BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells by Ana Rita Thomazela Machado (6047777)

“…BjussuLAAO-II increased the methylation of CCND1 and decreased the methylation of CDKN1A in monoculture and GADD45A in both cell-culture models (p < 0.05). …”

Influence of nuclear proteins on the kinetics of unfolding of the h <i>c-myc</i> GQ structure, assayed by measuring the decrease in FRET activities in the presence of the complemen... by Anna Fekete (144891)

“…</p><p>F-<i>myc</i> GQ-R double labeled FRET oligonucleotide (25 pmol) was incubated either alone or with the tested proteins for one minute in a volume of 50 µl, than its FRET spectra was taken (0 min value). …”

Morphine decrease co-localization between BrdU-DCX labeled immature neurons, while increase co-localization between BrdU-GFAP labeled glia. by Yue Zhang (30585)

A PRISMA flowchart illustrated the selection of studies included in our systematic review. by Chenyi Ye (2697208)

Effect of control or Notch3 ASOs administered subcutaneously to C57BL/6 wild type mice on <i>Notch3</i> mRNA. by Ernesto Canalis (516050)

Fig 2 - by Ernesto Canalis (516050)

Effect of control or Notch3 ASOs on <i>Notch3</i> mRNA expression and cell replication in calvarial osteoblast-enriched cells. by Ernesto Canalis (516050)

Representative experimental samples. by Weisheng Zhao (3746023)

“…Based on the mechanical test results, reducing humidity can decrease the loss of uniaxial compressive strength (UCS) caused by moisture absorption from approximately 50% to 15.48%. …”

Mechanical testing apparatus and samples. by Weisheng Zhao (3746023)

“…Based on the mechanical test results, reducing humidity can decrease the loss of uniaxial compressive strength (UCS) caused by moisture absorption from approximately 50% to 15.48%. …”

Relationship between UCS, E, and water content. by Weisheng Zhao (3746023)

“…Based on the mechanical test results, reducing humidity can decrease the loss of uniaxial compressive strength (UCS) caused by moisture absorption from approximately 50% to 15.48%. …”

Hygroscopic experimental device. by Weisheng Zhao (3746023)

“…Based on the mechanical test results, reducing humidity can decrease the loss of uniaxial compressive strength (UCS) caused by moisture absorption from approximately 50% to 15.48%. …”

The mean relative error and standard deviation (vertical bar) versus the number of receive channels for acceleration factors of 2 and 3, showing that the error increases as the num... by Kamlesh Pawar (425523)

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: <i>In vitro</i>, kinetic, and <i>in silico</i> studies... by Sumaira Javaid (7886897)

Variations in the prevalence of episiotomy in France between 2010 and 2021 according to the classification for episiotomy practices. by Raphaele Houlbracq (20558509)

Placenta-Enriched LincRNAs <i>MIR503HG</i> and <i>LINC00629</i> Decrease Migration and Invasion Potential of JEG-3 Cell Line by Bruna Rodrigues Muys (2588305)

“…Further analysis, using a cancer cell lines panel, showed that <i>MIR503HG and LINC00629</i> were expressed in 50% and 100% of the cancer cell lines, respectively. …”

Depletion of CD25⁺ cells decreased the percentage of IL-17 and IFN-γ CD4⁺ Th cells in the LRN of infected mice. by Adam N. Odeh (3170022)

HbA1c, BMI and Lipid levels of study participants (n = 382). by Habiba I. Ali (10451382)

PGRP-LC in the gut promotes ageing by <i>A</i>. <i>persici</i>. by Taro Onuma (15195377)

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”