Discovery and <i>In Vitro</i> Characterization of SPL028: Deuterated <i>N</i>,<i>N</i>‑Dimethyltryptamine by Marie Layzell (16912785)

“…However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance. Here we describe the synthesis of deuterated analogues of DMT with the aim of prolonging the half-life and decreasing the clearance rate while maintaining similar pharmacological effects. …”

Data_Sheet_1_Study on Optimal Parameter and Target for Pulsed-Field Ablation of Atrial Fibrillation.DOCX by Xuying Ye (11459722)

“…Expressed Cx45 proteins were increased in H9C2 but decreased in A7r5 cells. Bidirectional PFA performed on Bama minipigs was able to effectively block electrical activity from the pulmonary vein to the atrium with week muscle contraction, not generating pulmonary vein stenosis. …”

Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model by Eun-Jung Kim (278998)

“…Indian hedgehog (Ihh), one of the hedgehog signaling molecules, is known to control both the hypertrophy of chondrocytes and bone replacement; these processes are particularly important in postnatal endochondral bone formation rather than in early chondrogenesis. In this study, we utilized the maternal transfer of 5E1 to E12.5 in mouse embryos, a process that leads to an attenuation of Ihh activity. …”

Effect of replacing Tifton Hay with Guandu Hay on intake, digestibility and ingestive behavior of dairy goats by Priscila Bernardo de Andrade (10414754)

“…The purpose was to evaluate the effect of replacement of Tifton 85 hay with Guandu hay on the intake, digestibility and ingestive behavior of dairy goats. Five Saanen goats with average milk production of 2.26 ± 0.10 kg d-1, around 123 ± 4 days of lactation were assigned to a 5 x 5 Latin square design. …”

Video_2_Study on Optimal Parameter and Target for Pulsed-Field Ablation of Atrial Fibrillation.MP4 by Xuying Ye (11459722)

“…Expressed Cx45 proteins were increased in H9C2 but decreased in A7r5 cells. Bidirectional PFA performed on Bama minipigs was able to effectively block electrical activity from the pulmonary vein to the atrium with week muscle contraction, not generating pulmonary vein stenosis. …”

GSL-1 treatment induces transcripts for GM3 and GD3 synthases and the anti-apoptotic protein Bcl-2. by Rafael L. Pereira (177990)

“…<p>BALB/c mice were injected at day 0 with 10 mg/kg of adriamycin (ADM) or treated concomitantly with ADM and 5 µg/mouse GSL-1 (ADM+GSL-1). (A) The ADM group showed decreased levels of ST8Sia1, the enzyme responsible for the generation of GD3 gangliosides, molecules that have been associated with podocyte physiology. …”

MYCN protein partners identified in NB cells. by Zhihui Liu (95891)

“…We demonstrate that MYCN cooperates with WDR5 and G9a to orchestrate global gene transcription. …”

Ventilation and indoor air quality in retail stores: A critical review (RP-1596) by Marwa Zaatari (537694)

“…Assessing the role of ventilation in mitigating this exposure is important to understand the energy implications of maintaining acceptable indoor air quality. In this work, we summarize results from 28 papers that report ventilation rates and/or pollutant concentrations in retail stores. …”

Supplementary Material for: Exploring Standardized Scales and Serum Biomarkers to Evaluate Changes in Pruritus due to Eczema after Japanese Kampo Treatment: A Prospective Case Seri... by Yoshino T. (6306305)

“…Background: We aimed to explore standardized scales and serum biomarkers for tracking changes in the symptoms and severity of pruritus due to eczema in patients treated with Kampo formulas. …”

Clinical experience with adjustable scleral lenses by César Lipener (5761328)

“…Regarding diagnosis, 72% of the patients had keratoconus; 12%, radial keratotomy; 5%, post-refractive surgery ectasia; 5%, dry eye; and 3%, high myopia. …”

Clinical experience with adjustable scleral lenses by César Lipener (5761328)

“…Regarding diagnosis, 72% of the patients had keratoconus; 12%, radial keratotomy; 5%, post-refractive surgery ectasia; 5%, dry eye; and 3%, high myopia. …”

Video_1_Study on Optimal Parameter and Target for Pulsed-Field Ablation of Atrial Fibrillation.MP4 by Xuying Ye (11459722)

“…Expressed Cx45 proteins were increased in H9C2 but decreased in A7r5 cells. Bidirectional PFA performed on Bama minipigs was able to effectively block electrical activity from the pulmonary vein to the atrium with week muscle contraction, not generating pulmonary vein stenosis. …”

Tet2 and Tet3 function upstream of the Notch and Wnt pathways during RGC differentiation and morphogenesis. by Pawat Seritrakul (4445662)

“…(I-L) Wnt signaling was upregulated by exposing wild-type embryos from 24hpf to 72hpf with 2μM BIO, a GSK3β inhibitor. (I,J) BIO-treated wild-type embryos showed reduced lamination, (K) a decreased percentage of <i>isl2b</i>:GFP⁺ RGCs per retina, and (L) decreased optic nerve diameter relative to DMSO-treated controls, (p = 0.00236 and p<0.0001). …”

Table_7_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

“…</p>Results<p>In the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10⁻⁵]. …”

Table_8_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

“…</p>Results<p>In the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10⁻⁵]. …”

Table_4_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

“…</p>Results<p>In the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10⁻⁵]. …”

Table_3_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

“…</p>Results<p>In the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10⁻⁵]. …”

DataSheet_1_High-resolution sampling in the eastern tropical North Atlantic reveals episodic Saharan dust deposition: implications for the marine carbon sink.docx by Blanda A. Matzenbacher (18873874)

“…Organic matter fluxes increased by 199.5% during high-flux dust events but decreased by 13.6% during anomalous grain-size events. …”

DataSheet_1_DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy.docx by Julie Dardare (14235308)

“…Migration and invasion properties of the cells were also determined using wound healing and transwell assays. Sensitivity to 5-fluorouracil (5-FU), oxaliplatin, irinotecan and gemcitabine were finally investigated by crystal violet assays.…”

Cooperation promotes pleiotropy. by Miguel dos Santos (3277746)

“…Because pleiotropic and nonpleiotropic are phenotypically similar, we expect them to be present in similar proportions relative to each other in the absence of mutations (i.e., 0.5). …”