Immucillins Impair <i>Leishmania (L</i>.<i>) infantum chagasi</i> and <i>Leishmania (L</i>.<i>) amazonensis</i> Multiplication <i>In Vitro</i> by Elisangela Oliveira Freitas (729807)

“…<i>) amazonensis</i> promastigotes were determined using 0.05–500 μM and, when needed, 0.01–50 nM of each drug. The inhibition on multiplication of <i>L</i>. …”

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice by Miroslava Anderova (155561)

“…Similarly, evaluation of relative α changes showed a significantly smaller decrease in α-syntrophin knockout mice only during severe pathological conditions, but not during mild stimuli. …”

Data_Sheet_1_Long-Term Prognosis of Cognitive Function in Patients With Idiopathic Normal Pressure Hydrocephalus After Shunt Surgery.xlsx by Akihiro Kambara (10006775)

“…The patients were classified in to the cognitive decline group [11 (23%) patients; a decrease in the MMSE score by ≥ 2 points 2 years after surgery] and the maintenance/improvement group [37 (77%) patients]. …”

Table1_Baseline Plasma Metabotype Correlates With Direct-Acting Antiviral Therapy Nonresponse for HCV in HIV–HCV Coinfected Patients.XLSX by Gaurav Tripathi (3163251)

“…Post therapy, 62 plasma metabolites (12 upregulated and 50 downregulated, FC±1.5, p < 0.05) differentiated nonresponders from responders and highlighted a significant increase in the steroid and histidine metabolism and significant decrease in tryptophan metabolism and ascorbate and pyruvate metabolism in the nonresponders. …”

Partial silencing of GFP requires both EhRNaseIII and ScaAgo1. by Justine M. Pompey (268775)

“…FACS histogram of GFP fluorescence in the indicated strains show a decrease in GFP fluorescence in strain expressing EhRNaseIII using the strong GFP silencing hairpin but only in the strain expressing ScaAgo1. …”

datasheet1_In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis.docx by Dahara Keyse Carvalho Silva (9774635)

“…In vitro incubation with LASSBio-1386 reduced the percentage of Leishmania-infected macrophages and the number of intracellular parasites (EC₅₀ = 9.42 ± 0.64 µM). Also, in vivo treatment of BALB/c mice infected with L. amazonensis resulted in a decrease of lesion size, parasitic load and caused histopathological alterations, when compared to vehicle-treated control. …”

MK-2206 induced cytotoxicity, inhibited proliferation and was able to overcome the protective effects of the tumor microenvironment. by Vijay Ramakrishnan (117159)

“…<p>When we cultured MM cell lines with indicated concentrations of MK-2206 for 48 hrs we observed dose dependent decrease in <b>A)</b> viability as observed by MTT assays and <b>B)</b> tritiated thymidine uptake indicative of inhibition of proliferation albeit with differences in the sensitivity of cell lines to MK-2206. …”

Fast two-photon imaging of calcium rise times in spines and dendrites. by L. Niels Cornelisse (67656)

“…Right panel: fluorescence decreases after each AP in 50 Hz train. Dotted line indicates the average fluorescence increase induced by the last 3 APs in the train. …”

Datasheet1_Hyperbaric effects on heart rate in professional SCUBA divers in thermal water.pdf by Luigi Fattorini (19758798)

Retinal histology examination after 10 weeks of ocular hypertension. by Nicolás Belforte (328093)

“…Scale bar: Upper panel  =  50 µm; Middle panel  =  50 µm. Data are the mean ± SEM (n = 5 animals per group). * p<0.05, ** p<0.01 vehicle injected eyes without ischemia pulses (sham), a: p<0.05, b: p<0.01 versus CS-injected eyes without ischemia pulses (sham), by Tukey's test. …”

Effects of the ambient temperature on the behavioral responses. by Ivanne Pincedé (270921)

Non-Temperature Induced Effects of Magnetized Iron Oxide Nanoparticles in Alternating Magnetic Field in Cancer Cells by Sudath Hapuarachchige (2203699)

Allelopathic Effects of Different Plant Water Extracts on Yield and Weeds of Wheat by M. NAEEM (5862101)

“…In this study, mixtures of allelopathic water extracts of sorghum + sunflower and sorghum + sunflower + mulberry were sprayed each at 12, 15, 18 and 21 L ha-1 at 40 and 55 days after sowing in wheat to control wild oats (Avena fatua), little seed canary grass (Phalaris minor), lamb’s quarters (Chenopodium album) and swine cress (Coronopus didymus). A synthetic herbicide Affinity 50 WP (Carfentrazone-ethyl 0.75% + Isoproturon 50% applied at 1000 g a.i., ha-1) and a weedy check were kept as a control treatment. …”

Self-Powered Biosensing System with Multivariate Signal Amplification for Real-Time Amplified Detection of PDGF-BB by Futing Wang (14851840)

The <i>baldrian</i> mutation interferes with embryonic cardiomyocyte proliferation in zebrafish. by Anja Bühler (2556937)

STUDY OF THE CHROMIUM(VI) REMOVAL FROM AQUEOUS SYSTEMS BY COBALT NANOPARTICLES by Patricia G. Leles (7032722)

“…The obtained nanomaterials presented magnetic properties and were characterized by the techniques of Transmission Electron Microscopy and X-ray diffraction. The NPs-Co, with a diameter of less than 50 nm, had a composition based on metallic cobalt and cobalt oxide. …”

Bulk Nanobubbles Fabricated by Repeated Compression of Microbubbles by Juan Jin (603043)

“…The results show that NBs with a mean diameter of 240 ± 9 nm and a polydispersity index of 0.25 were successfully prepared. …”

Specificities mediating neutralization breadth and potency in the top 42 Protocol C neutralizers. by Elise Landais (845745)

“…Absent (-), very weak (+/-), weak (+), moderate (++), strong (+++), phenotype was attributed based on i) the median fold or average percent decrease in ID50 and ii) the fraction of viruses which neutralization ID50 was decreased <2 fold, <10 <50 fold or <20%, <40%, <60%, <80%. …”

Qualitative comparison of the results of the ISS T-002 and the ISS OBS T-002 up to 48 weeks: central and effector memory T cell phenotype and cellular immune responses. by Barbara Ensoli (120173)