, compound <b>15</b> showed improved anti-HAdV activity (IC₅₀ = 0.27 μM), significantly decreased cytotoxicity (CC₅₀ = 156.8 μM), and low <i>in vivo</i> toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further <i>in vivo</i> efficacy studies for the treatment of HAdV infections.…”

IFA treatment facilitated host immune clearance of hypervirulent <i>K</i>. <i>pneumoniae</i> by targeting capsule. by Tingting Wang (123983)

Effect of thalidomide on CUL5 and NEDD8 localization in control and si-transfected HUVEC at 24 hours after treatment. by Bryan Kunkler (5204327)

Genetic characterization of <i>Mycoplasma pneumoniae</i> isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of <i>p1</i> gene ty... by Chihiro Katsukawa (6264050)

“…However, in 2015 and after, the detection rate of MRMP decreased significantly and did not exceed 50%. Genotyping of the <i>p1</i> gene of these isolates showed that most of MRMP strains harbored type 1 <i>p1</i> gene. …”

PDS5B is mutated in a case of familial CdLS. by Bin Zhang (64682)

“…The father, two affected children, and one unaffected child carry the R1292Q mutation (depicted by blackened symbol or small black dot). (E) The PDS5B(R1292Q) mutant has decreased DNA binding. EMSA using the T5-8-T5 AT-rich probe showed decreased DNA binding by mutant PDS5B compared to wildtype PDS5B. …”

Referenced studies with functional connectivity correlations with intensity and/or duration of chronic pain. by Peter A. Pahapill (8468607)

IFA effectively limited bacterial dissemination and protected mice from lethal hypervirulent <i>K</i>. <i>pneumoniae</i> pneumonia. by Tingting Wang (123983)

LTP modulates steady-state inactivation of A-type K⁺ currents. by Sung-Cherl Jung (261358)

“…Scale bars, 200 pA, 50 ms. The A-current available for activation at −60 mV was significantly decreased only in the neurons receiving paired stimulation 10 min after conditioning stimulation (a red arrow). …”

Binding of PregOBP56a to <i>N</i>-phenyl-1-naphthylamine (1-NPN) and potential ligands derived from chicken meat. by Yuko Ishida (104789)

“…Due to low binding to PregOBP56a, the IC₅₀ of other test competitors was not obtained.…”

TEC functional assays after hypoxia or Tac. by Vincenzo Cantaluppi (92814)

Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors - Fi... by Vincenzo Cantaluppi (92814)

Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation by Shahin Ahmadi (9334861)

“…The outliers and promoters of increase/decrease of logEC₅₀ are extracted and the mechanistic interpretation of effective descriptors for the model is also offered.Highlights</p><p>Global SMILES-based QSAR model was developed to predict the toxicity of ILs.…”

DataSheet1_CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.docx by Chao Fang (456315)

“…In particular, individuals with the GG genotype had a 4-fold higher risk of heart rate abnormality than carriers of the T allele (OR = 4.32, 95% CI: 1.96–9.50, p = 0.00027).…”

Alteration in overall structure and the helicity of the peptide binding domain (PBD). by Koushik Roy (193484)

Conceptualization of changes in <i>STM</i>_<i>FCS</i> and pain levels seen in ESCRPS FBSS patients. by Peter A. Pahapill (8468607)

CUL5 protein localization in HUVEC treated with increasing doses of thalidomide. by Bryan Kunkler (5204327)