Search alternatives:
sizes decrease » size increase (Expand Search), scores decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
c decrease » c decreased (Expand Search), _ decrease (Expand Search), rc decreased (Expand Search)
5 sizes » _ sizes (Expand Search)
5 c » 25 c (Expand Search)
sizes decrease » size increase (Expand Search), scores decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
c decrease » c decreased (Expand Search), _ decrease (Expand Search), rc decreased (Expand Search)
5 sizes » _ sizes (Expand Search)
5 c » 25 c (Expand Search)
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Primary small molecule screen to identify attenuators of CSE-induced decrease in size and increase in MUC5AC.
Published 2023“…Hit compounds at 1 and 10μM concentrations that <b>B)</b> increased spheroid size (swell) or <b>C)</b> decreased MUC5AC staining in the lumen relative to DMSO and CSE 3%-treated bronchospheres. …”
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Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
Published 2023“…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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