Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

Anti-transforming growth factor beta (TGFβ) Ab decreased aristolochic acid (AA)-induced reticulum endoplasmic (ER) and mitochondrial (MT) stress protein expression in kidney tissue... by Agnieszka A. Pozdzik (3159222)

“…(<b>b-d</b>) Cell lysates from HUVEC and HK-2 incubated for 6 and 24 h with 50 ng/ml of AA and anti-TGFβ Ab or control Ab were immunobloted for ATPB, alpha smooth muscle actin (α-SMA), E-cadherin, ATPB, SDHA, p-PERK, vimentin, p-Smad2, p-Smad3, and tubulin proteins expression. …”

Predictive values of IC₅₀ in mM (FFAs) for vanadium compounds and <i>in vivo</i> observations IC₅₀ in mM (FFAs) and decreasing blood glucose level. by Elena V. Fedorova (603922)

Top 50 genes whose expression is most decreased in PN11 <i>Klf5</i>CN compared with the WT corneas. by Doreswamy Kenchegowda (135193)

Top 50 genes whose expression is most decreased in PN56 <i>Klf5</i>CN compared with the WT corneas. by Doreswamy Kenchegowda (135193)

Susceptibility of half knockout strains to CYP51 inhibitors (EC50, μM): compounds with decreased activity on HKO + CYP strains. by Laura-Isobel McCall (222498)

Changes in differential chlorophyll fluorescence curves modulated reflection at 820 nm. by Yousra El-Mejjaouy (15877635)

HoxA9-ER directly represses <i>Cebpa</i> gene expression in myeloid cells. by Lei Peng (260321)

KDM6A mRNA expression is decreased in PTFE mice. by Simon Lebek (9756148)

NTF effect on neuronal morphologies Effect of 50 ng/ml BDNF, 100 ng/ml CNTF and the combination of both NTFs (B/C) compared to negative control (NC) on neuronal morphology in terms... by Jana Schwieger (782065)

Changes in differential chlorophyll fluorescence curves modulated reflection at 820 nm. by Yousra El-Mejjaouy (15877635)

Effect of low doses of clothianidin on oriented responses of <i>A. ipsilon</i> males towards a 20-ng sex pheromone blend. by Kaouther K. Rabhi (675942)

“…<p>The percentage of responses of clothianidin-treated males divided by that of DMSO-treated males is represented. The 0.25-ng dose induced a significant decrease in oriented responses whereas the 10-ng dose induced a significant increase in sex pheromone oriented responses. …”

Nearly 1000 Protein Identifications from 50 ng of <i>Xenopus laevis</i> Zygote Homogenate Using Online Sample Preparation on a Strong Cation Exchange Monolith Based Microreactor Co... by Zhenbin Zhang (1444888)

“…This combination of basic elution and acidic background electrolytes results in both sample stacking and formation of a dynamic pH junction. 369 protein groups and 1274 peptides were identified from 50 ng of <i>Xenopus laevis</i> zygote homogenate, which is comparable with an offline sample preparation method, but the time required for sample preparation was decreased from over 24 h to less than 40 min. …”

Effect of specific inhibitors on CYP-mediated CK (50 μM) metabolism in HLMs. by Jian Xiao (253329)

Five compounds significantly decrease MAPK1 phosphorylation in K562 cells. by Pamela Y. Ting (713174)

Inflammatory conditions decrease CD36 expression and CD36-mediated <i>Pf</i>PEs phagocytosis through downregulation of PPARγ. by David Olagnier (205583)

Exposure of HOB to chemotherapeutic agents or rTGF-β1 decreased the expression of CXCL-12 and diminished support of pro-B cell chemotaxis. by Stephanie L. Rellick (182765)

Assays of TUNEL revealed a decreased number of apoptotic cell after oroxylin A treatment. by Shu-Fang Lin (4167091)

KYNA and zaprinast decrease the [Ca²⁺]i plateau phase following an IP3-mediated stimulus in mouse cortical astrocytes. by Rolando Berlinguer-Palmini (491113)

“…<b>E</b>) Time course of MRS-1845, D-APV (50 µM) and MLA (100 nM) effects on fluo-3 fluorescence in a single astrocyte in cultures. …”