Metformin requires transcription factor SKN-1 to increase median lifespan, via a mechanism that acts in both ASI neurons and the intestine. by Brian Onken (86790)

“…In fact, metformin has significantly detrimental effects in <i>skn-1(zu135)</i> mutants that express <i>skn-1::gfp</i> only in the ASI neurons (mean lifespan for these animals raised on 0 mM or 50 mM metformin is 18 and 13 days, respectively, and the surivival curve with metformin treatment is shifted significantly to the left, <i>P</i><0.0001 by the Log-rank test). …”

NHR-80 can function in the absence of <i>daf-16</i> but requires <i>daf-12</i>. by Jérôme Goudeau (228021)

“…(E) Finally, <i>nhr-80</i> overexpression increases the lifespan of <i>glp-1(e2141ts);daf-9(rh50)</i> double mutants (MLS of 15 and 10 d for <i>glp-1(e2141ts);daf-9(rh50)</i> mutants carrying the transgene or not, respectively; <i>p</i><0.0001, 50% extension in mean lifespan). …”

Complementary conditioning measures across the clinical study groups. by Gabriela Ribeiro (4748373)

“…<p>Across conditioning for CS^- and CS⁺ flavors, ratings did not vary according to stimulus or group for <b>(A) Hunger</b> (Stimulus: F_{(1, 50} = 0.003, <i>P</i> = 0.96; Group: F_{(2, 50)} = 2.2, <i>P</i> = 0.1; Interaction: F_{(2, 50)} = 0.1, <i>P</i> = 0.7); <b>(B) Thirst</b> (Stimulus: F_{(1, 50)} = 0.01, <i>P</i> = 0.9; Group: F_{(2, 50)} = 1.5, <i>P</i> = 0.22; Interaction: F _{(2, 50)} = 0.96, <i>P</i> = 0.4) and <b>(C) Novelty</b> (Stimulus: F_{(1, 50)} = 1.6, <i>P</i> = 0.2; Group: F_{(2, 50)} = 1.8, <i>P</i> = 0.17; Interaction: F_{(2, 50)} = 0.5, <i>P</i> = 0.6). …”

Variability in performance and response to task dynamics. by Daniel Ramandi (10047543)

PMV knockdown or overexpression modulates sensitivity to WEHI-916. by Brad E. Sleebs (591301)

“…(E) Dose-response curves of <i>P. falciparum</i> expressing PMVHA-<i>glmS</i> shows parasites have enhanced sensitivity to 916 following PMV knockdown (3.3-fold decrease in EC₅₀). Parasitemia was determined 72 h after addition of 916 to ring parasites with or without PMV knockdown (knockdown ring parasites were obtained by adding 6 mM GlcN to trophozoites for 24 h). …”

Local reward learning and GRS-based learning became more pronounced over the course of adolescence. by Marco K. Wittmann (14710470)

Comparison of RPA2 dynamics in WT, <i>Cdk2</i>^<i>T160A</i>, <i>and Cdk2</i>^{<i>−/−</i>} spermatocytes. by Nathan Palmer (264897)

“…Error bars are indicative of the mean and SD. All data were assumed to be non-normally distributed. …”

Extracellular lactate and glucose levels in the hippocampus, measured before, during, and after behavioral testing. by Lori A. Newman (337628)

“…Lactate concentrations significantly increased at the beginning of behavioral testing (n = 4; t₃ = 4.77, p<0.02; MEAN ± SEM: 112.50%±3.15%). In contrast, glucose concentrations decreased after 5 minutes on the task (n = 3; t₂ = 3.58, p<0.05; MEAN ± SEM: 86.19%±7.73%). …”

Ccr7 is required for proper AP and DV embryo patterning. by Shu-Yu Wu (129447)

“…<p>(A) The spectrum of dorsalized phenotypes in embryos injected with MO1-<i>ccr7</i> at 27 hpf, ranging from highly dorsalized (C4–5; b) with truncated tails and trunks to C3 with tail deficiencies (b′) (total <i>n</i> = 190, seven independent experiments for 12 ng MO1-<i>ccr7</i> and <i>n</i> = 35, one experiment for 20 ng MO1-<i>ccr7</i>). …”

