Metformin requires transcription factor SKN-1 to increase median lifespan, via a mechanism that acts in both ASI neurons and the intestine. by Brian Onken (86790)

“…To confirm that 50 mM metformin can induce SKN-1::GFP nuclear accumulation in the absence of NaN₃, we performed these experiments with N2 <i>Is007[skn-1::gfp;rol-6dm]</i> animals raised from eggs on 0 mM and 50 mM metformin and observed in liquid M9 media. …”

Image_2_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.pdf by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Table_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.xlsx by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Image_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.pdf by Grace Liang (4398046)

“…In addition to improvement in blood pressure and cholesterol, patients who lost at least 5 pounds, expended at least 1,000 additional kcals/week, and/or achieved ≥0.5 MET increase in fitness had a significant reduction in plasminogen activator inhibitor-1 [9.07 ng/mL (95% CI: 2.78–15.35 ng/mL); P = 0.026], platelet derived growth factor beta [376.077 pg/mL (95% CI: 44.69–707.46 pg/mL); P = 0.026); and angiopoietin-1 [(1104.11 pg/mL (95% CI: 2.92–2205.30 pg/mL); P = 0.049)].…”

Effects of (a) AG-490 and (b) WHI-P154 on IFN-γ-induced nitric oxide (NO) generation in J774 macrophages by Outi Sareila (66176)

“…</p><p></p> After 24-hour incubation with IFN-γ (5 ng/mL), the supernatants were collected and nitrite was measured in the culture medium as an indicator of NO production by Griess reaction. …”

IL-1β treatment does not induce cell death. by Himakarnika Alluri (2735689)

“…<p>IL-1β (10 ng/mL; 2 hours) treatment had no effect on cell viability (n = 5). …”

gp120 activates IL-10 in a dose dependent manner unlike IL-6 and IL-6 induced STAT3 phosphorylation which get downregulated. by Roni Sarkar (390168)

“…The X-axis shows the combined dosage of Nef and gp120, where Nef dosage has been kept fixed at 100 ng/ml and the gp120 dosage has been varied from 0.5 µg/ml to 4.0 µg/ml. …”

Hypothetical scheme of the stress response in the brain. by Olena Babenko (186646)

VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1- and Galectin-3-Induced Angiogenesis by Nicky D'Haene (422477)

Reduced thermal hypersensitivity in S1P₁^−/−mice. by Norbert Mair (113808)

DataSheet_1_Irrigation with primary wastewater alters wood anatomy and composition in willow Salix miyabeana SX67.docx by Ahmed Jerbi (14708509)

“…The majority (86%) of vessels had diameters range groups [20-30[, [30-40[and [40-50[µm and contributed to > 75% of theoretical K_S, while the group class [50-60[µm (less than 10% of vessels) still accounted for > 20% of total K_S regardless irrigation treatments. …”

Supplementar material of the manuscript  The Effects of Lipoic Acid on Yolk Nutrient Utilization, Energy Metabolism, and Redox Balance over Time in <em>Artemia</em> sp.  by Juan Rafael Buitrago Ramírez (6244172)

“…ETS activity was positively regulated by the addition of LA, with the most significant effects at concentrations of 5.0 and 10.0 µM at 12 and 24 h. For ETS activity, treatments with LA presented the highest values at 24 h, a period when ROS production decreased significantly, for the treatment with 10.0 µM. …”

Isomeric Mono-, Di-, and Tri-Bromobenzo-1H-Triazoles as Inhibitors of Human Protein Kinase CK2α by Romualda Wąsik (119538)

“…<div><p>To further clarify the role of the individual bromine atoms of 4,5,6,7-tetrabromotriazole (TBBt), a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition (IC₅₀) of human CK2α by the two mono-, the four di-, and the two tri- bromobenzotriazoles relative to that of TBBt. …”

BIOMECHANICAL, COORDINATIVE, AND PHYSIOLOGICAL RESPONSES TO A TIME-TO-EXHAUSTION PROTOCOL AT TWO SUBMAXIMAL INTENSITIES IN SWIMMING by Marcos Franken (8184234)

Gene expression of <i>Iex-1</i> and <i>Vegf-A</i> by qRT-PCR in outflow vein of AVF seven days after adventitial delivery of hydrogel alone, hydrogel with nanoparticle PLGA without... by Akshaar Brahmbhatt (551498)

EhLPPG is internalized and requires processing or endosomal trafficking for activation of NKT cells. by Hannelore Lotter (284153)

“…(B) Treatment of APC with an inhibitor of endocytosis, bafilomycin A1 (10 nM, 30 min), led to a decrease in the IFN-γ production in NKT cells after stimulation with α-GalCer (4 µg/ml) and EhLPPG (10 µg), but not with PamCys (4 µg/ml) and LPS (1 ng/ml). …”

Effect of anisotropy. by Diarmuid J. Cahalane (233294)

Functional effects of a Cdk5 inhibitor and/or GSK-3β inhibitor on the survival of pINT-EGFP cells. by Wen-Ching Lee (141923)

“…Original magnification: ×20, Scale bar: 50 µm. (B) Caspase-3 activity detected by casp-3 BDP levels. …”

Q-PCR analysis of sense transcript levels in wildtype and mutant lines for the three loci shown in <b>figure 1</b>. by Elena Zubko (41792)

Ethanol challenge in resistant and sensitized mice is associated with striatal epigenetic-related genes regulation. by Béatrice Botia (129695)