Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Semi-log plot of the total number of medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of i... by Marcel Ausloos (748325)

Semi-log plot of the number of Gold medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of im... by Marcel Ausloos (748325)

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

Relationship between drug effects on animations task performance and emotion recognition performance. by Bianca A. Schuster (18824561)

Items. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”

Survey feedback. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”

S2 Table - by Penny A. Rudd (10298691)

Explanatory power in short period samples. by Mihály Ormos (697939)

Molluscicidal activity and physiological toxicity of quaternary benzo[c]phenanthridine alkaloids (QBAs) from <i>Macleaya cordata</i> fruits on <i>Oncomelania hupensis</i> by Wenshan Ke (7490798)

“…We sought to identify a high-efficiency biogenic molluscicide against <i>Oncomelania</i> with low toxicity, to avoid chemical molluscicide contamination and toxicity in aquatic organisms. …”

Explanatory power of risk measures in bullish sample. by Mihály Ormos (697939)

Explanatory power of risk measures in bearish sample. by Mihály Ormos (697939)

Data_Sheet_5_Adipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells.PDF by Rebecca Hasseli (6819464)

“…</p><p>Methods: Primary ECs or human umbilical vein endothelial cell (HUVEC) and primary RASFs were stimulated with adiponectin (10 μg/mL), visfatin (100 ng/mL), and resistin (20 ng/mL) or treated with methotrexate (1.5 and 1,000 μM) and the glucocorticoids prednisolone (1 μM) and dexamethasone (1 μM), respectively. …”

Predicting power in short periods out of sample. by Mihály Ormos (697939)

Mst1 knockout skewed macrophage polarization toward a proinflammatory and profibrotic phenotype with concomitant down-regulation of CD36. by Jianyang Li (461703)

Climate complexity in the migratory cycle of <i>Ammodramus bairdii</i> by Alexander Peña-Peniche (5687786)

“…A continuous and alarming decrease of its populations has been observed over the last 50 years, and studying its seasonal distribution and associated climatic niches could help improve strategies for its conservation. …”

Explanatory power of risk measures in long term by diversification. by Mihály Ormos (697939)

Secondary attack rates among 1407 close contacts based on case-patient^a characteristics, their own characteristics, and exposure setting. by Joseph Walker (4341838)