Image_2_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.pdf by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Table_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.xlsx by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Image_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.pdf by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Supplementary Material for: The Effect of The Oral Iron Chelator Deferiprone on Iron Overload and Oxidative Stress in Patients with Myelodysplastic Syndromes A Study by the Israeli... by Merkel D. (17648583)

Cerebral Hemodynamics in Patients with Hemolytic Uremic Syndrome Assessed by Susceptibility Weighted Imaging and Four-Dimensional Non-Contrast MR Angiography by Ulrike Löbel (3325251)

“…TTP ranged from 3.7 to 10.2 frames (mean, 7.9 ± 1.4). Hemoglobin at the time of MRI (n = 35) was decreased in all patients (range, 5.0 to 12.6 g/dL; mean, 8.2 ± 1.4); hematocrit (n = 33) was abnormally low in all but a single patient (range, 14.3 to 37.2%; mean, 23.7 ± 4.2). …”

Biomarkers in CSF and blood. by Marianne Ullestad Huun (5608088)

Injection of either <i>miR-3906-</i>MO or <i>homer-1b</i> mRNA affects fast muscle differentiation by regulating the calcium concentration in muscle cells. by Cheng-Yung Lin (403166)

“…<p>(<b>A–C</b>) Wild-type (WT) zebrafish embryos at 24 hpf and embryos injected with (<b>D–F</b>) <i>miR-3906</i> dsR (1.5 ng), (<b>G–I</b>) <i>miR-3906</i>-MO (8 ng), (<b>J–L</b>) <i>homer-1b</i> mRNA (400 pg), and (<b>M–O</b>) <i>homer-1b</i>-MO (3 ng) were collected, and the expressions of fast muscle type <i>fmhc4</i>, slow muscle type <i>smhc1</i>, and calcium-sensitive gene <i>atp2a1</i> were detected by WISH. …”

Surface markers analysis of EMSCs after IFN-γ treatment and during increased serial passages. by Chun-Chun Cheng (324809)

“…<p>(A) MHC I and MHC II expression profiles for EMSCs (passage five) were analysed under 10 ng or (B) 100 ng IFN-γ treatment. …”

The effect of stress on sound processing increases with repeated exposure. by Ghattas Bisharat (20706928)

“…While it increased for SST cells (2-way ANOVA, condition S1 F = 44, <i>p</i> = 3.7 × 10⁻¹¹, nested ANOVA (mouse nested within session) F = 31.1, <i>p</i> = 2.5 × 10⁻⁰⁸, S3 F = 61.2, <i>p</i> = 6.6 × 10⁻¹⁵, nested ANOVA (mouse nested within session) F = 56.6, <i>p</i> = 6.4 × 10⁻¹⁴, and S5 F = 159, <i>p</i> = 9.6 × 10⁻³⁶, nested ANOVA (mouse nested within session) F = 129.2, <i>p</i> = 1.8 × 10⁻²⁹). Values represent mean ± SE. (b) Change in activity per tracked cell in response to a 50 dB noise is defined as the slope of a linear fit of the mean activity of the baseline days and activity on days 1, 3, and 5 of stress (examples of the linear fit on the right). …”

HOXA2 control of target enhancers. by Laure Bridoux (481118)

“…The total HOX dose is unvaried and corresponds to 100%; HOXA2 and HOXA3 are translated alone and co-translated with each other at different ratios, as follows: 100% HOXA2; 75% HOXA2 + 25% HOXA3; 50% HOXA2 + 50% HOXA3; 25% HOXA2 + 75% HOXA3; 100% HOXA3. …”

Learning differently modulated sensory responses of RS and FS neurons in wM1 and wM2 areas. by Vahid Esmaeili (12700352)

“…Top: baseline-subtracted (50 ms prior to whisker onset) population firing rate (mean ± SEM) overlaid for Novice mice (147 neurons in 7 mice) and Expert mice (452 neurons in 11 mice). …”