Data Sheet 1_Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis... by Hiroyuki Koami (3878434)

“…</p>Results<p>Of 2,726 patients who met the inclusion criteria, logistic regression models demonstrated that decreased CH50 is a significant predictor of 180-day mortality (OR: 0.98-0.99). …”

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

“…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …”

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

“…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

A Minor (<50%) Signet-Ring Cell Component Associated with Poor Prognosis in Colorectal Cancer Patients: A 26-Year Retrospective Study in China by Yinuo Tan (705777)

“…<div><p>Background</p><p>We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.…”

The minimum inhibitory concentrations (µg/mL) and the minimum bactericidal concentrations (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives. by Jean Paul Dzoyem (6424445)

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Percentages of inhibition of biofilm formation and eradication of synthesized 1,2,3,5-tetrazine derivatives. by Jean Paul Dzoyem (6424445)

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Reactions’ sequences to compounds 4. by Jean Paul Dzoyem (6424445)

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Percentage of violacein production in <i>Chromobacterium violaceum</i> by the most active synthesized 1,2,3,5-tetrazine derivatives (4a, 4b and 4c). by Jean Paul Dzoyem (6424445)

Subjects:

Image_1_Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s Disease.TIF by Hui Li (32376)

The S75A mutation of LeishIF4E3 leads to a decrease in granule formation in response to PBS starvation and to a reduced interaction with LeishIF4G-4. by Rohit Shrivastava (6459608)

Anti-cancer stem cell activity of a sesquiterpene lactone isolated from <i>Ambrosia arborescens</i> and of a synthetic derivative by Wendy Soria Sotillo (4408105)

“…<div><p>New regimens are constantly being pursued in cancer treatment, especially in the context of treatment-resistant cancer stem cells (CSCs) that are assumed to be involved in cancer recurrence. Here, we investigated the anti-cancer activity of sesquiterpene lactones (SLs) isolated from <i>Ambrosia arborescens</i> and of synthetic derivatives in breast cancer cell lines, with a specific focus on activity against CSCs. …”

VANGL2 recruits NLRP3 to OPTN for selective autophagic degradation. by Huaji Jiang (16907514)

VANGL2 recruits MARCH8 to promote the K27-linked ubiquitination of NLRP3. by Huaji Jiang (16907514)

Self-organising map-based dynamic decision-making algorithm for heterogeneous wireless sensor network by Umesh M. Kulkarni (10098026)

Effect of SERINC5 antagonism on HIV-1 replication in PBMC cultures. by Dorota Kmiec (5646374)