Showing 801 - 820 results of 45,525 for search '(( 5 ((nm decrease) OR (mean decrease)) ) OR ( 50 ((nn decrease) OR (a decrease)) ))', query time: 0.95s Refine Results
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    Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α<sub>1A</sub>-Adrenoceptor Antagonists by Fei Zhao (183673)

    Published 2016
    “…In this study, two highly selective and potent α<sub>1A</sub>-AR antagonists, compounds (<i>R</i>)-<b>14r</b> (IC<sub>50</sub> = 2.7 nM, α<sub>1B</sub>/α<sub>1A</sub> = 640.1, α<sub>1D</sub>/α<sub>1A</sub> = 408.2) and (<i>R</i>)-<b>23l</b> (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 1506, α<sub>1D</sub>/α<sub>1A</sub> = 249.6), which exhibited similar activities and better selectivities in cell-based calcium assays as compared with the marketed drug silodosin (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 285.9, α<sub>1D</sub>/α<sub>1A</sub> = 14.4), were identified. …”
  17. 817

    Estradiol decreased vanillin-induced responses in the ORNs of p5 mice. by Ninthujah Kanageswaran (683924)

    Published 2016
    “…<p>(A) Representative responses to 100 μM vanillin from Olfr73 positive ORNs in tissue slices were obtained from patch-clamp recordings set to a voltage-clamp configuration (V<sub>h</sub> = -56 mV). The amplitude was decreased after 1-min preincubation with 1 nM estradiol. …”
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