Nicotine microperfusion impairs VOR gain adaptation. by Francesca Prestori (416977)

“…Based on the polarity of the waveform of Purkinje cell activity identified in each track, the location of the granule cell layer was determined, and a dye-labelled vehicle solution with or without 5–10 ng nicotine (n = 8 and n = 7, respectively) was injected. …”

Cytochrome C-oxidase and ATP-production. by Constanze Nossol (326870)

“…Furthermore, a significant decrease in the ATP-content was found in IPEC-J2 after the application of FCCP (p<0.001; IPEC-J2-FCCP: 3680 pmol/100 000 cells).…”

Supplementary file 1_Global burden and trends of adverse effects of medical treatment, 1990–2021: an analysis from the global burden of disease study 2021.docx by Keqing Zhang (326894)

“…By 2036, it is forecast that ASIR will decrease to 72.33 (19.40–125.27) per 100,000 persons-year, and ASDR will decrease to 40.98 (21.52–60.43) per 100,000 persons-year.…”

Image_8_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_1_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_6_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_7_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_3_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Influences of stocking density and dietary probiotic supplementation on growing Japanese quail performance by KHALID M. MAHROSE (6572441)

“…Increasing level of probiotic up to 0.04 g/kg led to a significant decrease in dressing percentage by about 2.7 % compared to the control. …”

Curation of heavy metal corpus validates assigned DRS. by Allan Peter Davis (121500)

“…There is a progressive decrease in the percentage of curated articles with DRS <100. …”

Resveratrol Represses CXCL12- and TGFβ-Mediated <i>EGR1</i> Gene Transcription. by Mehrnaz Gharaee-Kermani (118877)

“…<p>Primary prostate, N1 immortalized prostate, normal lung, or IPF lung fibroblasts were pre-treated for 2 hrs with ascending doses of Resveratrol, then treated with vehicle, 4ng/ml TGF<b>β</b> (A) or 100 pM CXCL12 (B). for 2 hrs. …”

Fluorescence intensity quantification of O4 and MBP and immunohistological assessment of oligodendrocyte markers. by Georgia Panagiotakos (76482)

“…At 6 months post radiation, a spike in O4 levels is followed by a significant decrease that persists until one year and thereafter. …”

Validation of complete model with trafficking and phosphorylation parameters. by Lindsay Wendel Clegg (754229)

“…Experimental data (black) taken from Mellberg et. al. 2006 [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004158#pcbi.1004158.ref060" target="_blank">60</a>]. TIME cells, [V] = 50 ng/mL, measurements taken at t = 5 min. …”

Tie-2 Knock-Down Inhibits MLC-p and Promotes Disrupted Endothelial Architecture, Replicating the Effects of Ang-2 by Samir M Parikh (72439)

“…<div><p>(A) HMVECs were stimulated with Ang-2 (100 ng/ml) in 2.5% FBS EBM-2 for the indicated times, and phospho-Tie-2 was detected by immunoprecipitation and Western blot (upper) as described in Methods. …”

The reduction of the expression of TGF-β₁ in the pes-ARKO prostate epithelium may cause the thin smooth muscle layer. by Yuanjie Niu (214916)

“…The expressions of smooth muscle α-actin (c and d) and calponin (e and f) were detected following the treatment of 1 to 5 days. g) The genes of MyoD, Myogenin, α-SMA and Calponin, which are involved in the maturation of smooth muscle cells, were investigated after 10 ng/ml TGF-β₁ treatment.…”

Localization of TcCPR4 protein in elytral cuticle from TcCPR27-deficient insects. by Mi Young Noh (360269)

“…<p>Ultra-thin sections (~90 nm) of pharate adults (5 d-old pupae) that had been injected with dsRNA for <i>TcCPR27</i>, <i>TcCPR4/27</i> (co-injection) or <i>TcVer</i> (100 ng per insect) in late instar larvae were incubated with anti-TcCPR4 antibody. …”

Synthetic peptide N-DEVGEANN-C successfully inhibited Nef from interacting with and there by restore the functions of endogenous wild type ASK1 activity. by Balawant Kumar (422136)

“…(<b>B</b>) Synthetic peptide N-DEVGEANN-C prevented HIV-1Nef from offering protection against TNF -α induced, endogenous wild type ASK1 mediated apoptosis as evaluated using Annexin-V/PI assay. (<b>C</b>) Endogenous wild type ASK1 activity was rendered active by synthetic peptide N-DEVGEANN-C even in presence of HIV-1Nef as indicated by markedly decreased inhibitory Ser⁹⁶⁷ phosphorylation of ASK1 with a corresponding increase in p54/46JNK1 activation profile as indicated by higher phospho-p54/46JNK1 levels in western blot analysis. …”

Effects of administration regimen on antitumor activity, TK activity and viral replication. by Daniel Abate-Daga (200715)

“…Group A received 4 doses of 2×10¹⁰ vp ICOVIR5-TK-L on days 0, 1, 7 and 8, and 6 ip doses of 100 mg/kg GCV on days 4, 5, 6, 11, 12 and 13. …”