Inhibition of CXCL8 reduces proliferation, viability and invasion (Experiments vs simulation results). by Junho Lee (220469)

“…<p>(A) Time course of cell proliferation shows a drastic decrease in the LS174T cell population with CXCL8 knockdown (shCXCL8; blue) compared to control (LS174T) in <i>in vivo</i> experiments [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008257#pcbi.1008257.ref100" target="_blank">100</a>]. …”

AS021 drives <i>lacZ</i> expression in early-born Satb2⁺ neurons. by Kensuke Tashiro (193459)

“…Similarly to the piriform cortex, AS021 drives specific <i>lacZ</i> expression in Satb2⁺ neurons (96.88±1.59% at E12.5, 97.26±1.47% at E13.5, 92.09±0.52% at E14.5 and 91,63±3,08% at E16.5). Graphs show mean ± SEM. Scale bars: 100 µm.</p>…”

Data_Sheet_1_Aerobic granular sludge for complex heavy metal-containing wastewater treatment: characterization, performance, and mechanisms analysis.docx by Chong Liu (450204)

“…Ultimately, addition of complex HM stimulated microorganisms to excrete massive phosphodiesterases (PDEs), leading to a pronounced decrease in cyclic diguanylate (c-di-GMP) levels, which subsequently suppressed EPS secretion due to the direct linkage between c-di-GMP and EPS. …”

Changes in orientation tuning width with different contrasts in mixed contrasts blocks. by Lionel G. Nowak (373941)

“…Relative to 100%, all distributions are shifted to the left, indicating decreased HWHH with decreased contrast. …”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…<p dir="ltr">Supplementary Figure: Identification of osimertinib as an inhibitor of the MYLK4–CDKAL1–SALL2 axis a (left): RT‒qPCR and immunoblotting of RD cells treated with 40 ng/mL epidermal growth factor (EGF) and 2.5 µM osimertinib for 24 h revealed that osimertinib inhibits SALL2 expression in a translation-dependent manner. …”

SS-RARP2 mediated dispersal of the <i>trans</i>-Golgi interferes with protein transport to the host cell surface. by Karin Aistleitner (278525)

“…Autoradiographs of surface-associated proteins and total cell lysates are shown in the left hand panel and demonstrate a substantial decrease in surface exposure of <i>de novo</i> synthesized proteins in <i>R</i>. …”

Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis by Feifei Cheng (8985345)

Knockouts of <i>gpr-3</i> lack cAMP signaling response to melatonin. by Cathryn S. D. Maienza (20629929)

“…<p>Difference in relative cAMP concentration between <i>gpr-3</i>^<i>+</i> (N380-1, n = 6), <i>gpr-3</i>^{<i>-</i> (}N380-2, n = 6), and <i>gna-1</i>^<i>-</i>(n = 6) strains after 10-minute treatment with 5ng/mL melatonin in sterile water. Untreated group was treated only with water. …”

Celastrol has an inhibitory effect on TNFα-induced NF-κB signaling in MDA-MB-231 cells. by Laura Mezzanotte (223692)

“…<p>(3.A) Graph representing the decrease in fold NF-κB induction in MDA-MB-231 cells using celastrol by the multicolor assay (* p value <0.05; ** p value <0.01). (3.B) Composite image of the unmixed spectrum of luciferases: green signals represent CBG99 emission, red signals represent PpyRE9 emission spectrum and blue signals represent ExtGluc expression in control cells (first column) and cells treated with TNFα in combination with increasing concentrations of celastrol (0.1–3 µM). (3.C) Left: graph reporting the relative band intensity of p65 protein from the nuclear extract of control sample and samples treated with TNFα (10 ng/ml) or TNFα + celastrol (0.1 µM; 0.5 µM and 1 µM). …”

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition - Fig 9 by Himakarnika Alluri (2735689)

“…Animals were divided into sham (n = 6), vehicle + sham (n = 6), vehicle + TBI (n = 5) and melatonin + TBI (n = 6). Data are expressed as ng/brain cortex ± SEM. ‘*’ indicates statistical significance. …”

TGF-β₁ dependent effects on AP activity by SB431542 are depending on time. by Sabrina Ehnert (359631)

“…<p>Primary human osteoblasts stimulated with 5 ng/ml hra TGF-β₁ in the presence or absence of 20 nM SB431542. …”

Phenotypes of ovary cultures treated with FST288. by Zhengpin Wang (147664)

“…<p>Ovaries at 17.5 dpc were cultured for 7 days without treatment (as a control) or with 500 ng/mL FST288. …”

Serum brain-derived neurotrophic factor reflects the lower inflammation, lipid level, and major adverse cardiac and cerebrovascular events risk in maintenance hemodialysis patients by Hui Du (639270)

“…Our study shows that BDNF was notably (more than two folds) decreased in MHD patients compared with that in HCs (median (interquartile range) value: 5.5 (3.1–9.4) vs. 13.2 (9.4–19.1) ng/mL). …”

Data Sheet 1_Thermodynamic integration in combined fuel and power plants producing low carbon hydrogen and power with CCUS.docx by Daniel Mullen (5681870)

“…A first of a kind techno economic analysis concludes that the improvements present in a CO₂ abated CFP plant results in a 15.1%–17.3% and 7.6%–8.0% decrease in capital and operational expenditure respectively for the CO₂ capture cases. …”

Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010) by Stephane Olindo (4976189)

“…Between 1996–2000 and 2011–2015 study periods, the HTLV-1 seroprevalence significantly decreased by 63%.</p><p>Conclusion</p><p>Martinique faces a sudden and rapid decline of HAM/TSP incidence from 2001 in comparison to 1986–2000 periods. …”

Peptide membrane interaction. by Mônica S. Freitas (357825)

“…<p>(A) Living Vero cells were incubated with wtEBO₁₆ at 25 (circles) or 37°C (square). …”

Supplementary Material for: Diagnostic value of sST2, VCAM-1 and adiponectin in patients with breast cancer to predict anti-tumor treatment-related cardiac events: A pilot study by Rosenkaimer S.L. (12968150)

Expression of specific MSN markers. by E. M. André (4911670)

“…(D) Striatal GAD67 -positive neuron number also decreased progressively with a 30% decrease at day 4, 45% at day 7 and 100% at day 30, compared to day 0 representing 100%. …”

The Impact of Varying the Target Population for HPV 16 Vaccination by Ruanne V Barnabas (16126)

“…Vaccination at age 20 y produced a 63% decrease and at age 25 y, a 41% decrease, in cancer incidence.…”

data_share by Qi Zhu (9428795)

“…In the present study, by calculating the electron bounce-averaged pitch angle diffusion coefficients with kappa plasma dispersion relations, we investigate the sensitivity of hiss-induced cyclotron-resonant electron scattering loss to the spectral index <i>κ</i> under a variety of superthermal plasma conditions. Our results demonstrate that, with increasing <i>κ</i>, the diffusion coefficients of ∼20 - 100 keV radiation belt electrons significantly decrease at lower pitch angles and increase at higher pitch angles. …”