Search alternatives:
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
b decrease » _ decrease (Expand Search), b1 decreased (Expand Search), ob decreased (Expand Search)
16 b » 16 _ (Expand Search), 1 b (Expand Search), 6 b (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
b decrease » _ decrease (Expand Search), b1 decreased (Expand Search), ob decreased (Expand Search)
16 b » 16 _ (Expand Search), 1 b (Expand Search), 6 b (Expand Search)
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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High resolution structures visible with the 25 nm zone plate objective.
Published 2022“…(<b>A</b>) The endoplasmic reticulum (ER) forms a silhouette (arrows) around the mitochondria and the ER lumen is visible with the 25 nm zone plate. …”
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FUD transiently decreased IOP in mice injected with Ad5-TGFβ2 viral vector.
Published 2020“…(B) IOPs were monitored for 5 more days (until Day 22) in a subset of mice from A. …”
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