Changes in the MR_820nm curves and parameters of Baijinpao and Kangnaixin under Al stress conditions. by Jing Zhang (23775)

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Absorption spectra of 12.5 mM sodium chlorite solutions with different concentrations of sulfuric acid. by Ayuta Kishimoto (16814662)

Changes in baseline T-cell activation markers through week 12 and week 24 according to the linear regression model. a. by Tosi M. Mwakyandile (16408705)

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Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

Changes in baseline T-cell exhaustion, monocyte activation and platelet activation markers through week 12 and week 24 according to the linear regression model. a. by Tosi M. Mwakyandile (16408705)

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MMP-2 production is decreased following ALK5 inhibition. by Rebecca A. Scott (488956)

Body weight, femoral length and <i>Notch3</i> transcripts of 8.5–9 week old male <i>Notch3</i>^{<i>em1Ecan</i>} mutant mice (gray bars) and littermate controls (white bars)... by Ernesto Canalis (516050)

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Leg and wing <i>IR52a</i>^<i>+</i> neurons form functional connections with neurons in the SEZ. by Zhe He (508742)

Reduction of thymic weight and size in rats administered cocaine. by Kana Unuma (283272)

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Increased levels of PPARγ as well as adiponectin in thymus from rats administered cocaine for 14 days. by Kana Unuma (283272)

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Reduction of thymic weight and size as well as ectopic development of adipocytes in thymus from rats administered cocaine for 14 days. by Kana Unuma (283272)

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The effects of GM-CSF on DMN-induced histopathological changes. by Mrigendra Bir Karmacharya (13607415)

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Effects of GM-CSF on the DMN-induced inhibition of PPAR-γ expression. by Mrigendra Bir Karmacharya (13607415)

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Effects of GM-CSF on DMN-induced TGF-β1 expression. by Mrigendra Bir Karmacharya (13607415)

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Western blot analysis of collagen type I, α-SMA, and TGF-β1 in liver. by Mrigendra Bir Karmacharya (13607415)

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Effects of GM-CSF on DMN-induced hepatotoxicity. by Mrigendra Bir Karmacharya (13607415)

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