Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

A mechanism of non-target site resistance conferred by loss-of-function of <i>PAM16</i> is conserved in <i>M</i>. <i>polymorpha</i>. by Chloe Casey (14341756)

Effect of native (hOb) and Q90L obestatin (hObQ90L) on the ghrelin-induced (Ghr) decrease of evoked GABA synaptic responses in GHRH neurons. by Rim Hassouna (113060)

Response of the metabosensitive fibers to chemicals. by Guillaume Caron (816032)

“…Responses to LA were significantly decreased for the 1 mM concentration in all BoNT/A groups (B0: §, p<0.05; B50: §, p<0.05 and B100: §§§, p<0.001) compared to the respective concentration of the Control group. …”

Membrane-localized AR facilitates productive endocytosis and nuclear trafficking of KSHV. by Xing Wang (154377)

“…Cells were performed as mentioned above, except lacking of Triton X-100 treatment in non-permeabilized group. Scale bars represent 50 μm. (c) Knockdown of AR and EphA2 expression reduces KSHV endocytosis, as indicated by decreasing gB staining in cells. …”

LCR activity and background Ca at low and high SR Ca pumping rate Pup of 4 mM/s and 24 mM/s as membrane depolarizes from the MDP (Maximal Diastolic Potential) to -50 mV (a threshol... by Alexander V. Maltsev (4229458)

Heterogeneity of HASM membrane potential responses evoked by procontractile agonists co-treated with TAS2R agonists. by Blanca Camoretti-Mercado (762326)

4‑Aminoquinoline Antimalarials Containing a Benzyl­methyl­pyridyl­methyl­amine Group Are Active against Drug Resistant <i>Plasmodium falciparum</i> and Exhibit Oral Activity in Mic... by Mukesh C. Joshi (4670284)

“…These compounds exhibited significantly improved solubility and decreased lipophilicity and were potent against chloroquine-sensitive (NF54) and -resistant (Dd2 and 7G8) <i>P. falciparum</i> strains with 5/6 having IC₅₀ < 100 nM against the NF54 strain. …”

Flow chart describing samples. by Rabi Joël Gansaonré (20416803)

“…If a child’s growth changed from severe stunting to normal growth, their risk of repeating a grade decreased by 5.0 [95% CI: 0.0; 9.0] per 100 persons-years. …”

Primary data set used for analysis. by Louis Lambrechts (241741)

“…Here, we report on a field-based study in the city of Iquitos, Peru, where we conducted direct mosquito feedings on people naturally infected with DENV and that experienced mild illness. …”

Kinetics and dose response of distinct changes to HDMEC barriers induced by TNF and IL-β. by Paul R. Clark (714064)

“…B: TNF induction of an early TEER rise and a bi-phasic TEER decrease. Labels indicate the peak of the early TEER increase and two distinct phases of TEER decrease (as nadirs to phases 1 and 2). …”

Urolithin A treatment slows reproductive decline in wild type. by Vanessa Cota (13833956)

UV-irradiated M-phase cells show decreased MCM 2–7 loading and G1 arrest after release: HEK293 cells and U2OS cells. by Masayuki Morino (304956)

Wnt5a Regulates the Assembly of Human Adipose Derived Stromal Vascular Fraction-Derived Microvasculatures by Venkat M. Ramakrishnan (2559520)

“…Immunocytochemistry confirmed Wnt5a protein expression by hSVF. To see if Wnt5a alone could restore IWP2-induced EC network inhibition, recombinant human Wnt5a (0–150 ng/ml) was added to IWP2-treated cultures. …”

miR-200c regulates migration associated genes such as filamin A. by Bojan Ljepoja (4921255)

“…<p>(a) A proteomic analysis of a TALENs knock-out (KO) of miR-200c in MCF7 cells revealed a set of proteins with differential expression, of which 50% are involved in migratory processes and are shown in the table. …”

<i>miR26a</i> controls vSMC differentiation via <i>smad1</i>-mediated BMP signaling. by Charlene Watterston (6704078)

“…There is no significant decrease in <i>miR26a</i> knockdown embryos (two Way ANOVA, N = 3, <i>miR26a</i> MO n = 15, Wildtype n = 15, Unpaired t test, ****p< 0.0001 as compared to control, Error Bars = SEM. …”

Developmental changes in HDAC1 and colocalization with BLBP in the <i>Xenopus</i> tectum. by Yi Tao (178829)

NatB-inactivation decreased Drk levels through its N-terminal sequences, which was regulated by the N-end rule E3 ubiquitin ligase POE/UBR4. by Zhentao Sheng (107495)

The <i>P[syt^P-L]</i> mutation decreases the Ca²⁺ affinity of release and vesicular release probability, but the readily releasable pool is unchanged. by Mallory C. Shields (4474210)

“…<p>(A) Mean EJP amplitudes from <i>+/-;P[syt^WT]/+</i> (filled black circles) and <i>+/-;P[syt^P-L]/+</i> (filled red circles) larvae at Ca²⁺ levels ranging from 0.05 mM—5.0 mM. …”

Crystal structure of SmTPI and TsTPI showing their cysteine residues. by Pedro Jimenez-Sandoval (831603)