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Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation.
Published 2024“…Large circles show mean of cells from 5 fields of view from a single animal. (D) Immunoblot showing p53 protein expression is decreased in colon tissue from 5-month old HA-MAD1 mice after 1 week of 6 mg/kg dox feed as compared to control. …”
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TUDCA decreases ER stress in HOX neonatal rat lungs.
Published 2022“…(<b>C</b>) In IHC stain, P-IRE1α levels are decreased (40.8±3.5 A.U. <i>vs</i> 53.1±5.0 A.U., p<0.001, n = 6, 3 for each sex) in chronic hyperoxia exposed neonatal rat lungs by TUDCA. …”
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RNA analysis reveals a ~6-fold reduced coverage of exon 26 in the murine <i>Tg</i> gene.
Published 2025“…<p>(A) <i>Tg</i> transcriptional coverage in B6NCrl (CRL) and B6NTac (Taconic) thyroid samples determined by RNAseq. …”
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90
Decreased clonal burden in relapses over time.
Published 2022“…<p>(A) Among 127 relapses in returning Indonesian soldiers, the number of <i>pvmsp1</i> clones detected at relapse decreased over time, as measured by days since enrollment one month after arriving to Java (slope = -0.003, p = 0.01). …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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