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nm decrease » _ decrease (Expand Search), gy decreased (Expand Search), b1 decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
nm decrease » _ decrease (Expand Search), gy decreased (Expand Search), b1 decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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GluN2A(D731N) decreases channel open probability.
Published 2017“…The di-heteromeric mutant (2A-D731N) and tri-heteromeric receptors with two-copies of the mutant subunit (D731N/D731N) showed a prolonged inhibition rate, reflecting a decreased channel open probability. …”
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Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α<sub>1A</sub>-Adrenoceptor Antagonists
Published 2016“…In this study, two highly selective and potent α<sub>1A</sub>-AR antagonists, compounds (<i>R</i>)-<b>14r</b> (IC<sub>50</sub> = 2.7 nM, α<sub>1B</sub>/α<sub>1A</sub> = 640.1, α<sub>1D</sub>/α<sub>1A</sub> = 408.2) and (<i>R</i>)-<b>23l</b> (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 1506, α<sub>1D</sub>/α<sub>1A</sub> = 249.6), which exhibited similar activities and better selectivities in cell-based calcium assays as compared with the marketed drug silodosin (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 285.9, α<sub>1D</sub>/α<sub>1A</sub> = 14.4), were identified. …”
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A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <i>In Vivo</i> and Regulates Urethral Tension
Published 2014“…To date, several autotaxin/ENPP2 inhibitors have been reported; however, none were able to completely and continuously inhibit autotaxin/ENPP2 <i>in vivo</i>. In this study, we report the discovery of a highly potent autotaxin/ENPP2 inhibitor, ONO-8430506, which decreased plasma lysophosphatidic acid formation.…”
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429
Over-expression of DN VPS4 in HEK293T cells leads to increased extracellular α-synuclein and parallel decrease in lysosome.
Published 2013“…Each fraction was verified by the presence of a specific marker protein: LAMP-1 (late endosome and lysosome), Rab5 (early endosome), Rab11 (recycling endosome), Hsp90 (cytosol), and BSA (culture medium). …”
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Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ul...
Published 2015“…</p><p>Results</p><p>BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. …”
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Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
Published 2013“…In two human Ph+ALL cell lines, inhibition of ErbB kinase activity with canertinib resulted in a dose-dependent decrease in the phosphorylation of an ErbB kinase signaling target p70S6-kinase T389 (by 60% in Z119 and 39% in Z181 cells at 3 µM). …”
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