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Most miRNAs in Ago1 RISC are stable with age whereas transposon siRNAs in Ago2 RISC decrease with age.
Published 2022“…(B) miRNAs in Ago1 RISC from old and young females are plotted as percentage of mapped reads. miR-34-5p and miR-14-3p do not change by 2-fold. miR-318-3p and miR-994-5p decrease by 2-fold with age. …”
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Expression of nuclear receptor (NR) genes using dual recombinase-mediated cassette exchange.
Published 2024Subjects: -
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Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T...
Published 2022“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC<sub>(tofacitinib, 0–∞)</sub> and a 9.61-fold increase of colonic AUC<sub>(tofacitinib, 0–12h)</sub>, compared with tofacitinib at a molar equivalent oral dose. …”
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Image_2_IL-1β enhances cell viability and decreases 5-FU sensitivity in novel colon cancer cell lines derived from African American patients.tif
Published 2022“…When compared to Caucasian American (CA) patients, AAs also have reduced response to the first line standard of care chemotherapeutic agent 5-Fluorouracil (5-FU). Previously, we observed differential gene expression between the two populations, suggesting that colon tumors from AA patients display a decreased antitumor immune response and an increased expression of genes encoding proteins involved in inflammatory processes, such as Interleukin-1β (IL-1β). …”
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