Methylation-Associated Partial Down-Regulation of Mesothelin Causes Resistance to Anti-Mesothelin Immunotoxins in a Pancreatic Cancer Cell Line by Kevin Hollevoet (710450)

“…Bisulfite sequencing analysis found that the mesothelin promoter region was significantly more methylated in KLM-1-R (59 ± 3.6%) compared to KLM-1 (41 ± 4.8%), indicating hypermethylation as a mechanism of mesothelin downregulation. The DNA methyltransferase inhibitor 5-azacytidine restored original mesothelin surface expression to more than half in KLM-1-R and increased sensitivity to RG7787 (IC₅₀ = 722.4 ± 232.6 ng/ml), although cells remained significantly less sensitive compared to parental KLM-1 cells (IC₅₀ = 4.41 ± 0.38 ng/ml). …”

TET1 regulates the mRNA and protein expression of TNFα. by Fangfang Sun (2410654)

Supplemental Figure 9 from BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume by Nicholas Theodosakis (3466673)

Total number of identified bone proteins with differences in abundance in each comparison, by label-free semi-quantitative differential expression analysis. by Cláudia A. N. Kobayashi (673416)

Categorization of NIAMS grants, funding, and US Global Burden of Disease DALY metrics (arranged in order of decreasing US DALY). by Chante Karimkhani (594512)

ST2+ KLRG-1+ Tregs from <i>T</i>. <i>cruzi</i> infected mice exhibit a phenotype compatible with <i>bona fide</i> trTregs. by Santiago Boccardo (5927954)

AMPK depletion is associated with decreased association of OGT with proteasome and increased 26S proteasome assembly and activity in AMPK-KO mice. by Jian Xu (31545)

Knock down of <i>edin</i> in the fat body decreases the encapsulation and killing ability of <i>Drosophila</i> larvae. by Leena-Maija Vanha-aho (323292)

“…Data are pooled from three to sixteen independent experiments, as indicated on each column, and at least 50 infected larvae were scored per experiment. Error bars in A and B show standard deviations. …”

THP1 TET1 knockout cell line was generated using CRISPR/Cas9. by Fangfang Sun (2410654)

Dose-dependence and time-dependence of peptides that showed partial decreases (left panels) and increases (right panels) in response to bortezomib. by Julia S. Gelman (104378)

“…Peptides that partially decreased (ratio 0.2 to 0.8, n = 26) or partially increased (ratio 1.25 to 4.0, n = 50) in the 500 nM data set were compared to the same peptides observed in the 50 nM data set. …”

Stress-strain curves under unconfined compression for samples with different cementation concentrations: (a) Concentration of 0.25 mol/L; (b) Concentration of 1 mol/L; (c) Concentr... by Xiaoyan Ding (291429)

Distribution of the unconfined compressive strength of specimens at different positions under different filling speeds: (a) Working condition M1; (b) Working condition M2; (c) Work... by Xiaoyan Ding (291429)

Inhibition of proliferation in CMV and HA-1 specific CTL clones decreases miR-625-3p upregulation. by Kriti Verma (4012211)

Aggressive blood pressure reduction is not associated with decreased perfusion in leukoaraiosis regions in acute intracerebral hemorrhage patients - Fig 1 by Mahesh Kate (4037570)

Cellular movements of AnSte7 and AnSte50::sGFP fusions and interactions of the AnSte11-Ste7, AnSte7-Fus3 complexes in the <i>steDΔ</i> mutant lacking AnSte50. by Özgür Bayram (150583)

“…Membrane localization of AnSte11-Ste7 kinases drastically decreases in <i>Anste50</i> [<i>steD</i>Δ] strain. …”

Deletion of <i>gtfP</i> in <i>S</i>. <i>sanguinis</i> decreases biofilm attachment and glucan synthesis. by Jinlin Liu (222960)

Kif2a accumulation at the base of <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia causes instability. by Emily Bowie (543704)

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells - Fig 3 by Tadeja Kuret (5059433)

Effects of GM-CSF on DMN-induced changes in liver morphology, texture, and weight. by Mrigendra Bir Karmacharya (13607415)

<i>In vivo</i> expression of EAC3I decreases s/mEPSC frequency in dorsal lateral striatum MSNs. by Jason R. Klug (132807)