Flow chart for the enrolled patients. by Kyu Jin Lee (18143946)

“…Left ventricular (LV) function was categorized as either normal LV ejection fraction (LVEF ≥ 50%) or decreased LVEF (<50%).</p><p>Results</p><p>Among the 1,194 patients with septic shock, 392 (32.8%) who underwent echocardiography within 24 h of time zero were included in the final analysis (normal LVEF: n = 246; decreased LVEF: n = 146). …”

A 27-year-old female with an acute cardioembolic infarction fifteen hours after the onset. by Daichi Momosaka (6160418)

“…<b>G:</b> MTR_asym spectra show decreased MTR_asym(3.5ppm) or APTW signal (%) in the infarct area compared to the CNAWM. mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; FLAIR, fluid attenuated inversion recovery; DWI, diffusion-weighted imaging; ROI, region-of-interest; ADC, apparent diffusion coefficient; APTW, amide proton transfer-weighted; CEST, chemical exchange saturation transfer; CNAWM, contralateral normal-appearing white matter; S_sat(ppm) and S₀, the signal intensities obtained with and without selective radiofrequency saturation pulse irradiation, respectively; APT₁₀, APT₂₅, APT₅₀, APT₇₅, and APT₉₀, correspond to the 10th, 25th, 50th, 75th, and 90th percentiles of APTW signal value, respectively.…”

Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository by Fidéline Bonnet-Serrano (4782546)

“…The β- and α-cell masses were calculated in the 66 patients and the 50 controls for which the pancreas weight was available. …”

Elimination of the MRC rescues the prophase I delay due to constitutive Rad51 activation, while decreasing spore viability and increasing MI nondisjunction. by Andrew Ziesel (9422868)

Effect of inhibitory antibodies and human serum on NA enzymatic function ELLA and NA Star. by Harrison Powell (9040128)

Local sensitivity analysis of procoagulants, fibrin, F1.2 flux, and TAT flux. by Jason Chen (15937)

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Schematic of the reduced model. by Jason Chen (15937)

Illustration of the difference between the IC50 value assessed directly from experimental data and model-based deconvolution of mechanisms explaining downstream inhibition. by Jennifer L. Wilson (6061124)

“…In the proposed modeling framework, it is possible to separate effects on a specific cell type, from propagated effects, such as loss of upstream progenitors. …”

Cell cycle accumulation at G2/M in MTDH knockdown Hec50co cells at 24 hours after LBH589 or LBH589 and TRAIL treatment. by Xiangbing Meng (200278)

“…<p>(A) Cell cycle profiles were determined in control or MTDH knockdown Hec50co cells at 24 hours after treatment with 20 nM LBH589, 25 ng/ml TRAIL, or LBH589 and TRAIL in combination. …”

The potency of the blockage of FXIa varies over the subsets of fibrin concentration. by Jason Chen (15937)

Local sensitivity analysis of total thrombin, free, and bound thrombin in the clot. by Jason Chen (15937)

Total, free, and bound thrombin of 10,000 simulations of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

Plasma protein levels and thrombin binding sites distribution of the subsets of top and bottom 2% of fibrin concentration of 10,000 simulations. by Jason Chen (15937)

Fibrin concentration of 10,000 simulations compared to experimental data of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

H-MSCs^WT prevent hypoxia induced cardiac fibroblast activation, but leptin deficit inhibit this effect. by Panpan Chen (307628)

H-MSCs^WT reverses hypoxia stimulated collagen production and cardiac fibroblast differentiation into myofibroblasts. by Panpan Chen (307628)

The dental arch length at three timepoints: (A) at the patient’s birth, (B) at cheiloplasty, and (C) at palatoplasty. by Miki Kashiwagi (21439684)

RNA sequencing linkage analysis identifies a single base pair change on Chromosome 25 that is tightly linked to the <i>escapist</i> hypersensitive phenotype. by Elelbin A. Ortiz (8655285)