First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Association between AIP and depression in total people by Siyi Deng (12887198)

Losartan is not neuroprotective in a crush model of axon injury. by Harry A. Quigley (695817)

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial by Michel Mandro (2637532)

“…The primary endpoint was defined as the probability of being seizure-free at month 4. A secondary endpoint was defined as >50% reduction in seizure frequency at month 4, compared to baseline. …”

Gas exchange model used to construct oxygen-haemoglobin dissociation curves (ODC) for the cohort. by Nikhil Mayor (13989363)

Depletion of <i>cyd-1</i> leads to decreased oocyte quality and increased apoptosis without affecting the DNA damage response (DDR). by Umanshi Rautela (20235283)

Strains carrying different <i>ELP3</i> mutant alleles show decreased telomeric gene silencing and increased HU sensitivity. by Changchun Chen (139128)

Image1_Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality.tif by Yi Zhang (9093)

“…Background<p>Infertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases. …”

Significantly decreased levels of CD4⁺CD25⁺ Treg cells in arthropathic Tax transgenic mice. by Takeo Ohsugi (225723)

“…(B) The majority of CD4⁺CD25⁺ T cells in non-transgenic mice expressed a high level of Foxp3 (81.2±1.4%), whereas half of CD4⁺CD25⁺ T cells in arthropathic Tax transgenic mice did not express Foxp3 (50.2±5.2%) (n = 6 per group), *** <i>P</i><0.001. …”

DataSheet1_Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression.PDF by Ying Meng (327793)

Decreased accumulation of inflammatory cells in SOCS1^−/−IFN-γ^−/− mice at the resolution phase of influenza infection. by Keer Sun (673151)

<i>PB-Cre4; SypELDTA</i> line 147 mice show decreased number of NE cells and prostate hypotrophy. by Chieh-Yang Cheng (405156)

Lack of p23 results in decreased epidermal thickness, delayed differentiation and increased rates of proliferation and apoptosis in E18.5 skin. by Marta Madon-Simon (527400)

“…Black bars in panels <b>a</b> and <b>d</b> indicate 50 μm.</p>…”

Effect of downregulation of <i>Pf</i>HtrA2 levels on mitochondrial oxidative stress and mitochondrial membrane potential. by Shweta Singh (409313)

Case 81, color-fundus and red-free fundus photography (A), peripapillary RNFL thickness measured by SD-OCT (B), and automated 30–2 visual field test (C). by Seong Jae Kim (4042847)

Case 6, color-fundus and red-free fundus photography (A), peripapillary RNFL thickness measured by SD-OCT (B), and automated 30–2 visual field test (C). by Seong Jae Kim (4042847)

30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany by Wido Rippe (7513133)

“…Unplanned readmission had more frequently a non-surgical treatment at readmission than a surgical treatment (OR = 3.92; CI = 2.24–6.84) and needed more frequently further diagnostics (OR = 2.34; CI = 1.34–4.11). …”

Case 161, color-fundus and red-free fundus photography (A), peripapillary RNFL thickness measured by SD-OCT (B), and automated 30–2 visual field test (C). by Seong Jae Kim (4042847)

Regional Volume Decreases in the Brain of <i>Pax6</i> Heterozygous Mutant Rats: MRI Deformation-Based Morphometry - Fig 5 by Kotaro Hiraoka (812730)