Restoring CDK4 rescues RelA induced proliferation arrest. by Bose S. Kochupurakkal (430472)

“…Following incubation with Dox, the cells were treated with PD0332991 (CDK4/6 inhibitor, 200nM) or CVT-313 (CDK2 inhibitor, 5μM) as indicated for 12 hours. …”

Histological sections and Mankin score of rabbit cartilages also showed OA change at 2 weeks. by Kohei Nishitani (526108)

“…<p>A) OA change such as fibrillation of the surface and decrease of safranin/O stainingwas detected from 2 weeks and deteriorated overtime. …”

ANALYSIS OF MASTER SWIMMERS’ SPORT PERFORMANCE FOR DIFFERENT FREESTYLE DISTANCES by André Geraldo Brauer Júnior (5311607)

“…<div><p>ABSTRACT The aim of this study was to analyze the decline rate of master swimmers’ world records compared to absolute world records, and sport performance decrease for both genders and different age groups (25 to 99 years old) in 50, 400 and 1500 meters freestyle swimming. …”

Data Supplement from Epigenetic Targeting of Ovarian Cancer Stem Cells by Yinu Wang (14844702)

“…Time-course cell cycle analysis of platinum sensitive A2780 ovarian cancer cells and platinum resistant A2780_CR5 and SKOV3 OC cells after 72 hour daily treatment with low dose SGI-110 (100nM). …”

Immucillins Impair <i>Leishmania (L</i>.<i>) infantum chagasi</i> and <i>Leishmania (L</i>.<i>) amazonensis</i> Multiplication <i>In Vitro</i> by Elisangela Oliveira Freitas (729807)

“…<i>) amazonensis</i> promastigotes were determined using 0.05–500 μM and, when needed, 0.01–50 nM of each drug. The inhibition on multiplication of <i>L</i>. …”

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

Effect of EE housing on retinal synaptophysin- and Müller cell and astrocyte GFAP-immunoreactivity. by Damián Dorfman (293002)

“…Scale bar: 50 µm for panel A, B and C, and scale bar: 100 µm for panel D.…”

Chloroquine (CQ) treatment blocks autophagosome–lysosome fusion and induces myopathy in the larva. by Jonathan Zirin (483506)

Measurement of mitochondrial function in nasal fibroblasts with and without TGF-β1 or with and without PX-478 To investigate whether mitochondrial function are elevated by TGF-β1,... by Min-Sik Jo (14636809)

“…<p>Oxygen consumption rate (OCR) was significantly increased at 5 ng/ml TGF-β1 (S1A Fig). To determined whether PX-478 decrease mitochondrial function, PX-478 (20 nM) was pretreated for 1 hour, followed by TGF-β1 48 hours. …”

Effect of γ-lactones and γ-lactams compounds on Streptococcus mutans biofilms by Mariane Beatriz Sordi (4695625)

“…Afterwards, we measured the planktonic growth by optical density at 630 nm and therefore assessed the biofilm density by the crystal violet staining method. …”

DataSheet1_The wet scavenging of air pollutants through artificial precipitation enhancement: A case study in the Yangtze River Delta.docx by Yixuan Wu (736336)

“…After the precipitation, the number concentration of aerosols with a diameter lower than 300 nm reduces significantly, the mass concentration of particulate matter with an aerodynamic diameter less than 2.5 μm decreases by about 39%, and the mass concentrations of nitrogen dioxide, sulfur dioxide, and carbon monoxide also decrease in different degrees. …”

Flagellar size regulation. by Deb Sankar Banerjee (12890259)

“…Parameters: tubulin concentration = 5 <i>μ</i>M, <i>α</i> = 1, <i>β</i> = 0, tubulin size = 10 nm, <i>k</i>⁺ = 120 <i>μ</i>m³ min⁻¹, <i>k</i>⁻ = 100 min⁻¹, <i>t</i>₀ = 1000 min, production rate of new subunits <i>r</i>_<i>p</i> = 0.0016 min⁻¹.…”

TgPH1 retains membrane association in genetically-impaired PIKfyve cells. by Krishna Chintaluri (5340959)

“…Live-cell imaging of Cos-7 cells expressing NES-iRFP-TgPH1 treated with vehicle alone or with 100 nM apilimod or 1 μM YM201636 for 1 h; the drugs cause a characteristic appearance of swollen vacuoles, some of which labelled with the TgPH1 probes. …”

File S1 - <i>Lactobacillus gasseri</i> SF1183 Affects Intestinal Epithelial Cell Survival and Growth by Blanda Di Luccia (407048)

“…Two main peaks were observed at 220 nm. Figure S2, chromatographic fractions from the experiment of Fig. …”

Mammalian enamel maturation: Crystallographic changes prior to tooth eruption by Anna Kallistová (3746470)

“…Correspondingly, at the distal part of the tooth the timing of maturation processes is delayed by 3-5 month compared to the mesial part of the tooth. …”

Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib by A. L. Furfaro (2587792)

“…Using the highly chemoresistant neuroblastoma cells HTLA-230, here we show that the strong reduction in proteasome activity, obtained by using low concentration of bortezomib (BTZ, 2.5 nM), fails in reducing cell viability. BTZ treatment favours the binding of Nrf2 to the ARE sequences in the promoter regions of target genes such as heme oxygenase 1 (HO-1), the modulatory subunit of γ-glutamylcysteine ligase (GCLM) and the transporter for cysteine (x-CT), enabling their transcription. …”

Aromatic Ring-Fused BODIPY-Based Conjugated Polymers Exhibiting Narrow Near-Infrared Emission Bands by Atsushi Nagai (36896)

“…Three conjugated copolymers, consisted of alternating <i>p</i>-phenylene-ethynylene and boron di(iso)indomethene units in the backbone, were synthesized via palladium-catalyzed Sonogashira coupling reaction of 1,4-diethynyl-2,5-dihexadecyloxybenzene and three diiodophenyl-fused BODIPY monomers. …”

TRPS1 directly represses regulatory element activity. by Thomas G. Scott (4092892)

“…<p>A: MA plot of ATAC-seq peaks, with fold change values representing accessibility in the 30 minute dTAG-13 and dTAG^V-1 at 50nM each (dTAG) treatment condition relative to the DMSO condition. …”

Thermal denaturation and structural features of the R-BSX mutants. by Amit Bharadwaj (86208)

“…<p>(A) CD spectra of thermal denaturation of ΔV1, V1L, V1D, V1F, V1A and R-BSX monitored at 222 nm with a temperature slope of 1°C/min. …”

Table_1_The Capsid Protein VP1 of Coxsackievirus B Induces Cell Cycle Arrest by Up-Regulating Heat Shock Protein 70.xlsx by Yao Wang (102387)